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An assessment of lifestyle modification versus medical treatment with clomiphene citrate, metformin, and clomiphene citrate-metformin in patients with polycystic ovary syndrome.
Fertil Steril. 2010 Jun; 94(1):216-20.FS

Abstract

OBJECTIVE

To compare the effect of clomiphene citrate, metformin, and lifestyle modification on treatment of patients with polycystic ovary syndrome (PCOS).

DESIGN

Prospective randomized double-blind study.

SETTING

University-based infertility clinic and research center.

PATIENT(S)

Three hundred forty-three overweight infertile women with PCOS.

INTERVENTION(S)

The participating women were assigned to four groups: clomiphene (n = 90), metformin (n = 90), clomiphene + metformin (n = 88), and lifestyle modification (n = 75). The patients in each group received standardized dietary and exercise advice from a dietitian.

MAIN OUTCOME MEASURE(S)

The primary outcome variables were change in menstrual cycle, waist circumference measurements, endocrine parameters, and lipid profile. The main secondary outcome variable was clinical pregnancy rate.

RESULT(S)

The clinical pregnancy rate was 12.2% in clomiphene group, 14.4% in metformin group, 14.8% in clomiphene + metformin group, and 20% in lifestyle modification group. Lifestyle modification group achieved a significant reduction in waist circumference, total androgen, and lipid profile.

CONCLUSION(S)

Lifestyle modification improves the lipid profile in PCOS patients. Therefore, lifestyle modification may be used as the first line of ovulation induction in PCOS patients.

Authors+Show Affiliations

Research and Clinical Center for Infertility, Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran. nikanresearch@gmail.comNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19463994

Citation

Karimzadeh, Mohammad Ali, and Mojgan Javedani. "An Assessment of Lifestyle Modification Versus Medical Treatment With Clomiphene Citrate, Metformin, and Clomiphene Citrate-metformin in Patients With Polycystic Ovary Syndrome." Fertility and Sterility, vol. 94, no. 1, 2010, pp. 216-20.
Karimzadeh MA, Javedani M. An assessment of lifestyle modification versus medical treatment with clomiphene citrate, metformin, and clomiphene citrate-metformin in patients with polycystic ovary syndrome. Fertil Steril. 2010;94(1):216-20.
Karimzadeh, M. A., & Javedani, M. (2010). An assessment of lifestyle modification versus medical treatment with clomiphene citrate, metformin, and clomiphene citrate-metformin in patients with polycystic ovary syndrome. Fertility and Sterility, 94(1), 216-20. https://doi.org/10.1016/j.fertnstert.2009.02.078
Karimzadeh MA, Javedani M. An Assessment of Lifestyle Modification Versus Medical Treatment With Clomiphene Citrate, Metformin, and Clomiphene Citrate-metformin in Patients With Polycystic Ovary Syndrome. Fertil Steril. 2010;94(1):216-20. PubMed PMID: 19463994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An assessment of lifestyle modification versus medical treatment with clomiphene citrate, metformin, and clomiphene citrate-metformin in patients with polycystic ovary syndrome. AU - Karimzadeh,Mohammad Ali, AU - Javedani,Mojgan, Y1 - 2009/05/21/ PY - 2008/10/22/received PY - 2009/02/12/revised PY - 2009/02/25/accepted PY - 2009/5/26/entrez PY - 2009/5/26/pubmed PY - 2010/6/18/medline SP - 216 EP - 20 JF - Fertility and sterility JO - Fertil Steril VL - 94 IS - 1 N2 - OBJECTIVE: To compare the effect of clomiphene citrate, metformin, and lifestyle modification on treatment of patients with polycystic ovary syndrome (PCOS). DESIGN: Prospective randomized double-blind study. SETTING: University-based infertility clinic and research center. PATIENT(S): Three hundred forty-three overweight infertile women with PCOS. INTERVENTION(S): The participating women were assigned to four groups: clomiphene (n = 90), metformin (n = 90), clomiphene + metformin (n = 88), and lifestyle modification (n = 75). The patients in each group received standardized dietary and exercise advice from a dietitian. MAIN OUTCOME MEASURE(S): The primary outcome variables were change in menstrual cycle, waist circumference measurements, endocrine parameters, and lipid profile. The main secondary outcome variable was clinical pregnancy rate. RESULT(S): The clinical pregnancy rate was 12.2% in clomiphene group, 14.4% in metformin group, 14.8% in clomiphene + metformin group, and 20% in lifestyle modification group. Lifestyle modification group achieved a significant reduction in waist circumference, total androgen, and lipid profile. CONCLUSION(S): Lifestyle modification improves the lipid profile in PCOS patients. Therefore, lifestyle modification may be used as the first line of ovulation induction in PCOS patients. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/19463994/An_assessment_of_lifestyle_modification_versus_medical_treatment_with_clomiphene_citrate_metformin_and_clomiphene_citrate_metformin_in_patients_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(09)00505-6 DB - PRIME DP - Unbound Medicine ER -