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Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study.
Ophthalmology. 2009 Jul; 116(7):1257-63, 1263.e1-2.O

Abstract

OBJECTIVE

To evaluate and compare the retinal nerve fiber layer (RNFL) measurement variability, diagnostic sensitivity and specificity for glaucoma detection, and strength of the structure-function association obtained with a spectral-domain optical coherence tomography (OCT) device (Cirrus HD-OCT; Carl Zeiss Meditec, Inc., Dublin, CA) and a time-domain OCT device (Stratus OCT; Carl Zeiss Meditec, Inc.).

DESIGN

Prospective, cross-sectional study.

PARTICIPANTS

Ninety-seven normal subjects and 83 glaucoma patients.

METHODS

One eye from each subject was imaged with Cirrus HD-OCT and Stratus OCT. Sixteen and 31 normal eyes were selected randomly to evaluate intravisit repeatability and intervisit reproducibility, respectively. The agreement of RNFL measurements was evaluated with Bland-Altman plots. The diagnostic sensitivity and specificity was examined with the area under the receiver operating characteristic curve (AUC). The association between average RNFL thickness and visual field sensitivity was evaluated with a second-order regression model.

MAIN OUTCOME MEASURES

Retinal nerve fiber layer measurement variability, AUC, and coefficient of determination (R(2)).

RESULTS

The intravisit repeatability of Cirrus HD-OCT ranged between 5.12 and 15.02 mum, and the intervisit reproducibility ranged between 4.31 and 22.01 mum. The intervisit variabilities of sectoral and average RNFL thicknesses were lower in Cirrus HD-OCT compared with Stratus OCT with significant differences at 1, 3, 4, and 8 to 11 o'clock (P< or =0.021). There were proportional biases of RNFL measurements between the 2 OCT devices. The difference of RNFL thicknesses increased with the means. The average (AUC, 0.962 for Cirrus HD-OCT and 0.956 Stratus OCT), superior (AUC, 0.963 and 0.950, respectively), and inferior (AUC, 0.949 and 0.931, respectively) RNFL thicknesses demonstrated the greatest AUCs in both OCT devices with no significant difference detected between the respective measurements (P> or =0.120). The strength of the structure-function association was comparable between Cirrus HD-OCT (R(2) = 0.580) and Stratus OCT devices (R(2) = 0.623; P = 0.918).

CONCLUSIONS

Although the diagnostic performance and the strength of the structure-function association were comparable between Cirrus HD-OCT and Stratus OCT RNFL measurements, Cirrus HD-OCT demonstrated lower measurement variability compared with Stratus OCT with significant differences at 1, 3, 4, and 8 to 11 o'clock. The poor agreement was likely related to the different inherent characteristics of the 2 OCT systems.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, People's Republic of China. tlims00@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19464061

Citation

Leung, Christopher Kai-Shun, et al. "Retinal Nerve Fiber Layer Imaging With Spectral-domain Optical Coherence Tomography: a Variability and Diagnostic Performance Study." Ophthalmology, vol. 116, no. 7, 2009, pp. 1257-63, 1263.e1-2.
Leung CK, Cheung CY, Weinreb RN, et al. Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study. Ophthalmology. 2009;116(7):1257-63, 1263.e1-2.
Leung, C. K., Cheung, C. Y., Weinreb, R. N., Qiu, Q., Liu, S., Li, H., Xu, G., Fan, N., Huang, L., Pang, C. P., & Lam, D. S. (2009). Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study. Ophthalmology, 116(7), 1257-63, e1-2. https://doi.org/10.1016/j.ophtha.2009.04.013
Leung CK, et al. Retinal Nerve Fiber Layer Imaging With Spectral-domain Optical Coherence Tomography: a Variability and Diagnostic Performance Study. Ophthalmology. 2009;116(7):1257-63, 1263.e1-2. PubMed PMID: 19464061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study. AU - Leung,Christopher Kai-Shun, AU - Cheung,Carol Yim-Lui, AU - Weinreb,Robert N, AU - Qiu,Quanliang, AU - Liu,Shu, AU - Li,Haitao, AU - Xu,Guihua, AU - Fan,Ning, AU - Huang,Lina, AU - Pang,Chi-Pui, AU - Lam,Dennis Shun Chiu, Y1 - 2009/05/22/ PY - 2008/10/03/received PY - 2009/04/03/revised PY - 2009/04/03/accepted PY - 2009/5/26/entrez PY - 2009/5/26/pubmed PY - 2009/7/16/medline SP - 1257-63, 1263.e1-2 JF - Ophthalmology JO - Ophthalmology VL - 116 IS - 7 N2 - OBJECTIVE: To evaluate and compare the retinal nerve fiber layer (RNFL) measurement variability, diagnostic sensitivity and specificity for glaucoma detection, and strength of the structure-function association obtained with a spectral-domain optical coherence tomography (OCT) device (Cirrus HD-OCT; Carl Zeiss Meditec, Inc., Dublin, CA) and a time-domain OCT device (Stratus OCT; Carl Zeiss Meditec, Inc.). DESIGN: Prospective, cross-sectional study. PARTICIPANTS: Ninety-seven normal subjects and 83 glaucoma patients. METHODS: One eye from each subject was imaged with Cirrus HD-OCT and Stratus OCT. Sixteen and 31 normal eyes were selected randomly to evaluate intravisit repeatability and intervisit reproducibility, respectively. The agreement of RNFL measurements was evaluated with Bland-Altman plots. The diagnostic sensitivity and specificity was examined with the area under the receiver operating characteristic curve (AUC). The association between average RNFL thickness and visual field sensitivity was evaluated with a second-order regression model. MAIN OUTCOME MEASURES: Retinal nerve fiber layer measurement variability, AUC, and coefficient of determination (R(2)). RESULTS: The intravisit repeatability of Cirrus HD-OCT ranged between 5.12 and 15.02 mum, and the intervisit reproducibility ranged between 4.31 and 22.01 mum. The intervisit variabilities of sectoral and average RNFL thicknesses were lower in Cirrus HD-OCT compared with Stratus OCT with significant differences at 1, 3, 4, and 8 to 11 o'clock (P< or =0.021). There were proportional biases of RNFL measurements between the 2 OCT devices. The difference of RNFL thicknesses increased with the means. The average (AUC, 0.962 for Cirrus HD-OCT and 0.956 Stratus OCT), superior (AUC, 0.963 and 0.950, respectively), and inferior (AUC, 0.949 and 0.931, respectively) RNFL thicknesses demonstrated the greatest AUCs in both OCT devices with no significant difference detected between the respective measurements (P> or =0.120). The strength of the structure-function association was comparable between Cirrus HD-OCT (R(2) = 0.580) and Stratus OCT devices (R(2) = 0.623; P = 0.918). CONCLUSIONS: Although the diagnostic performance and the strength of the structure-function association were comparable between Cirrus HD-OCT and Stratus OCT RNFL measurements, Cirrus HD-OCT demonstrated lower measurement variability compared with Stratus OCT with significant differences at 1, 3, 4, and 8 to 11 o'clock. The poor agreement was likely related to the different inherent characteristics of the 2 OCT systems. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/19464061/Retinal_nerve_fiber_layer_imaging_with_spectral_domain_optical_coherence_tomography:_a_variability_and_diagnostic_performance_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(09)00365-0 DB - PRIME DP - Unbound Medicine ER -