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Long-term meat intake and risk of breast cancer by oestrogen and progesterone receptor status in a cohort of Swedish women.
Eur J Cancer. 2009 Nov; 45(17):3042-6.EJ

Abstract

Red meat intake has been postulated to increase the risk of breast cancer but epidemiologic studies have yielded inconsistent results. Data on meat intake in relation to hormone receptor-defined breast cancer are sparse. We examined the association of meat intake with incidence of breast cancer defined by oestrogen receptor (ER) and progesterone receptor (PR) status in the Swedish Mammography Cohort, a population-based cohort of 61,433 women. Dietary intake was assessed at baseline in 1987-1990 and again in 1997. Cox proportional hazards models were used to estimate relative risks for the association between long-term meat intake and breast cancer risk. During a mean follow-up of 17.4 years, 2952 incident cases of invasive breast cancer were ascertained. We found no association of total red meat, fresh red meat or processed meat intake with breast cancer risk. The multivariate relative risks (95% confidence interval) for the highest quintile of total red meat intake (98 g/d) compared with the lowest quintile (<46 g/d) were 0.98 (0.86-1.12) for overall breast cancer, 1.10 (0.90-1.34) for ER+/PR+ tumours, 0.86 (0.60-1.23) for ER+/PR- tumours and 1.12 (0.70-1.79) for ER-/PR- tumours. Intake of pan-fried meat was positively associated with a risk of ER+/PR- tumours; the multivariate relative risk for the highest compared with the lowest quartile of intake was 1.45 (95% confidence interval 1.03-2.03; P(trend)=0.03). These results do not support an association between red meat intake and overall breast cancer risk but suggest that fried meat intake may increase the risk of ER+/PR- breast cancer.

Authors+Show Affiliations

Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, PO Box 210, SE-171 77 Stockholm, Sweden. susanna.larsson@ki.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19464165

Citation

Larsson, Susanna C., et al. "Long-term Meat Intake and Risk of Breast Cancer By Oestrogen and Progesterone Receptor Status in a Cohort of Swedish Women." European Journal of Cancer (Oxford, England : 1990), vol. 45, no. 17, 2009, pp. 3042-6.
Larsson SC, Bergkvist L, Wolk A. Long-term meat intake and risk of breast cancer by oestrogen and progesterone receptor status in a cohort of Swedish women. Eur J Cancer. 2009;45(17):3042-6.
Larsson, S. C., Bergkvist, L., & Wolk, A. (2009). Long-term meat intake and risk of breast cancer by oestrogen and progesterone receptor status in a cohort of Swedish women. European Journal of Cancer (Oxford, England : 1990), 45(17), 3042-6. https://doi.org/10.1016/j.ejca.2009.04.035
Larsson SC, Bergkvist L, Wolk A. Long-term Meat Intake and Risk of Breast Cancer By Oestrogen and Progesterone Receptor Status in a Cohort of Swedish Women. Eur J Cancer. 2009;45(17):3042-6. PubMed PMID: 19464165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term meat intake and risk of breast cancer by oestrogen and progesterone receptor status in a cohort of Swedish women. AU - Larsson,Susanna C, AU - Bergkvist,Leif, AU - Wolk,Alicja, Y1 - 2009/05/20/ PY - 2009/03/30/received PY - 2009/04/27/revised PY - 2009/04/28/accepted PY - 2009/5/26/entrez PY - 2009/5/26/pubmed PY - 2010/1/28/medline SP - 3042 EP - 6 JF - European journal of cancer (Oxford, England : 1990) JO - Eur. J. Cancer VL - 45 IS - 17 N2 - Red meat intake has been postulated to increase the risk of breast cancer but epidemiologic studies have yielded inconsistent results. Data on meat intake in relation to hormone receptor-defined breast cancer are sparse. We examined the association of meat intake with incidence of breast cancer defined by oestrogen receptor (ER) and progesterone receptor (PR) status in the Swedish Mammography Cohort, a population-based cohort of 61,433 women. Dietary intake was assessed at baseline in 1987-1990 and again in 1997. Cox proportional hazards models were used to estimate relative risks for the association between long-term meat intake and breast cancer risk. During a mean follow-up of 17.4 years, 2952 incident cases of invasive breast cancer were ascertained. We found no association of total red meat, fresh red meat or processed meat intake with breast cancer risk. The multivariate relative risks (95% confidence interval) for the highest quintile of total red meat intake (98 g/d) compared with the lowest quintile (<46 g/d) were 0.98 (0.86-1.12) for overall breast cancer, 1.10 (0.90-1.34) for ER+/PR+ tumours, 0.86 (0.60-1.23) for ER+/PR- tumours and 1.12 (0.70-1.79) for ER-/PR- tumours. Intake of pan-fried meat was positively associated with a risk of ER+/PR- tumours; the multivariate relative risk for the highest compared with the lowest quartile of intake was 1.45 (95% confidence interval 1.03-2.03; P(trend)=0.03). These results do not support an association between red meat intake and overall breast cancer risk but suggest that fried meat intake may increase the risk of ER+/PR- breast cancer. SN - 1879-0852 UR - https://www.unboundmedicine.com/medline/citation/19464165/Long_term_meat_intake_and_risk_of_breast_cancer_by_oestrogen_and_progesterone_receptor_status_in_a_cohort_of_Swedish_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0959-8049(09)00334-7 DB - PRIME DP - Unbound Medicine ER -