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Chronic treatment with tocotrienol, an isoform of vitamin E, prevents intracerebroventricular streptozotocin-induced cognitive impairment and oxidative-nitrosative stress in rats.
Pharmacol Biochem Behav. 2009 Aug; 93(2):183-9.PB

Abstract

Intracerebroventricular (ICV) streptozotocin (STZ) has been shown to cause cognitive impairment, which is associated with increased oxidative stress in the brain of rats. In the present study, we investigated the effect of both the isoforms of vitamin E, alpha-tocopherol and tocotrienol against ICV STZ-induced cognitive impairment and oxidative-nitrosative stress in rats. Adult male Wistar rats were injected with ICV STZ (3 mg/kg) bilaterally. The learning and memory behavior was assessed using Morris water maze and elevated plus maze. The rats were sacrificed on day 21 and parameters of oxidative stress, nitrite levels and acetylcholinesterase activity were measured in brain homogenate. alpha-Tocopherol as well as tocotrienol treated groups showed significantly less cognitive impairment in both the behavioral paradigms but the effect was more potent with tocotrienol. Both isoforms of vitamin E effectively attenuated the reduction in glutathione and catalase and reduced the malonaldehyde, nitrite as well as cholinesterase activity in the brains of ICV STZ rats in a dose dependent manner. The study demonstrates the effectiveness of vitamin E isoforms, of which tocotrienol being more potent in preventing the cognitive deficits caused by ICV STZ in rats and suggests its potential in the treatment of neurodegenerative diseases such as Alzheimer's disease.

Authors+Show Affiliations

Pharmacology Research Laboratory, University Institute of Pharmaceutical Sciences, UGC Center of Advanced Study, Panjab University, Chandigarh, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19464315

Citation

Tiwari, Vinod, et al. "Chronic Treatment With Tocotrienol, an Isoform of Vitamin E, Prevents Intracerebroventricular Streptozotocin-induced Cognitive Impairment and Oxidative-nitrosative Stress in Rats." Pharmacology, Biochemistry, and Behavior, vol. 93, no. 2, 2009, pp. 183-9.
Tiwari V, Kuhad A, Bishnoi M, et al. Chronic treatment with tocotrienol, an isoform of vitamin E, prevents intracerebroventricular streptozotocin-induced cognitive impairment and oxidative-nitrosative stress in rats. Pharmacol Biochem Behav. 2009;93(2):183-9.
Tiwari, V., Kuhad, A., Bishnoi, M., & Chopra, K. (2009). Chronic treatment with tocotrienol, an isoform of vitamin E, prevents intracerebroventricular streptozotocin-induced cognitive impairment and oxidative-nitrosative stress in rats. Pharmacology, Biochemistry, and Behavior, 93(2), 183-9. https://doi.org/10.1016/j.pbb.2009.05.009
Tiwari V, et al. Chronic Treatment With Tocotrienol, an Isoform of Vitamin E, Prevents Intracerebroventricular Streptozotocin-induced Cognitive Impairment and Oxidative-nitrosative Stress in Rats. Pharmacol Biochem Behav. 2009;93(2):183-9. PubMed PMID: 19464315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic treatment with tocotrienol, an isoform of vitamin E, prevents intracerebroventricular streptozotocin-induced cognitive impairment and oxidative-nitrosative stress in rats. AU - Tiwari,Vinod, AU - Kuhad,Anurag, AU - Bishnoi,Mahendra, AU - Chopra,Kanwaljit, Y1 - 2009/05/21/ PY - 2009/02/06/received PY - 2009/05/10/revised PY - 2009/05/18/accepted PY - 2009/5/26/entrez PY - 2009/5/26/pubmed PY - 2009/8/29/medline SP - 183 EP - 9 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 93 IS - 2 N2 - Intracerebroventricular (ICV) streptozotocin (STZ) has been shown to cause cognitive impairment, which is associated with increased oxidative stress in the brain of rats. In the present study, we investigated the effect of both the isoforms of vitamin E, alpha-tocopherol and tocotrienol against ICV STZ-induced cognitive impairment and oxidative-nitrosative stress in rats. Adult male Wistar rats were injected with ICV STZ (3 mg/kg) bilaterally. The learning and memory behavior was assessed using Morris water maze and elevated plus maze. The rats were sacrificed on day 21 and parameters of oxidative stress, nitrite levels and acetylcholinesterase activity were measured in brain homogenate. alpha-Tocopherol as well as tocotrienol treated groups showed significantly less cognitive impairment in both the behavioral paradigms but the effect was more potent with tocotrienol. Both isoforms of vitamin E effectively attenuated the reduction in glutathione and catalase and reduced the malonaldehyde, nitrite as well as cholinesterase activity in the brains of ICV STZ rats in a dose dependent manner. The study demonstrates the effectiveness of vitamin E isoforms, of which tocotrienol being more potent in preventing the cognitive deficits caused by ICV STZ in rats and suggests its potential in the treatment of neurodegenerative diseases such as Alzheimer's disease. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/19464315/Chronic_treatment_with_tocotrienol_an_isoform_of_vitamin_E_prevents_intracerebroventricular_streptozotocin_induced_cognitive_impairment_and_oxidative_nitrosative_stress_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(09)00161-0 DB - PRIME DP - Unbound Medicine ER -