Citation
Bargagli, E, et al. "Analysis of Macrophage Migration Inhibitory Factor (MIF) in Patients With Idiopathic Pulmonary Fibrosis." Respiratory Physiology & Neurobiology, vol. 167, no. 3, 2009, pp. 261-7.
Bargagli E, Olivieri C, Nikiforakis N, et al. Analysis of macrophage migration inhibitory factor (MIF) in patients with idiopathic pulmonary fibrosis. Respir Physiol Neurobiol. 2009;167(3):261-7.
Bargagli, E., Olivieri, C., Nikiforakis, N., Cintorino, M., Magi, B., Perari, M. G., Vagaggini, C., Spina, D., Prasse, A., & Rottoli, P. (2009). Analysis of macrophage migration inhibitory factor (MIF) in patients with idiopathic pulmonary fibrosis. Respiratory Physiology & Neurobiology, 167(3), 261-7. https://doi.org/10.1016/j.resp.2009.05.004
Bargagli E, et al. Analysis of Macrophage Migration Inhibitory Factor (MIF) in Patients With Idiopathic Pulmonary Fibrosis. Respir Physiol Neurobiol. 2009 Jul 31;167(3):261-7. PubMed PMID: 19464392.
TY - JOUR
T1 - Analysis of macrophage migration inhibitory factor (MIF) in patients with idiopathic pulmonary fibrosis.
AU - Bargagli,E,
AU - Olivieri,C,
AU - Nikiforakis,N,
AU - Cintorino,M,
AU - Magi,B,
AU - Perari,M G,
AU - Vagaggini,C,
AU - Spina,D,
AU - Prasse,A,
AU - Rottoli,P,
Y1 - 2009/05/21/
PY - 2009/01/12/received
PY - 2009/05/12/revised
PY - 2009/05/13/accepted
PY - 2009/5/26/entrez
PY - 2009/5/26/pubmed
PY - 2009/9/30/medline
SP - 261
EP - 7
JF - Respiratory physiology & neurobiology
JO - Respir Physiol Neurobiol
VL - 167
IS - 3
N2 - By proteomic approach we previously characterised bronchoalveolar lavage (BAL) protein profiles of patients with idiopathic pulmonary fibrosis (IPF), sarcoidosis and systemic sclerosis. Among differently expressed proteins we identified macrophage migration inhibitory factor (MIF), a multi-function pleiotropic cytokine. This study was performed to validate our findings by a further proteomic approach and ELISA in a larger population of patients and controls. MIF expression in lung tissue was also evaluated by immunohistochemistry. MIF was identified in all 2-DE gels of IPF patients and it was significantly increased compared to controls (p<0.05). This result was confirmed by ELISA: MIF concentrations were significantly higher in IPF patients than controls (p<0.001) and were directly correlated with neutrophil percentages (p=0.0095). Immunohistochemical analysis revealed enhanced expression in bronchiolar epithelium, alveolar epithelium, and fibroblastic foci. In conclusion, MIF is a pleiotropic cytokine that could be involved in the pathogenesis of IPF, being particularly abundant in BAL of these patients and mainly expressed in the areas of active fibrosis.
SN - 1878-1519
UR - https://www.unboundmedicine.com/medline/citation/19464392/Analysis_of_macrophage_migration_inhibitory_factor__MIF__in_patients_with_idiopathic_pulmonary_fibrosis_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S1569-9048(09)00143-8
DB - PRIME
DP - Unbound Medicine
ER -