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Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women.
Environ Res 2009; 109(6):797-801ER

Abstract

Bisphenol A (BPA) is widely used in the production of polycarbonate plastics and epoxy resins. There is increasing health concerns regarding low-level exposure to BPA among the general population. The aim of this study was to determine the association between BPA exposure with oxidative stress and inflammation in adult populations. A cross-sectional study was conducted. This study included 485 adults (259 men, 92 premenopausal women, and 134 postmenopausal women) living in general communities within large cities. Urinary concentrations of BPA, malondialdehyde (MDA), and 8-hydroxydeoxyguanosine (8-OHdG), white blood cell (WBC) count, and C-reactive protein (CRP) were measured. Multivariate analyses were applied to determine the associations of BPA exposure with oxidative stress and inflammation. The geometric means of urinary BPA for men, premenopausal women, and postmenopausal women were 0.53, 0.61, and 0.58 microg/g cr, respectively. The urinary BPA concentrations were positively associated with MDA, 8-OHdG, and CRP levels in the postmenopausal women; however, such associations did not exist in men and premenopausal women. The findings of this study suggest that BPA exposure would promote oxidative stress and inflammation, in which postmenopausal women are likely to be more susceptible to BPA-induced health effects.

Authors+Show Affiliations

Department of Preventive Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19464675

Citation

Yang, Yoon Jung, et al. "Bisphenol a Exposure Is Associated With Oxidative Stress and Inflammation in Postmenopausal Women." Environmental Research, vol. 109, no. 6, 2009, pp. 797-801.
Yang YJ, Hong YC, Oh SY, et al. Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women. Environ Res. 2009;109(6):797-801.
Yang, Y. J., Hong, Y. C., Oh, S. Y., Park, M. S., Kim, H., Leem, J. H., & Ha, E. H. (2009). Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women. Environmental Research, 109(6), pp. 797-801. doi:10.1016/j.envres.2009.04.014.
Yang YJ, et al. Bisphenol a Exposure Is Associated With Oxidative Stress and Inflammation in Postmenopausal Women. Environ Res. 2009;109(6):797-801. PubMed PMID: 19464675.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women. AU - Yang,Yoon Jung, AU - Hong,Yun-Chul, AU - Oh,Se-Young, AU - Park,Min-Seon, AU - Kim,Ho, AU - Leem,Jong-Han, AU - Ha,Eun-Hee, Y1 - 2009/05/22/ PY - 2009/01/05/received PY - 2009/04/24/revised PY - 2009/04/27/accepted PY - 2009/5/26/entrez PY - 2009/5/26/pubmed PY - 2009/7/18/medline SP - 797 EP - 801 JF - Environmental research JO - Environ. Res. VL - 109 IS - 6 N2 - Bisphenol A (BPA) is widely used in the production of polycarbonate plastics and epoxy resins. There is increasing health concerns regarding low-level exposure to BPA among the general population. The aim of this study was to determine the association between BPA exposure with oxidative stress and inflammation in adult populations. A cross-sectional study was conducted. This study included 485 adults (259 men, 92 premenopausal women, and 134 postmenopausal women) living in general communities within large cities. Urinary concentrations of BPA, malondialdehyde (MDA), and 8-hydroxydeoxyguanosine (8-OHdG), white blood cell (WBC) count, and C-reactive protein (CRP) were measured. Multivariate analyses were applied to determine the associations of BPA exposure with oxidative stress and inflammation. The geometric means of urinary BPA for men, premenopausal women, and postmenopausal women were 0.53, 0.61, and 0.58 microg/g cr, respectively. The urinary BPA concentrations were positively associated with MDA, 8-OHdG, and CRP levels in the postmenopausal women; however, such associations did not exist in men and premenopausal women. The findings of this study suggest that BPA exposure would promote oxidative stress and inflammation, in which postmenopausal women are likely to be more susceptible to BPA-induced health effects. SN - 1096-0953 UR - https://www.unboundmedicine.com/medline/citation/19464675/Bisphenol_A_exposure_is_associated_with_oxidative_stress_and_inflammation_in_postmenopausal_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(09)00084-X DB - PRIME DP - Unbound Medicine ER -