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No association between gastric fundic gland polyps and gastrointestinal neoplasia in a study of over 100,000 patients.
Clin Gastroenterol Hepatol. 2009 Aug; 7(8):849-54.CG

Abstract

BACKGROUND & AIMS

Fundic gland polyps (FGPs), the most common type of gastric polyps, have been associated with prolonged proton pump inhibitor therapy and an increased risk of colon cancer. The presence of FGPs has been inversely correlated with Helicobacter pylori infection. We evaluated the prevalence of H pylori-associated gastritis, colonic polyps, and carcinomas in subjects with and without FGPs.

METHODS

We analyzed data collected from community-based endoscopy centers in 36 states (plus Washington DC and Puerto Rico) on patients who underwent esophagogastroduodenoscopy (EGD) and colonoscopy between April 2007 and March 2008. Of the 103,385 patients who underwent EGD during this time period, gastric biopsy samples were collected from 78,801 and colonic biopsies from 26,017. Slides of samples from Helicobacter-infected FGPs and FGPs with dysplasia were reviewed.

RESULTS

FGPs were detected in 6081 patients (67.8% women). Helicobacter infection was present in less than 0.5% patients with FGPs and 13.0% of those without FGPs (odds ratio [OR], 29.05; 95% confidence interval [CI], 20.4-41.4; P < .0001). Colonic adenomas were detected in 42.3% of women with FGPs and 33.8% of those without (OR, 1.43; 95% CI, 1.26-1.63; P < .001); there was no significant difference in colonic adenomas between men with and without FGPs.

CONCLUSIONS

Women had a higher prevalence of FGPs. FGPs were associated with gastroesophageal reflux disease symptoms, gastric heterotopia, hyperplastic colonic polyps (only in men), and colonic adenomas (only in women, especially those over 60 years of age). The presence of FGPs was inversely correlated with H pylori infection, active gastritis, and gastric neoplasia.

Authors+Show Affiliations

Division of Gastrointestinal Pathology, Caris Diagnostics, Irving, Texas, USA. robert.genta@utsouthwestern.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19465154

Citation

Genta, Robert M., et al. "No Association Between Gastric Fundic Gland Polyps and Gastrointestinal Neoplasia in a Study of Over 100,000 Patients." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, vol. 7, no. 8, 2009, pp. 849-54.
Genta RM, Schuler CM, Robiou CI, et al. No association between gastric fundic gland polyps and gastrointestinal neoplasia in a study of over 100,000 patients. Clin Gastroenterol Hepatol. 2009;7(8):849-54.
Genta, R. M., Schuler, C. M., Robiou, C. I., & Lash, R. H. (2009). No association between gastric fundic gland polyps and gastrointestinal neoplasia in a study of over 100,000 patients. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 7(8), 849-54. https://doi.org/10.1016/j.cgh.2009.05.015
Genta RM, et al. No Association Between Gastric Fundic Gland Polyps and Gastrointestinal Neoplasia in a Study of Over 100,000 Patients. Clin Gastroenterol Hepatol. 2009;7(8):849-54. PubMed PMID: 19465154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No association between gastric fundic gland polyps and gastrointestinal neoplasia in a study of over 100,000 patients. AU - Genta,Robert M, AU - Schuler,Christopher M, AU - Robiou,Cristian I, AU - Lash,Richard H, Y1 - 2009/05/22/ PY - 2009/04/05/received PY - 2009/05/06/revised PY - 2009/05/10/accepted PY - 2009/5/26/entrez PY - 2009/5/26/pubmed PY - 2009/9/29/medline SP - 849 EP - 54 JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JO - Clin Gastroenterol Hepatol VL - 7 IS - 8 N2 - BACKGROUND & AIMS: Fundic gland polyps (FGPs), the most common type of gastric polyps, have been associated with prolonged proton pump inhibitor therapy and an increased risk of colon cancer. The presence of FGPs has been inversely correlated with Helicobacter pylori infection. We evaluated the prevalence of H pylori-associated gastritis, colonic polyps, and carcinomas in subjects with and without FGPs. METHODS: We analyzed data collected from community-based endoscopy centers in 36 states (plus Washington DC and Puerto Rico) on patients who underwent esophagogastroduodenoscopy (EGD) and colonoscopy between April 2007 and March 2008. Of the 103,385 patients who underwent EGD during this time period, gastric biopsy samples were collected from 78,801 and colonic biopsies from 26,017. Slides of samples from Helicobacter-infected FGPs and FGPs with dysplasia were reviewed. RESULTS: FGPs were detected in 6081 patients (67.8% women). Helicobacter infection was present in less than 0.5% patients with FGPs and 13.0% of those without FGPs (odds ratio [OR], 29.05; 95% confidence interval [CI], 20.4-41.4; P < .0001). Colonic adenomas were detected in 42.3% of women with FGPs and 33.8% of those without (OR, 1.43; 95% CI, 1.26-1.63; P < .001); there was no significant difference in colonic adenomas between men with and without FGPs. CONCLUSIONS: Women had a higher prevalence of FGPs. FGPs were associated with gastroesophageal reflux disease symptoms, gastric heterotopia, hyperplastic colonic polyps (only in men), and colonic adenomas (only in women, especially those over 60 years of age). The presence of FGPs was inversely correlated with H pylori infection, active gastritis, and gastric neoplasia. SN - 1542-7714 UR - https://www.unboundmedicine.com/medline/citation/19465154/No_association_between_gastric_fundic_gland_polyps_and_gastrointestinal_neoplasia_in_a_study_of_over_100000_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1542-3565(09)00448-0 DB - PRIME DP - Unbound Medicine ER -