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Hormonal management of migraine at menopause.
Menopause Int. 2009 Jun; 15(2):82-6.MI

Abstract

In this review, we underline the importance of linking migraine to reproductive stages for optimal management of such a common disease across the lifespan of women. Menopause has a variable effect on migraine depending on individual vulnerability to neuroendocrine changes induced by estrogen fluctuations and on the length of menopausal transition. Indeed, an association between estrogen 'milieu' and attacks of migraine is strongly supported by several lines of evidence. During the perimenopause, it is likely to observe a worsening of migraine, and a tailored hormonal replacement therapy (HRT) to minimize estrogen/progesterone imbalance may be effective. In the natural menopause, women experience a more favourable course of migraine in comparison with those who have surgical menopause. When severe climacteric symptoms are present, postmenopausal women may be treated with continuous HRT. Even tibolone may be useful when analgesic overuse is documented. However, the transdermal route of oestradiol administration in the lowest effective dose should be preferred to avoid potential vascular risk.

Authors+Show Affiliations

Department of Morphological, Etiological and Clinical Sciences, Research Center of Reproductive Medicine, University of Pavia, Via Ferrata 8, 27100 Pavia, Italy. renappi@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19465675

Citation

Nappi, Rossella E., et al. "Hormonal Management of Migraine at Menopause." Menopause International, vol. 15, no. 2, 2009, pp. 82-6.
Nappi RE, Sances G, Detaddei S, et al. Hormonal management of migraine at menopause. Menopause Int. 2009;15(2):82-6.
Nappi, R. E., Sances, G., Detaddei, S., Ornati, A., Chiovato, L., & Polatti, F. (2009). Hormonal management of migraine at menopause. Menopause International, 15(2), 82-6. https://doi.org/10.1258/mi.2009.009022
Nappi RE, et al. Hormonal Management of Migraine at Menopause. Menopause Int. 2009;15(2):82-6. PubMed PMID: 19465675.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hormonal management of migraine at menopause. AU - Nappi,Rossella E, AU - Sances,Grazia, AU - Detaddei,Silvia, AU - Ornati,Alessandra, AU - Chiovato,Luca, AU - Polatti,Franco, PY - 2009/5/26/entrez PY - 2009/5/26/pubmed PY - 2009/10/6/medline SP - 82 EP - 6 JF - Menopause international JO - Menopause Int VL - 15 IS - 2 N2 - In this review, we underline the importance of linking migraine to reproductive stages for optimal management of such a common disease across the lifespan of women. Menopause has a variable effect on migraine depending on individual vulnerability to neuroendocrine changes induced by estrogen fluctuations and on the length of menopausal transition. Indeed, an association between estrogen 'milieu' and attacks of migraine is strongly supported by several lines of evidence. During the perimenopause, it is likely to observe a worsening of migraine, and a tailored hormonal replacement therapy (HRT) to minimize estrogen/progesterone imbalance may be effective. In the natural menopause, women experience a more favourable course of migraine in comparison with those who have surgical menopause. When severe climacteric symptoms are present, postmenopausal women may be treated with continuous HRT. Even tibolone may be useful when analgesic overuse is documented. However, the transdermal route of oestradiol administration in the lowest effective dose should be preferred to avoid potential vascular risk. SN - 1754-0453 UR - https://www.unboundmedicine.com/medline/citation/19465675/Hormonal_management_of_migraine_at_menopause_ L2 - http://www.diseaseinfosearch.org/result/4811 DB - PRIME DP - Unbound Medicine ER -