TY - JOUR T1 - Electropolymerized film of functionalized thiadiazole on glassy carbon electrode for the simultaneous determination of ascorbic acid, dopamine and uric acid. AU - Kalimuthu,Palraj, AU - John,S Abraham, Y1 - 2009/05/08/ PY - 2009/01/31/received PY - 2009/04/28/revised PY - 2009/04/29/accepted PY - 2009/5/27/entrez PY - 2009/5/27/pubmed PY - 2010/2/26/medline SP - 13 EP - 8 JF - Bioelectrochemistry (Amsterdam, Netherlands) JO - Bioelectrochemistry VL - 77 IS - 1 N2 - The present study reports the simultaneous determination of ascorbic acid (AA), dopamine (DA) and uric acid (UA) in 0.20 M phosphate buffer solution (pH 5.0) using electropolymerized ultrathin film of 5-amino-2-mercapto-1,3,4-thiadiazole (AMT) on glassy carbon (GC) electrode. The bare GC electrode does not separate the voltammetric signals of AA, DA and UA. However, electropolymerized AMT (p-AMT) modified GC electrode not only resolved the voltammetric signals of AA, DA and UA but also dramatically enhanced their oxidation peak currents when compared to bare GC electrode. The enhanced oxidation currents for AA, DA and UA at p-AMT modified electrode are due to the electrostatic interactions between them and the polymer film. Using amperometric method, we achieved the lowest detection of 75 nM AA, 40 nM DA and 60 nM UA at p-AMT modified electrode. The amperometric current was linearly increased from 200 nM to 0.80 mM for each AA, DA and UA and the lowest detection limit was found to be 0.92, 0.07 and 0.57 nM, respectively (S/N=3). The practical application of the modified electrode was demonstrated by the determination of DA in dopamine hydrochloride injection. SN - 1878-562X UR - https://www.unboundmedicine.com/medline/citation/19467620/Electropolymerized_film_of_functionalized_thiadiazole_on_glassy_carbon_electrode_for_the_simultaneous_determination_of_ascorbic_acid_dopamine_and_uric_acid_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5394(09)00088-7 DB - PRIME DP - Unbound Medicine ER -