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The role of anger in adherence to highly active antiretroviral treatment in patients infected with HIV.
Psychother Psychosom. 2009; 78(4):254-7.PP

Abstract

BACKGROUND

Adherence to highly active antiretroviral treatment (HAART) is critical to long-term treatment success in patients infected with human immunodeficiency virus (HIV). However, the relationship between psychological variables and medication adherence is still poorly understood. The aim of this study was to investigate how anger dimensions in subjects with HIV affect adherence to antiretroviral drugs.

METHODS

One hundred and thirty outpatients with HIV who were nondepressed and receiving HAART were administered the State-Trait Anger Inventory and a compliance self-report questionnaire. They also underwent clinical laboratory tests aimed at investigating immune function and disease stage.

RESULTS

Forty-three patients (33%) reported suboptimal adherence. Full compliance with HAART was related to higher age, lower HIV RNA level, lower trait anger, lower outside-directed anger and greater anger control. In a multiple regression analysis, low trait anger (p = 0.02) and high anger control (p = 0.03) were significantly associated with full adherence to HAART.

CONCLUSIONS

Anger dimensions are linked with, and may affect, adherence to HAART. A better understanding of the psychological determinants of compliance might allow for the identification of patients who are at higher risk of nonadherence. To sustain adherence to HAART, these patients may benefit from increased clinical attention or intervention.

Authors+Show Affiliations

Neuroscience Department, Psychiatry Section, University of Torino, Torino, Italy. paolo.leombruni@unito.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19468260

Citation

Leombruni, Paolo, et al. "The Role of Anger in Adherence to Highly Active Antiretroviral Treatment in Patients Infected With HIV." Psychotherapy and Psychosomatics, vol. 78, no. 4, 2009, pp. 254-7.
Leombruni P, Fassino S, Lavagnino L, et al. The role of anger in adherence to highly active antiretroviral treatment in patients infected with HIV. Psychother Psychosom. 2009;78(4):254-7.
Leombruni, P., Fassino, S., Lavagnino, L., Orofino, G., Morosini, P., & Picardi, A. (2009). The role of anger in adherence to highly active antiretroviral treatment in patients infected with HIV. Psychotherapy and Psychosomatics, 78(4), 254-7. https://doi.org/10.1159/000219525
Leombruni P, et al. The Role of Anger in Adherence to Highly Active Antiretroviral Treatment in Patients Infected With HIV. Psychother Psychosom. 2009;78(4):254-7. PubMed PMID: 19468260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of anger in adherence to highly active antiretroviral treatment in patients infected with HIV. AU - Leombruni,Paolo, AU - Fassino,Secondo, AU - Lavagnino,Luca, AU - Orofino,Giancarlo, AU - Morosini,Pierluigi, AU - Picardi,Angelo, Y1 - 2009/05/21/ PY - 2007/09/09/received PY - 2008/06/16/accepted PY - 2009/5/27/entrez PY - 2009/5/27/pubmed PY - 2009/8/22/medline SP - 254 EP - 7 JF - Psychotherapy and psychosomatics JO - Psychother Psychosom VL - 78 IS - 4 N2 - BACKGROUND: Adherence to highly active antiretroviral treatment (HAART) is critical to long-term treatment success in patients infected with human immunodeficiency virus (HIV). However, the relationship between psychological variables and medication adherence is still poorly understood. The aim of this study was to investigate how anger dimensions in subjects with HIV affect adherence to antiretroviral drugs. METHODS: One hundred and thirty outpatients with HIV who were nondepressed and receiving HAART were administered the State-Trait Anger Inventory and a compliance self-report questionnaire. They also underwent clinical laboratory tests aimed at investigating immune function and disease stage. RESULTS: Forty-three patients (33%) reported suboptimal adherence. Full compliance with HAART was related to higher age, lower HIV RNA level, lower trait anger, lower outside-directed anger and greater anger control. In a multiple regression analysis, low trait anger (p = 0.02) and high anger control (p = 0.03) were significantly associated with full adherence to HAART. CONCLUSIONS: Anger dimensions are linked with, and may affect, adherence to HAART. A better understanding of the psychological determinants of compliance might allow for the identification of patients who are at higher risk of nonadherence. To sustain adherence to HAART, these patients may benefit from increased clinical attention or intervention. SN - 1423-0348 UR - https://www.unboundmedicine.com/medline/citation/19468260/The_role_of_anger_in_adherence_to_highly_active_antiretroviral_treatment_in_patients_infected_with_HIV_ L2 - https://www.karger.com?DOI=10.1159/000219525 DB - PRIME DP - Unbound Medicine ER -