Tags

Type your tag names separated by a space and hit enter

Relationship between impulse oscillometry and spirometric indices in cystic fibrosis children.
Acta Paediatr. 2009 Jun; 98(6):1019-23.AP

Abstract

BACKGROUND

The aim of our retrospective study was to determine the relationship between impulse oscillometry (IOS) data and spirometric tests in cystic fibrosis (CF) children. methods: Thirty CF children aged 4-19 years have performed lung function tests (LFT). A subset of 15 patients repeated LFT on five separate occasions. IOS parameters were respiratory resistance (Rrs), reactance (Xrs) and impedance at 5 Hz (R5, X5, Zr) and the resonant frequency (Fres). Spirometry indices (SI) included forced expiratory volume in 1 sec (FEV(1)), forced expiratory flow during the middle half of FVC (FEF(25-75)) and forced vital capacity (FVC).

RESULTS

An inverse relationship was observed between raw values of R5, Zr, Fres and SI respectively, and X5 correlated positively with SI. Although significant, these correlations were poor. Receiver operating characteristic curves (ROC) were constructed to identify cutoff points for IOS parameters to discriminate between children according to predefined FEV(1) thresholds (percent predicted), generally used to categorize the level of lung function impairment. No acceptable cutoff points can be found for IOS parameters. Trends analyses in the subgroup of 15 patients showed a significant decline of FEV(1) between the first and the fifth evaluation. None of the IOS indices demonstrated a consistent tendency, apart from a slight decrease of Fres.

CONCLUSION

IOS measurements presented an insufficient sensitivity to detect and follow bronchial obstruction in CF patients.

Authors+Show Affiliations

Pulmonary Function Tests laboratory, Department of Pediatrics, Hospital Archet II, University of Nice Sofia Antipolis, Nice, France. moreau.l@chu-nice.frNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19469720

Citation

Moreau, Ludovic, et al. "Relationship Between Impulse Oscillometry and Spirometric Indices in Cystic Fibrosis Children." Acta Paediatrica (Oslo, Norway : 1992), vol. 98, no. 6, 2009, pp. 1019-23.
Moreau L, Crenesse D, Berthier F, et al. Relationship between impulse oscillometry and spirometric indices in cystic fibrosis children. Acta Paediatr. 2009;98(6):1019-23.
Moreau, L., Crenesse, D., Berthier, F., & Albertini, M. (2009). Relationship between impulse oscillometry and spirometric indices in cystic fibrosis children. Acta Paediatrica (Oslo, Norway : 1992), 98(6), 1019-23. https://doi.org/10.1111/j.1651-2227.2009.01246.x
Moreau L, et al. Relationship Between Impulse Oscillometry and Spirometric Indices in Cystic Fibrosis Children. Acta Paediatr. 2009;98(6):1019-23. PubMed PMID: 19469720.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between impulse oscillometry and spirometric indices in cystic fibrosis children. AU - Moreau,Ludovic, AU - Crenesse,Dominique, AU - Berthier,Frederic, AU - Albertini,Marc, Y1 - 2009/05/12/ PY - 2009/5/28/entrez PY - 2009/5/28/pubmed PY - 2009/8/20/medline SP - 1019 EP - 23 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr. VL - 98 IS - 6 N2 - BACKGROUND: The aim of our retrospective study was to determine the relationship between impulse oscillometry (IOS) data and spirometric tests in cystic fibrosis (CF) children. methods: Thirty CF children aged 4-19 years have performed lung function tests (LFT). A subset of 15 patients repeated LFT on five separate occasions. IOS parameters were respiratory resistance (Rrs), reactance (Xrs) and impedance at 5 Hz (R5, X5, Zr) and the resonant frequency (Fres). Spirometry indices (SI) included forced expiratory volume in 1 sec (FEV(1)), forced expiratory flow during the middle half of FVC (FEF(25-75)) and forced vital capacity (FVC). RESULTS: An inverse relationship was observed between raw values of R5, Zr, Fres and SI respectively, and X5 correlated positively with SI. Although significant, these correlations were poor. Receiver operating characteristic curves (ROC) were constructed to identify cutoff points for IOS parameters to discriminate between children according to predefined FEV(1) thresholds (percent predicted), generally used to categorize the level of lung function impairment. No acceptable cutoff points can be found for IOS parameters. Trends analyses in the subgroup of 15 patients showed a significant decline of FEV(1) between the first and the fifth evaluation. None of the IOS indices demonstrated a consistent tendency, apart from a slight decrease of Fres. CONCLUSION: IOS measurements presented an insufficient sensitivity to detect and follow bronchial obstruction in CF patients. SN - 1651-2227 UR - https://www.unboundmedicine.com/medline/citation/19469720/Relationship_between_impulse_oscillometry_and_spirometric_indices_in_cystic_fibrosis_children_ L2 - https://doi.org/10.1111/j.1651-2227.2009.01246.x DB - PRIME DP - Unbound Medicine ER -