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Identifying new cannabis use with urine creatinine-normalized THCCOOH concentrations and time intervals between specimen collections.
J Anal Toxicol 2009; 33(4):185-9JA

Abstract

A previously recommended method for detecting new cannabis use with creatinine-normalized 11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol (THCCOOH) urine concentrations in periodically collected specimens for treatment, workplace and judicial drug testing applications is refined by considering the time interval between urine collections. All urine specimens were collected from six less-than-daily cannabis users who smoked placebo, 1.75%, and 3.55% THC cigarettes in randomized order, each separated by one week. Ratios (n = 24,322) were calculated by dividing each creatinine-normalized THCCOOH concentration (U2) by that of a previously collected specimen (U1). Maximum, 95% limit, and median U2/U1 ratios with 15 and 6 ng THCCOOH/mL cutoff concentrations, with and without new use between specimens, were calculated for each 24-h interval after smoking up to 168 h and are included in tables. These ratios decreased with increasing interval between collections providing improved decision values for determining new cannabis use. For example, with a 15 ng THCCOOH/mL cutoff concentration and no new use between specimens, the maximum, 95% limit, and median U2/U1 ratios were 3.05, 1.59, and 0.686, respectively, when the collection interval was <or = 24 h and 0.215, 0.135, and 0.085 when it was 96-119.9 h.

Authors+Show Affiliations

Armed Forces Medical Examiner System, Armed Forces Institute of Pathology, Rockville, Maryland 20850, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19470219

Citation

Smith, Michael L., et al. "Identifying New Cannabis Use With Urine Creatinine-normalized THCCOOH Concentrations and Time Intervals Between Specimen Collections." Journal of Analytical Toxicology, vol. 33, no. 4, 2009, pp. 185-9.
Smith ML, Barnes AJ, Huestis MA. Identifying new cannabis use with urine creatinine-normalized THCCOOH concentrations and time intervals between specimen collections. J Anal Toxicol. 2009;33(4):185-9.
Smith, M. L., Barnes, A. J., & Huestis, M. A. (2009). Identifying new cannabis use with urine creatinine-normalized THCCOOH concentrations and time intervals between specimen collections. Journal of Analytical Toxicology, 33(4), pp. 185-9.
Smith ML, Barnes AJ, Huestis MA. Identifying New Cannabis Use With Urine Creatinine-normalized THCCOOH Concentrations and Time Intervals Between Specimen Collections. J Anal Toxicol. 2009;33(4):185-9. PubMed PMID: 19470219.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identifying new cannabis use with urine creatinine-normalized THCCOOH concentrations and time intervals between specimen collections. AU - Smith,Michael L, AU - Barnes,Allan J, AU - Huestis,Marilyn A, PY - 2009/5/28/entrez PY - 2009/5/28/pubmed PY - 2009/7/14/medline SP - 185 EP - 9 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 33 IS - 4 N2 - A previously recommended method for detecting new cannabis use with creatinine-normalized 11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol (THCCOOH) urine concentrations in periodically collected specimens for treatment, workplace and judicial drug testing applications is refined by considering the time interval between urine collections. All urine specimens were collected from six less-than-daily cannabis users who smoked placebo, 1.75%, and 3.55% THC cigarettes in randomized order, each separated by one week. Ratios (n = 24,322) were calculated by dividing each creatinine-normalized THCCOOH concentration (U2) by that of a previously collected specimen (U1). Maximum, 95% limit, and median U2/U1 ratios with 15 and 6 ng THCCOOH/mL cutoff concentrations, with and without new use between specimens, were calculated for each 24-h interval after smoking up to 168 h and are included in tables. These ratios decreased with increasing interval between collections providing improved decision values for determining new cannabis use. For example, with a 15 ng THCCOOH/mL cutoff concentration and no new use between specimens, the maximum, 95% limit, and median U2/U1 ratios were 3.05, 1.59, and 0.686, respectively, when the collection interval was <or = 24 h and 0.215, 0.135, and 0.085 when it was 96-119.9 h. SN - 0146-4760 UR - https://www.unboundmedicine.com/medline/citation/19470219/abstract/Identifying_New_Cannabis_Use_with_Urine_Creatinine_Normalized_THCCOOH_Concentrations_and_Time_Intervals_Between_Specimen_Collections_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/33.4.185 DB - PRIME DP - Unbound Medicine ER -