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Lifelong cancer incidence in 47,697 patients treated for childhood cancer in the Nordic countries.
J Natl Cancer Inst. 2009 Jun 03; 101(11):806-13.JNCI

Abstract

BACKGROUND

The pattern of cancer in long-term survivors from childhood cancer has not been investigated comprehensively.

METHODS

We obtained a cohort of 47,697 children and adolescents aged 0-19 years with cancer as defined by the country-wide cancer registries of Denmark, Finland, Iceland, Norway, and Sweden during 1943-2005. Cohort members were followed through age 79 years for subsequent primary cancers notified to the registries, and the age-specific risk pattern of the survivors was compared with that of the national populations using country and sex standardized incidence ratios (SIRs). We used a multiplicative Poisson regression model to estimate relative risk of cancer for attained age, with adjustment for calendar period and age at diagnosis of primary cancer. We also calculated excess absolute risk (EAR) attributable to status as childhood cancer survivor and determined the cumulative incidence of second primary cancer as a function of attained age for three subcohorts defined by period of treatment for childhood cancer.

RESULTS

A total of 1180 asynchronous second primary cancers were observed in 1088 persons, yielding an overall SIR of 3.3 (95% confidence interval = 3.1 to 3.5). The relative risk was statistically significantly increased in all age groups, even for cohort members approaching 70 years of age. The EAR for second primary cancer among survivors increased gradually from one additional case per 1000 person-years of observation in early life to six additional cases per 1000 person-years in the age group 60-69 years. For children treated in the prechemotherapy era (1943-1959), the cumulative risk for a second primary cancer reached 18%, 34%, and 48% at ages 60, 70, and 80 years, respectively. The age-specific incidence rates were highest for cohort members treated in the era of intensive, multiple-agent chemotherapy (1975-2005).

CONCLUSION

Survivors of childhood cancer have a persistent excess risk for a second primary cancer throughout their lives, accompanied by continuous changes in the risk of cancers at specific sites.

Authors+Show Affiliations

Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. jorgen@cancer.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19470947

Citation

Olsen, Jørgen H., et al. "Lifelong Cancer Incidence in 47,697 Patients Treated for Childhood Cancer in the Nordic Countries." Journal of the National Cancer Institute, vol. 101, no. 11, 2009, pp. 806-13.
Olsen JH, Möller T, Anderson H, et al. Lifelong cancer incidence in 47,697 patients treated for childhood cancer in the Nordic countries. J Natl Cancer Inst. 2009;101(11):806-13.
Olsen, J. H., Möller, T., Anderson, H., Langmark, F., Sankila, R., Tryggvadóttír, L., Winther, J. F., Rechnitzer, C., Jonmundsson, G., Christensen, J., & Garwicz, S. (2009). Lifelong cancer incidence in 47,697 patients treated for childhood cancer in the Nordic countries. Journal of the National Cancer Institute, 101(11), 806-13. https://doi.org/10.1093/jnci/djp104
Olsen JH, et al. Lifelong Cancer Incidence in 47,697 Patients Treated for Childhood Cancer in the Nordic Countries. J Natl Cancer Inst. 2009 Jun 3;101(11):806-13. PubMed PMID: 19470947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lifelong cancer incidence in 47,697 patients treated for childhood cancer in the Nordic countries. AU - Olsen,Jørgen H, AU - Möller,Torgil, AU - Anderson,Harald, AU - Langmark,Frøydis, AU - Sankila,Risto, AU - Tryggvadóttír,Laufey, AU - Winther,Jeanette Falck, AU - Rechnitzer,Catherine, AU - Jonmundsson,Gudmundur, AU - Christensen,Jane, AU - Garwicz,Stanislaw, Y1 - 2009/05/26/ PY - 2009/5/28/entrez PY - 2009/5/28/pubmed PY - 2009/6/19/medline SP - 806 EP - 13 JF - Journal of the National Cancer Institute JO - J Natl Cancer Inst VL - 101 IS - 11 N2 - BACKGROUND: The pattern of cancer in long-term survivors from childhood cancer has not been investigated comprehensively. METHODS: We obtained a cohort of 47,697 children and adolescents aged 0-19 years with cancer as defined by the country-wide cancer registries of Denmark, Finland, Iceland, Norway, and Sweden during 1943-2005. Cohort members were followed through age 79 years for subsequent primary cancers notified to the registries, and the age-specific risk pattern of the survivors was compared with that of the national populations using country and sex standardized incidence ratios (SIRs). We used a multiplicative Poisson regression model to estimate relative risk of cancer for attained age, with adjustment for calendar period and age at diagnosis of primary cancer. We also calculated excess absolute risk (EAR) attributable to status as childhood cancer survivor and determined the cumulative incidence of second primary cancer as a function of attained age for three subcohorts defined by period of treatment for childhood cancer. RESULTS: A total of 1180 asynchronous second primary cancers were observed in 1088 persons, yielding an overall SIR of 3.3 (95% confidence interval = 3.1 to 3.5). The relative risk was statistically significantly increased in all age groups, even for cohort members approaching 70 years of age. The EAR for second primary cancer among survivors increased gradually from one additional case per 1000 person-years of observation in early life to six additional cases per 1000 person-years in the age group 60-69 years. For children treated in the prechemotherapy era (1943-1959), the cumulative risk for a second primary cancer reached 18%, 34%, and 48% at ages 60, 70, and 80 years, respectively. The age-specific incidence rates were highest for cohort members treated in the era of intensive, multiple-agent chemotherapy (1975-2005). CONCLUSION: Survivors of childhood cancer have a persistent excess risk for a second primary cancer throughout their lives, accompanied by continuous changes in the risk of cancers at specific sites. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/19470947/Lifelong_cancer_incidence_in_47697_patients_treated_for_childhood_cancer_in_the_Nordic_countries_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djp104 DB - PRIME DP - Unbound Medicine ER -