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Muscle mass and functional correlates of insulin sensitivity in lean young Indian men.
Eur J Clin Nutr. 2009 Oct; 63(10):1206-12.EJ

Abstract

BACKGROUND/OBJECTIVES

There is a high prevalence of diabetes mellitus associated with insulin resistance in Indian adults, probably due to an inappropriately high accumulation of body fat at lower body mass indices (BMIs, kg/m(2)), as well as to a lower skeletal muscle mass. Although skeletal muscle is an important site of glucose disposal, the strength of its association with insulin sensitivity (IS) is unknown in the Indian population.

SUBJECTS/METHODS

This was a cross-sectional study performed to assess the association of body fat, muscle and muscle function with IS in 51 young, healthy, nonobese Indian men with BMI ranging from 15 to 25 kg/m(2), using hyperinsulinemic euglycemic clamp method.

RESULTS

The median IS was 5.32 (mg/(kg min))/(microU/ml), lower, upper quartile, 4.03, 6.56); (SI units: 4.25, lower, upper quartile, 3.22, 5.24 (micromol/(kg min))/(pmol/l)). A multiple linear regression of the natural log transformed value of IS on BMI and body muscle mass measured as the appendicular lean soft tissue (expressed as a percentage of body weight) explained 49% of the variance in IS. Independently, body fat percent and muscle (handgrip) strength showed significant bivariate correlations with IS (rho=-0.61, P<0.001; rho=0.32, P=0.027, respectively), although these variables did not enter into the multiple regression.

CONCLUSIONS

BMI and body fat have been shown to be inversely related to IS at higher BMIs. This study indicates that a relative increase in BMI and reduced muscle mass and possibly function are also associated with reduced IS in lean Indian men.

Authors+Show Affiliations

St John's Research Institute, St John's National Academy of Health Sciences, Bangalore, Karnataka, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19471290

Citation

Unni, U S., et al. "Muscle Mass and Functional Correlates of Insulin Sensitivity in Lean Young Indian Men." European Journal of Clinical Nutrition, vol. 63, no. 10, 2009, pp. 1206-12.
Unni US, Ramakrishnan G, Raj T, et al. Muscle mass and functional correlates of insulin sensitivity in lean young Indian men. Eur J Clin Nutr. 2009;63(10):1206-12.
Unni, U. S., Ramakrishnan, G., Raj, T., Kishore, R. P., Thomas, T., Vaz, M., & Kurpad, A. V. (2009). Muscle mass and functional correlates of insulin sensitivity in lean young Indian men. European Journal of Clinical Nutrition, 63(10), 1206-12. https://doi.org/10.1038/ejcn.2009.32
Unni US, et al. Muscle Mass and Functional Correlates of Insulin Sensitivity in Lean Young Indian Men. Eur J Clin Nutr. 2009;63(10):1206-12. PubMed PMID: 19471290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Muscle mass and functional correlates of insulin sensitivity in lean young Indian men. AU - Unni,U S, AU - Ramakrishnan,G, AU - Raj,T, AU - Kishore,R P, AU - Thomas,T, AU - Vaz,M, AU - Kurpad,A V, Y1 - 2009/05/27/ PY - 2009/5/28/entrez PY - 2009/5/28/pubmed PY - 2010/1/5/medline SP - 1206 EP - 12 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 63 IS - 10 N2 - BACKGROUND/OBJECTIVES: There is a high prevalence of diabetes mellitus associated with insulin resistance in Indian adults, probably due to an inappropriately high accumulation of body fat at lower body mass indices (BMIs, kg/m(2)), as well as to a lower skeletal muscle mass. Although skeletal muscle is an important site of glucose disposal, the strength of its association with insulin sensitivity (IS) is unknown in the Indian population. SUBJECTS/METHODS: This was a cross-sectional study performed to assess the association of body fat, muscle and muscle function with IS in 51 young, healthy, nonobese Indian men with BMI ranging from 15 to 25 kg/m(2), using hyperinsulinemic euglycemic clamp method. RESULTS: The median IS was 5.32 (mg/(kg min))/(microU/ml), lower, upper quartile, 4.03, 6.56); (SI units: 4.25, lower, upper quartile, 3.22, 5.24 (micromol/(kg min))/(pmol/l)). A multiple linear regression of the natural log transformed value of IS on BMI and body muscle mass measured as the appendicular lean soft tissue (expressed as a percentage of body weight) explained 49% of the variance in IS. Independently, body fat percent and muscle (handgrip) strength showed significant bivariate correlations with IS (rho=-0.61, P<0.001; rho=0.32, P=0.027, respectively), although these variables did not enter into the multiple regression. CONCLUSIONS: BMI and body fat have been shown to be inversely related to IS at higher BMIs. This study indicates that a relative increase in BMI and reduced muscle mass and possibly function are also associated with reduced IS in lean Indian men. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/19471290/Muscle_mass_and_functional_correlates_of_insulin_sensitivity_in_lean_young_Indian_men_ L2 - https://doi.org/10.1038/ejcn.2009.32 DB - PRIME DP - Unbound Medicine ER -