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Development of novel ibuprofen-loaded solid dispersion with improved bioavailability using aqueous solution.
Arch Pharm Res. 2009 May; 32(5):767-72.AP

Abstract

To develop a novel ibuprofen-loaded solid dispersion with enhanced bioavailability, various ibuprofen-loaded solid dispersions were prepared with water, HPMC and poloxamer. The effect of HPMC and poloxamer on aqueous solubility of ibuprofen was investigated. The dissolution and bioavailability of solid dispersion in rats were then evaluated compared to ibuprofen powder. When the amount of carrier increased with a decreased in HPMC/poloxamer ratio, the aqueous solubility of ibuprofen was elevated. The solid dispersion composed of ibuprofen/HPMC/poloxamer at the weight ratio of 10:3:2 improved the drug solubility approximately 4 fold. It gave significantly higher initial plasma concentration, AUC and Cmax of drug than did ibuprofen powder in rats. The solid dispersion improved the bioavailability of drug about 4-fold compared to ibuprofen powder. Thus, this ibuprofen-loaded solid dispersion with water, HPMC and poloxamer was a more effective oral dosage form for improving the bioavailability of poor water-soluble ibuprofen.

Authors+Show Affiliations

College of Pharmacy, Yeungnam University, Gyongsan, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19471892

Citation

Park, Young-Joon, et al. "Development of Novel Ibuprofen-loaded Solid Dispersion With Improved Bioavailability Using Aqueous Solution." Archives of Pharmacal Research, vol. 32, no. 5, 2009, pp. 767-72.
Park YJ, Kwon R, Quan QZ, et al. Development of novel ibuprofen-loaded solid dispersion with improved bioavailability using aqueous solution. Arch Pharm Res. 2009;32(5):767-72.
Park, Y. J., Kwon, R., Quan, Q. Z., Oh, D. H., Kim, J. O., Hwang, M. R., Koo, Y. B., Woo, J. S., Yong, C. S., & Choi, H. G. (2009). Development of novel ibuprofen-loaded solid dispersion with improved bioavailability using aqueous solution. Archives of Pharmacal Research, 32(5), 767-72. https://doi.org/10.1007/s12272-009-1516-3
Park YJ, et al. Development of Novel Ibuprofen-loaded Solid Dispersion With Improved Bioavailability Using Aqueous Solution. Arch Pharm Res. 2009;32(5):767-72. PubMed PMID: 19471892.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of novel ibuprofen-loaded solid dispersion with improved bioavailability using aqueous solution. AU - Park,Young-Joon, AU - Kwon,Ram, AU - Quan,Qi Zhe, AU - Oh,Dong Hoon, AU - Kim,Jong Oh, AU - Hwang,Ma Ro, AU - Koo,Yoon Bon, AU - Woo,Jong Soo, AU - Yong,Chul Soon, AU - Choi,Han-Gon, Y1 - 2009/05/27/ PY - 2009/03/04/received PY - 2009/04/12/accepted PY - 2009/04/09/revised PY - 2009/5/28/entrez PY - 2009/5/28/pubmed PY - 2009/6/30/medline SP - 767 EP - 72 JF - Archives of pharmacal research JO - Arch Pharm Res VL - 32 IS - 5 N2 - To develop a novel ibuprofen-loaded solid dispersion with enhanced bioavailability, various ibuprofen-loaded solid dispersions were prepared with water, HPMC and poloxamer. The effect of HPMC and poloxamer on aqueous solubility of ibuprofen was investigated. The dissolution and bioavailability of solid dispersion in rats were then evaluated compared to ibuprofen powder. When the amount of carrier increased with a decreased in HPMC/poloxamer ratio, the aqueous solubility of ibuprofen was elevated. The solid dispersion composed of ibuprofen/HPMC/poloxamer at the weight ratio of 10:3:2 improved the drug solubility approximately 4 fold. It gave significantly higher initial plasma concentration, AUC and Cmax of drug than did ibuprofen powder in rats. The solid dispersion improved the bioavailability of drug about 4-fold compared to ibuprofen powder. Thus, this ibuprofen-loaded solid dispersion with water, HPMC and poloxamer was a more effective oral dosage form for improving the bioavailability of poor water-soluble ibuprofen. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/19471892/Development_of_novel_ibuprofen_loaded_solid_dispersion_with_improved_bioavailability_using_aqueous_solution_ L2 - https://dx.doi.org/10.1007/s12272-009-1516-3 DB - PRIME DP - Unbound Medicine ER -