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Acute effects of casein on postprandial lipemia and incretin responses in type 2 diabetic subjects.
Nutr Metab Cardiovasc Dis. 2010 Feb; 20(2):101-9.NM

Abstract

BACKGROUND AND AIMS

Exaggerated and prolonged postprandial lipemia is potentially atherogenic and associated with type 2 diabetes. Limited data exist regarding the influence of dietary protein on postprandial lipemia in type 2 diabetes. We investigated, over 8-h, the acute effects of casein alone or in combination with carbohydrate on postprandial lipid and incretin responses to a fat-rich meal in type 2 diabetes.

METHODS AND RESULTS

Eleven type 2 diabetic subjects ingested four test meals in random order: an energy-free soup plus 80 g of fat (control-meal); control-meal plus 45 g carbohydrates (CHO-meal); control-meal plus 45 g of casein (PRO-meal); and PRO-meal plus 45 g carbohydrates (CHO+PRO-meal). Triglyceride and retinyl palmitate responses were measured in plasma and in a chylomicron-rich and chylomicron-poor fraction. We found no significant differences in triglyceride responses to PRO- and CHO+PRO-meal compared to the control-meal. However, the addition of casein to the CHO-meal reduced the raised triglyceride response in the chylomicron-rich fraction. Retinyl palmitate responses did not differ significantly between meals in the chylomicron-rich fraction, whereas the PRO-meal increased retinyl palmitate in the chylomicron-poor fraction. PRO- and PRO+CHO-meal increased insulin and glucagon compared to the control-meal. PRO+CHO-meal increased the glucose-dependent insulinotropic peptide response while no change in glucagon-like peptide-1 responses was detected.

CONCLUSIONS

The data presented suggest that casein per se did not modulate the postprandial triglyceride response in type 2 diabetes. When added to carbohydrate, casein suppressed the triglyceride response in the chylomicron-rich fraction, increased insulin and glucagon but did not affect the incretin responses.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Sygehus THG, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19473824

Citation

Brader, L, et al. "Acute Effects of Casein On Postprandial Lipemia and Incretin Responses in Type 2 Diabetic Subjects." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 20, no. 2, 2010, pp. 101-9.
Brader L, Holm L, Mortensen L, et al. Acute effects of casein on postprandial lipemia and incretin responses in type 2 diabetic subjects. Nutr Metab Cardiovasc Dis. 2010;20(2):101-9.
Brader, L., Holm, L., Mortensen, L., Thomsen, C., Astrup, A., Holst, J. J., de Vrese, M., Schrezenmeir, J., & Hermansen, K. (2010). Acute effects of casein on postprandial lipemia and incretin responses in type 2 diabetic subjects. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 20(2), 101-9. https://doi.org/10.1016/j.numecd.2009.03.019
Brader L, et al. Acute Effects of Casein On Postprandial Lipemia and Incretin Responses in Type 2 Diabetic Subjects. Nutr Metab Cardiovasc Dis. 2010;20(2):101-9. PubMed PMID: 19473824.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute effects of casein on postprandial lipemia and incretin responses in type 2 diabetic subjects. AU - Brader,L, AU - Holm,L, AU - Mortensen,L, AU - Thomsen,C, AU - Astrup,A, AU - Holst,J J, AU - de Vrese,M, AU - Schrezenmeir,J, AU - Hermansen,K, Y1 - 2009/05/26/ PY - 2008/10/22/received PY - 2008/12/22/revised PY - 2009/03/10/accepted PY - 2009/5/29/entrez PY - 2009/5/29/pubmed PY - 2010/4/30/medline SP - 101 EP - 9 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 20 IS - 2 N2 - BACKGROUND AND AIMS: Exaggerated and prolonged postprandial lipemia is potentially atherogenic and associated with type 2 diabetes. Limited data exist regarding the influence of dietary protein on postprandial lipemia in type 2 diabetes. We investigated, over 8-h, the acute effects of casein alone or in combination with carbohydrate on postprandial lipid and incretin responses to a fat-rich meal in type 2 diabetes. METHODS AND RESULTS: Eleven type 2 diabetic subjects ingested four test meals in random order: an energy-free soup plus 80 g of fat (control-meal); control-meal plus 45 g carbohydrates (CHO-meal); control-meal plus 45 g of casein (PRO-meal); and PRO-meal plus 45 g carbohydrates (CHO+PRO-meal). Triglyceride and retinyl palmitate responses were measured in plasma and in a chylomicron-rich and chylomicron-poor fraction. We found no significant differences in triglyceride responses to PRO- and CHO+PRO-meal compared to the control-meal. However, the addition of casein to the CHO-meal reduced the raised triglyceride response in the chylomicron-rich fraction. Retinyl palmitate responses did not differ significantly between meals in the chylomicron-rich fraction, whereas the PRO-meal increased retinyl palmitate in the chylomicron-poor fraction. PRO- and PRO+CHO-meal increased insulin and glucagon compared to the control-meal. PRO+CHO-meal increased the glucose-dependent insulinotropic peptide response while no change in glucagon-like peptide-1 responses was detected. CONCLUSIONS: The data presented suggest that casein per se did not modulate the postprandial triglyceride response in type 2 diabetes. When added to carbohydrate, casein suppressed the triglyceride response in the chylomicron-rich fraction, increased insulin and glucagon but did not affect the incretin responses. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/19473824/Acute_effects_of_casein_on_postprandial_lipemia_and_incretin_responses_in_type_2_diabetic_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(09)00062-3 DB - PRIME DP - Unbound Medicine ER -