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Overoxidized polypyrrole/multi-walled carbon nanotubes composite modified electrode for in vivo liquid chromatography-electrochemical detection of dopamine.
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jul 01; 877(20-21):1793-8.JC

Abstract

Overoxidized polypyrrole/multi-walled carbon nanotubes (OPPy/MWNTs) modified electrode has been developed for sensitively detecting dopamine (DA). OPPy films developed outside MWNTs might have a porous morphology. Thus, OPPy/MWNTs films developed by this method do not reject ascorbic acid (AA). However, OPPy/MWNTs modified electrode shows largely enhancing oxidative current responses of DA. When combined with liquid chromatography, it not only obtains a low detection limit of 7.5 x 10(-10) mol L(-1) for DA, but also improves the selectivity of DA detection. Mechanisms for the enhancement are also well discussed in this paper. With this approach, microdialysis has been employed for successful assessment of DA in rat striatum.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Wen J
Department of Chemistry, East China Normal University, Shanghai 200062, China.
Zhou L
No affiliation info available
Jin L
No affiliation info available
Cao X
No affiliation info available
Ye BC
No affiliation info available

MeSH

AnimalsBiosensing TechniquesChromatography, LiquidCorpus StriatumDopamineElectrochemical TechniquesElectrodesNanotubes, CarbonOxidation-ReductionPolymersPyrrolesRats

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19473890

Citation

Wen, Jingxia, et al. "Overoxidized Polypyrrole/multi-walled Carbon Nanotubes Composite Modified Electrode for in Vivo Liquid Chromatography-electrochemical Detection of Dopamine." Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, vol. 877, no. 20-21, 2009, pp. 1793-8.
Wen J, Zhou L, Jin L, et al. Overoxidized polypyrrole/multi-walled carbon nanotubes composite modified electrode for in vivo liquid chromatography-electrochemical detection of dopamine. J Chromatogr B Analyt Technol Biomed Life Sci. 2009;877(20-21):1793-8.
Wen, J., Zhou, L., Jin, L., Cao, X., & Ye, B. C. (2009). Overoxidized polypyrrole/multi-walled carbon nanotubes composite modified electrode for in vivo liquid chromatography-electrochemical detection of dopamine. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 877(20-21), 1793-8. https://doi.org/10.1016/j.jchromb.2009.04.014
Wen J, et al. Overoxidized Polypyrrole/multi-walled Carbon Nanotubes Composite Modified Electrode for in Vivo Liquid Chromatography-electrochemical Detection of Dopamine. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jul 1;877(20-21):1793-8. PubMed PMID: 19473890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overoxidized polypyrrole/multi-walled carbon nanotubes composite modified electrode for in vivo liquid chromatography-electrochemical detection of dopamine. AU - Wen,Jingxia, AU - Zhou,Li, AU - Jin,Litong, AU - Cao,Xuni, AU - Ye,Bang-Ce, Y1 - 2009/04/09/ PY - 2008/07/20/received PY - 2009/04/02/revised PY - 2009/04/04/accepted PY - 2009/5/29/entrez PY - 2009/5/29/pubmed PY - 2009/8/18/medline SP - 1793 EP - 8 JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences JO - J Chromatogr B Analyt Technol Biomed Life Sci VL - 877 IS - 20-21 N2 - Overoxidized polypyrrole/multi-walled carbon nanotubes (OPPy/MWNTs) modified electrode has been developed for sensitively detecting dopamine (DA). OPPy films developed outside MWNTs might have a porous morphology. Thus, OPPy/MWNTs films developed by this method do not reject ascorbic acid (AA). However, OPPy/MWNTs modified electrode shows largely enhancing oxidative current responses of DA. When combined with liquid chromatography, it not only obtains a low detection limit of 7.5 x 10(-10) mol L(-1) for DA, but also improves the selectivity of DA detection. Mechanisms for the enhancement are also well discussed in this paper. With this approach, microdialysis has been employed for successful assessment of DA in rat striatum. SN - 1873-376X UR - https://www.unboundmedicine.com/medline/citation/19473890/Overoxidized_polypyrrole/multi_walled_carbon_nanotubes_composite_modified_electrode_for_in_vivo_liquid_chromatography_electrochemical_detection_of_dopamine_ DB - PRIME DP - Unbound Medicine ER -