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Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk.

Abstract

BACKGROUND

Greater fish and omega-3 (n-3) polyunsaturated fatty acid (PUFA) intake may reduce dementia risk; however, previous studies have reported conflicting results, which were largely based on short-term follow-up.

OBJECTIVE

The objective was to study the dietary consumption of fish and omega-3 PUFAs in relation to long-term dementia risk.

DESIGN

We studied 5395 participants aged > or =55 y in the Rotterdam Study who were free of dementia and reported dietary information at baseline. We used age- and sex-adjusted Cox proportional hazard and multivariate-adjusted models to evaluate the relative risk of dementia and Alzheimer disease (AD) across categories of typical fish intake (none, low, and high) and fish type consumed (none, lean, and fatty). We also evaluated dementia and AD risk across tertiles of omega-3 PUFA intake, specifically, total long-chain omega-3 fatty acids: eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA), alpha-linolenic acid, and EPA and DHA individually.

RESULTS

During an average follow-up of 9.6 y, dementia developed in 465 participants (365 with a diagnosis of AD). In multivariate-adjusted models, total fish intake was unrelated to dementia risk (P for trend = 0.7). Compared with participants who typically ate no fish, those with a high fish intake had a similar dementia risk (hazard ratio: 0.95; 95% CI: 0.76, 1.19), as did those who typically ate fatty fish (hazard ratio: 0.98; 95% CI: 0.77, 1.24). Dietary intakes of omega-3 PUFAs were also not associated with dementia risk, and the results were similar when we considered AD specifically.

CONCLUSION

In this Dutch cohort, who had a moderate consumption of fish and omega-3 PUFAs, these dietary factors do not appear to be associated with long-term dementia risk.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands.

    , , , , , ,

    Source

    MeSH

    Aged
    Alzheimer Disease
    Animals
    Cohort Studies
    Dementia
    Diet
    Docosahexaenoic Acids
    Eicosapentaenoic Acid
    Fatty Acids, Omega-3
    Female
    Fishes
    Humans
    Interviews as Topic
    Life Style
    Male
    Meat
    Middle Aged
    Multivariate Analysis
    Netherlands
    Patient Selection
    Proportional Hazards Models
    Risk
    alpha-Linolenic Acid

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19474131

    Citation

    Devore, Elizabeth E., et al. "Dietary Intake of Fish and Omega-3 Fatty Acids in Relation to Long-term Dementia Risk." The American Journal of Clinical Nutrition, vol. 90, no. 1, 2009, pp. 170-6.
    Devore EE, Grodstein F, van Rooij FJ, et al. Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk. Am J Clin Nutr. 2009;90(1):170-6.
    Devore, E. E., Grodstein, F., van Rooij, F. J., Hofman, A., Rosner, B., Stampfer, M. J., ... Breteler, M. M. (2009). Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk. The American Journal of Clinical Nutrition, 90(1), pp. 170-6. doi:10.3945/ajcn.2008.27037.
    Devore EE, et al. Dietary Intake of Fish and Omega-3 Fatty Acids in Relation to Long-term Dementia Risk. Am J Clin Nutr. 2009;90(1):170-6. PubMed PMID: 19474131.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk. AU - Devore,Elizabeth E, AU - Grodstein,Francine, AU - van Rooij,Frank J A, AU - Hofman,Albert, AU - Rosner,Bernard, AU - Stampfer,Meir J, AU - Witteman,Jacqueline C M, AU - Breteler,Monique M B, Y1 - 2009/05/27/ PY - 2009/5/29/entrez PY - 2009/5/29/pubmed PY - 2009/7/9/medline SP - 170 EP - 6 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 90 IS - 1 N2 - BACKGROUND: Greater fish and omega-3 (n-3) polyunsaturated fatty acid (PUFA) intake may reduce dementia risk; however, previous studies have reported conflicting results, which were largely based on short-term follow-up. OBJECTIVE: The objective was to study the dietary consumption of fish and omega-3 PUFAs in relation to long-term dementia risk. DESIGN: We studied 5395 participants aged > or =55 y in the Rotterdam Study who were free of dementia and reported dietary information at baseline. We used age- and sex-adjusted Cox proportional hazard and multivariate-adjusted models to evaluate the relative risk of dementia and Alzheimer disease (AD) across categories of typical fish intake (none, low, and high) and fish type consumed (none, lean, and fatty). We also evaluated dementia and AD risk across tertiles of omega-3 PUFA intake, specifically, total long-chain omega-3 fatty acids: eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA), alpha-linolenic acid, and EPA and DHA individually. RESULTS: During an average follow-up of 9.6 y, dementia developed in 465 participants (365 with a diagnosis of AD). In multivariate-adjusted models, total fish intake was unrelated to dementia risk (P for trend = 0.7). Compared with participants who typically ate no fish, those with a high fish intake had a similar dementia risk (hazard ratio: 0.95; 95% CI: 0.76, 1.19), as did those who typically ate fatty fish (hazard ratio: 0.98; 95% CI: 0.77, 1.24). Dietary intakes of omega-3 PUFAs were also not associated with dementia risk, and the results were similar when we considered AD specifically. CONCLUSION: In this Dutch cohort, who had a moderate consumption of fish and omega-3 PUFAs, these dietary factors do not appear to be associated with long-term dementia risk. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19474131/Dietary_intake_of_fish_and_omega_3_fatty_acids_in_relation_to_long_term_dementia_risk_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2008.27037 DB - PRIME DP - Unbound Medicine ER -