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Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk.
Am J Clin Nutr 2009; 90(1):170-6AJ

Abstract

BACKGROUND

Greater fish and omega-3 (n-3) polyunsaturated fatty acid (PUFA) intake may reduce dementia risk; however, previous studies have reported conflicting results, which were largely based on short-term follow-up.

OBJECTIVE

The objective was to study the dietary consumption of fish and omega-3 PUFAs in relation to long-term dementia risk.

DESIGN

We studied 5395 participants aged > or =55 y in the Rotterdam Study who were free of dementia and reported dietary information at baseline. We used age- and sex-adjusted Cox proportional hazard and multivariate-adjusted models to evaluate the relative risk of dementia and Alzheimer disease (AD) across categories of typical fish intake (none, low, and high) and fish type consumed (none, lean, and fatty). We also evaluated dementia and AD risk across tertiles of omega-3 PUFA intake, specifically, total long-chain omega-3 fatty acids: eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA), alpha-linolenic acid, and EPA and DHA individually.

RESULTS

During an average follow-up of 9.6 y, dementia developed in 465 participants (365 with a diagnosis of AD). In multivariate-adjusted models, total fish intake was unrelated to dementia risk (P for trend = 0.7). Compared with participants who typically ate no fish, those with a high fish intake had a similar dementia risk (hazard ratio: 0.95; 95% CI: 0.76, 1.19), as did those who typically ate fatty fish (hazard ratio: 0.98; 95% CI: 0.77, 1.24). Dietary intakes of omega-3 PUFAs were also not associated with dementia risk, and the results were similar when we considered AD specifically.

CONCLUSION

In this Dutch cohort, who had a moderate consumption of fish and omega-3 PUFAs, these dietary factors do not appear to be associated with long-term dementia risk.

Authors+Show Affiliations

Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19474131

Citation

Devore, Elizabeth E., et al. "Dietary Intake of Fish and Omega-3 Fatty Acids in Relation to Long-term Dementia Risk." The American Journal of Clinical Nutrition, vol. 90, no. 1, 2009, pp. 170-6.
Devore EE, Grodstein F, van Rooij FJ, et al. Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk. Am J Clin Nutr. 2009;90(1):170-6.
Devore, E. E., Grodstein, F., van Rooij, F. J., Hofman, A., Rosner, B., Stampfer, M. J., ... Breteler, M. M. (2009). Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk. The American Journal of Clinical Nutrition, 90(1), pp. 170-6. doi:10.3945/ajcn.2008.27037.
Devore EE, et al. Dietary Intake of Fish and Omega-3 Fatty Acids in Relation to Long-term Dementia Risk. Am J Clin Nutr. 2009;90(1):170-6. PubMed PMID: 19474131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk. AU - Devore,Elizabeth E, AU - Grodstein,Francine, AU - van Rooij,Frank J A, AU - Hofman,Albert, AU - Rosner,Bernard, AU - Stampfer,Meir J, AU - Witteman,Jacqueline C M, AU - Breteler,Monique M B, Y1 - 2009/05/27/ PY - 2009/5/29/entrez PY - 2009/5/29/pubmed PY - 2009/7/9/medline SP - 170 EP - 6 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 90 IS - 1 N2 - BACKGROUND: Greater fish and omega-3 (n-3) polyunsaturated fatty acid (PUFA) intake may reduce dementia risk; however, previous studies have reported conflicting results, which were largely based on short-term follow-up. OBJECTIVE: The objective was to study the dietary consumption of fish and omega-3 PUFAs in relation to long-term dementia risk. DESIGN: We studied 5395 participants aged > or =55 y in the Rotterdam Study who were free of dementia and reported dietary information at baseline. We used age- and sex-adjusted Cox proportional hazard and multivariate-adjusted models to evaluate the relative risk of dementia and Alzheimer disease (AD) across categories of typical fish intake (none, low, and high) and fish type consumed (none, lean, and fatty). We also evaluated dementia and AD risk across tertiles of omega-3 PUFA intake, specifically, total long-chain omega-3 fatty acids: eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA), alpha-linolenic acid, and EPA and DHA individually. RESULTS: During an average follow-up of 9.6 y, dementia developed in 465 participants (365 with a diagnosis of AD). In multivariate-adjusted models, total fish intake was unrelated to dementia risk (P for trend = 0.7). Compared with participants who typically ate no fish, those with a high fish intake had a similar dementia risk (hazard ratio: 0.95; 95% CI: 0.76, 1.19), as did those who typically ate fatty fish (hazard ratio: 0.98; 95% CI: 0.77, 1.24). Dietary intakes of omega-3 PUFAs were also not associated with dementia risk, and the results were similar when we considered AD specifically. CONCLUSION: In this Dutch cohort, who had a moderate consumption of fish and omega-3 PUFAs, these dietary factors do not appear to be associated with long-term dementia risk. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19474131/Dietary_intake_of_fish_and_omega_3_fatty_acids_in_relation_to_long_term_dementia_risk_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2008.27037 DB - PRIME DP - Unbound Medicine ER -