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Phenolic compounds from Hypericum calycinum and their antioxidant activity.
Nat Prod Commun. 2009 Apr; 4(4):531-4.NP

Abstract

From the MeOH extract of Hypericum calycinum, two caffeoylquinic acid derivatives, butyl chlorogenate (1), and chlorogenic acid (2), seven flavonoids, quercetin (3), quercitrin (4), hyperoside (5), isoquercitrin (6), miquelianin (7), rutin (8) and I3,II8-biapigenin (9) and two flavanols, (+)-catechin (10) and (-)-epicatechin (11) were isolated. Identification of the isolates was carried out by spectroscopic analysis including 1D and 2D NMR experiments as well as mass spectrometry. Free radical scavenging activities of the isolated compounds were determined in in-vitro 1,1-diphenyl-2-picrylhydrazyl (DPPH) and nitric oxide (NO) scavenging models. The compounds showed strong DPPH and moderate NO scavenging activities in a concentration dependent manner. (+)-Catechin and (-)-epicatechin were found to be the most active compounds with IC50 values of 4.16 and 4.67 microM for DPPH and 190 and 170 microM for NO scavenging activities, respectively.

Authors+Show Affiliations

Department of Pharmacognosy, Faculty of Pharmacy, Yeditepe University, TR-34755, Kayişdaği, Istanbul, Turkey. hasankbekmez@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19476000

Citation

Kirmizibekmez, Hasan, et al. "Phenolic Compounds From Hypericum Calycinum and Their Antioxidant Activity." Natural Product Communications, vol. 4, no. 4, 2009, pp. 531-4.
Kirmizibekmez H, Bassarello C, Piacente S, et al. Phenolic compounds from Hypericum calycinum and their antioxidant activity. Nat Prod Commun. 2009;4(4):531-4.
Kirmizibekmez, H., Bassarello, C., Piacente, S., Celep, E., Atay, I., Mercanoğlu, G., & Yeşilada, E. (2009). Phenolic compounds from Hypericum calycinum and their antioxidant activity. Natural Product Communications, 4(4), 531-4.
Kirmizibekmez H, et al. Phenolic Compounds From Hypericum Calycinum and Their Antioxidant Activity. Nat Prod Commun. 2009;4(4):531-4. PubMed PMID: 19476000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phenolic compounds from Hypericum calycinum and their antioxidant activity. AU - Kirmizibekmez,Hasan, AU - Bassarello,Carla, AU - Piacente,Sonia, AU - Celep,Engin, AU - Atay,Irem, AU - Mercanoğlu,Güldem, AU - Yeşilada,Erdem, PY - 2009/5/30/entrez PY - 2009/5/30/pubmed PY - 2009/7/21/medline SP - 531 EP - 4 JF - Natural product communications JO - Nat Prod Commun VL - 4 IS - 4 N2 - From the MeOH extract of Hypericum calycinum, two caffeoylquinic acid derivatives, butyl chlorogenate (1), and chlorogenic acid (2), seven flavonoids, quercetin (3), quercitrin (4), hyperoside (5), isoquercitrin (6), miquelianin (7), rutin (8) and I3,II8-biapigenin (9) and two flavanols, (+)-catechin (10) and (-)-epicatechin (11) were isolated. Identification of the isolates was carried out by spectroscopic analysis including 1D and 2D NMR experiments as well as mass spectrometry. Free radical scavenging activities of the isolated compounds were determined in in-vitro 1,1-diphenyl-2-picrylhydrazyl (DPPH) and nitric oxide (NO) scavenging models. The compounds showed strong DPPH and moderate NO scavenging activities in a concentration dependent manner. (+)-Catechin and (-)-epicatechin were found to be the most active compounds with IC50 values of 4.16 and 4.67 microM for DPPH and 190 and 170 microM for NO scavenging activities, respectively. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/19476000/Phenolic_compounds_from_Hypericum_calycinum_and_their_antioxidant_activity_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -