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Anti-inflammatory potential and fatty acid content of lipophilic leaf extracts of four Staphylea L. species.
Nat Prod Commun. 2009 Apr; 4(4):543-6.NP

Abstract

Staphylea preparations are used in TCM and have been used by native Americans for a number of indications, such as rheumatism. Based on this knowledge, the anti-inflammatory activity of light petroleum extracts of leaves of Staphylea colchica Stev., S. elegans Zab., S. holocarpa Hemsl. and S. pinnata L. has been determined using in vitro assays for inhibition of cyclooxygenase (COX-1 and COX-2) and leukotriene B4 (LTB4) formation by lipoxygenase (5-LOX). All extracts inhibited COX-1 and COX-2, with S. holocarpa and S. elegans performing best. Inhibition of LTB4 formation was less pronounced. As unsaturated fatty acids are known to inhibit arachidonic acid metabolism in vitro, the fatty acid content was determined of the active extracts and set in correlation with their activity. Unsaturated fatty acids were found to contribute to the observed COX-2 and LTB4 formation inhibitory activity to a different extent.

Authors+Show Affiliations

Lacikova L
Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, 832 32 Bratislava, Slovakia. lacikova@fpharm.uniba.sk
Pferschy-Wenzig EM
No affiliation info available
Masterova I
No affiliation info available
Grancai D
No affiliation info available
Bauer R
No affiliation info available

MeSH

Anti-Inflammatory AgentsCells, CulturedCyclooxygenase 1Cyclooxygenase InhibitorsFatty AcidsHumansLeukotriene B4Lipoxygenase InhibitorsMagnoliopsidaPlant ExtractsPlant Leaves

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19476002

Citation

Lacikova, Lubica, et al. "Anti-inflammatory Potential and Fatty Acid Content of Lipophilic Leaf Extracts of Four Staphylea L. Species." Natural Product Communications, vol. 4, no. 4, 2009, pp. 543-6.
Lacikova L, Pferschy-Wenzig EM, Masterova I, et al. Anti-inflammatory potential and fatty acid content of lipophilic leaf extracts of four Staphylea L. species. Nat Prod Commun. 2009;4(4):543-6.
Lacikova, L., Pferschy-Wenzig, E. M., Masterova, I., Grancai, D., & Bauer, R. (2009). Anti-inflammatory potential and fatty acid content of lipophilic leaf extracts of four Staphylea L. species. Natural Product Communications, 4(4), 543-6.
Lacikova L, et al. Anti-inflammatory Potential and Fatty Acid Content of Lipophilic Leaf Extracts of Four Staphylea L. Species. Nat Prod Commun. 2009;4(4):543-6. PubMed PMID: 19476002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory potential and fatty acid content of lipophilic leaf extracts of four Staphylea L. species. AU - Lacikova,Lubica, AU - Pferschy-Wenzig,Eva-Maria, AU - Masterova,Irena, AU - Grancai,Daniel, AU - Bauer,Rudolf, PY - 2009/5/30/entrez PY - 2009/5/30/pubmed PY - 2009/7/21/medline SP - 543 EP - 6 JF - Natural product communications JO - Nat Prod Commun VL - 4 IS - 4 N2 - Staphylea preparations are used in TCM and have been used by native Americans for a number of indications, such as rheumatism. Based on this knowledge, the anti-inflammatory activity of light petroleum extracts of leaves of Staphylea colchica Stev., S. elegans Zab., S. holocarpa Hemsl. and S. pinnata L. has been determined using in vitro assays for inhibition of cyclooxygenase (COX-1 and COX-2) and leukotriene B4 (LTB4) formation by lipoxygenase (5-LOX). All extracts inhibited COX-1 and COX-2, with S. holocarpa and S. elegans performing best. Inhibition of LTB4 formation was less pronounced. As unsaturated fatty acids are known to inhibit arachidonic acid metabolism in vitro, the fatty acid content was determined of the active extracts and set in correlation with their activity. Unsaturated fatty acids were found to contribute to the observed COX-2 and LTB4 formation inhibitory activity to a different extent. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/19476002/Anti_inflammatory_potential_and_fatty_acid_content_of_lipophilic_leaf_extracts_of_four_Staphylea_L__species_ L2 - https://antibodies.cancer.gov/detail/CPTC-PTGS2-1 DB - PRIME DP - Unbound Medicine ER -