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Prevalence and risk factors for non-alcoholic fatty liver disease among adults in an urban Sri Lankan population.
J Gastroenterol Hepatol. 2009 Jul; 24(7):1284-8.JG

Abstract

BACKGROUND AND AIMS

Non-alcoholic fatty liver disease (NAFLD) is an emerging problem in the Asia-Pacific region. However, its prevalence and risk factors in Asian (especially South Asian) communities is poorly studied. In this study, the aim was to determine the community prevalence and risk factors for NAFLD among adults in an urban Sri Lankan population.

METHODS

The study population consisted of 35-64-year-old adults, selected by stratified random sampling. NAFLD was diagnosed on established ultrasound criteria for fatty liver, safe alcohol consumption (< 14 units/week for men, < 7 units/week for females) and absence of hepatitis B and C markers. Blood pressure (BP) and anthropometric measurements were made, and fasting glucose, glycosylated hemoglobin, serum lipids, fasting serum insulin and serum alanine aminotransferase (ALT) were determined.

RESULTS

Of the 2985 study participants, 974 (32.6%) had NAFLD (605 [62.1%] women, mean age 52.8 years [standard deviation, 7.3]). On multivariate analysis, obesity, acanthosis nigricans, insulin resistance, elevated diastolic BP, fasting plasma glucose, plasma triglycerides, and ALT twice the upper limit of the reference range or more were independently associated with NAFLD.

CONCLUSION

The prevalence of NAFLD among adults in this urban Sri Lankan community is high and is strongly associated with constituent features of the metabolic syndrome.

Authors+Show Affiliations

Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19476560

Citation

Dassanayake, Anuradha S., et al. "Prevalence and Risk Factors for Non-alcoholic Fatty Liver Disease Among Adults in an Urban Sri Lankan Population." Journal of Gastroenterology and Hepatology, vol. 24, no. 7, 2009, pp. 1284-8.
Dassanayake AS, Kasturiratne A, Rajindrajith S, et al. Prevalence and risk factors for non-alcoholic fatty liver disease among adults in an urban Sri Lankan population. J Gastroenterol Hepatol. 2009;24(7):1284-8.
Dassanayake, A. S., Kasturiratne, A., Rajindrajith, S., Kalubowila, U., Chakrawarthi, S., De Silva, A. P., Makaya, M., Mizoue, T., Kato, N., Wickremasinghe, A. R., & de Silva, H. J. (2009). Prevalence and risk factors for non-alcoholic fatty liver disease among adults in an urban Sri Lankan population. Journal of Gastroenterology and Hepatology, 24(7), 1284-8. https://doi.org/10.1111/j.1440-1746.2009.05831.x
Dassanayake AS, et al. Prevalence and Risk Factors for Non-alcoholic Fatty Liver Disease Among Adults in an Urban Sri Lankan Population. J Gastroenterol Hepatol. 2009;24(7):1284-8. PubMed PMID: 19476560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and risk factors for non-alcoholic fatty liver disease among adults in an urban Sri Lankan population. AU - Dassanayake,Anuradha S, AU - Kasturiratne,Anuradhani, AU - Rajindrajith,Shaman, AU - Kalubowila,Udaya, AU - Chakrawarthi,Sureka, AU - De Silva,Arjuna P, AU - Makaya,Miyuki, AU - Mizoue,Tetsuya, AU - Kato,Norihiro, AU - Wickremasinghe,A Rajitha, AU - de Silva,H Janaka, Y1 - 2009/05/19/ PY - 2009/5/30/entrez PY - 2009/5/30/pubmed PY - 2009/10/29/medline SP - 1284 EP - 8 JF - Journal of gastroenterology and hepatology JO - J Gastroenterol Hepatol VL - 24 IS - 7 N2 - BACKGROUND AND AIMS: Non-alcoholic fatty liver disease (NAFLD) is an emerging problem in the Asia-Pacific region. However, its prevalence and risk factors in Asian (especially South Asian) communities is poorly studied. In this study, the aim was to determine the community prevalence and risk factors for NAFLD among adults in an urban Sri Lankan population. METHODS: The study population consisted of 35-64-year-old adults, selected by stratified random sampling. NAFLD was diagnosed on established ultrasound criteria for fatty liver, safe alcohol consumption (< 14 units/week for men, < 7 units/week for females) and absence of hepatitis B and C markers. Blood pressure (BP) and anthropometric measurements were made, and fasting glucose, glycosylated hemoglobin, serum lipids, fasting serum insulin and serum alanine aminotransferase (ALT) were determined. RESULTS: Of the 2985 study participants, 974 (32.6%) had NAFLD (605 [62.1%] women, mean age 52.8 years [standard deviation, 7.3]). On multivariate analysis, obesity, acanthosis nigricans, insulin resistance, elevated diastolic BP, fasting plasma glucose, plasma triglycerides, and ALT twice the upper limit of the reference range or more were independently associated with NAFLD. CONCLUSION: The prevalence of NAFLD among adults in this urban Sri Lankan community is high and is strongly associated with constituent features of the metabolic syndrome. SN - 1440-1746 UR - https://www.unboundmedicine.com/medline/citation/19476560/Prevalence_and_risk_factors_for_non_alcoholic_fatty_liver_disease_among_adults_in_an_urban_Sri_Lankan_population_ L2 - https://doi.org/10.1111/j.1440-1746.2009.05831.x DB - PRIME DP - Unbound Medicine ER -