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Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet.

Abstract

BACKGROUND

Oxidative stress has been identified in the peritoneal fluid and peripheral blood of women with endometriosis. However, there is little information on the antioxidant intake for this group of women. The objectives of this work were 1) to compare the antioxidant intake among women with and without endometriosis and 2) to design and apply a high antioxidant diet to evaluate its capacity to reduce oxidative stress markers and improve antioxidant markers in the peripheral blood of women with endometriosis.

METHODS

Women with (WEN, n = 83) and without endometriosis (WWE, n = 80) were interviewed using a Food Frequency Questionnaire to compare their antioxidant intake (of vitamins and minerals). Then, the WEN participated in the application of a control (n = 35) and high antioxidant diet (n = 37) for four months. The high antioxidant diet (HAD) guaranteed the intake of 150% of the suggested daily intake of vitamin A (1050 microg retinol equivalents), 660% of the recommended daily intake (RDI) of vitamin C (500 mg) and 133% of the RDI of vitamin E (20 mg). Oxidative stress and antioxidant markers (vitamins and antioxidant enzymatic activity) were determined in plasma every month.

RESULTS

Comparison of antioxidant intake between WWE and WEN showed a lower intake of vitamins A, C, E, zinc, and copper by WEN (p < 0.05, Mann Whitney Rank test). The selenium intake was not statistically different between groups. During the study, the comparison of the 24-hour recalls between groups showed a higher intake of the three vitamins in the HAD group. An increase in the vitamin concentrations (serum retinol, alpha-tocopherol, leukocyte and plasma ascorbate) and antioxidant enzyme activity (superoxide dismutase and glutathione peroxidase) as well as a decrease in oxidative stress markers (malondialdehyde and lipid hydroperoxides) were observed in the HAD group after two months of intervention. These phenomena were not observed in the control group.

CONCLUSION

WEN had a lower intake of antioxidants in comparison to WWE. Peripheral oxidative stress markers diminished, and antioxidant markers were enhanced, in WEN after the application of the HAD.

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  • Authors+Show Affiliations

    ,

    Departamento de Biología Celular, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City, Mexico. j.mier@servidor.inper.edu.mx

    , , , , ,

    Source

    MeSH

    Adult
    Antioxidants
    Biomarkers
    Endometriosis
    Female
    Follow-Up Studies
    Fruit
    Glutathione Peroxidase
    Humans
    Leukocytes
    Nutrition Assessment
    Oxidative Stress
    Reactive Nitrogen Species
    Reactive Oxygen Species
    Superoxide Dismutase
    Vegetables
    Vitamin A
    alpha-Tocopherol

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19476631

    Citation

    Mier-Cabrera, Jennifer, et al. "Women With Endometriosis Improved Their Peripheral Antioxidant Markers After the Application of a High Antioxidant Diet." Reproductive Biology and Endocrinology : RB&E, vol. 7, 2009, p. 54.
    Mier-Cabrera J, Aburto-Soto T, Burrola-Méndez S, et al. Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet. Reprod Biol Endocrinol. 2009;7:54.
    Mier-Cabrera, J., Aburto-Soto, T., Burrola-Méndez, S., Jiménez-Zamudio, L., Tolentino, M. C., Casanueva, E., & Hernández-Guerrero, C. (2009). Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet. Reproductive Biology and Endocrinology : RB&E, 7, p. 54. doi:10.1186/1477-7827-7-54.
    Mier-Cabrera J, et al. Women With Endometriosis Improved Their Peripheral Antioxidant Markers After the Application of a High Antioxidant Diet. Reprod Biol Endocrinol. 2009 May 28;7:54. PubMed PMID: 19476631.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet. AU - Mier-Cabrera,Jennifer, AU - Aburto-Soto,Tania, AU - Burrola-Méndez,Soraya, AU - Jiménez-Zamudio,Luis, AU - Tolentino,Mari C, AU - Casanueva,Esther, AU - Hernández-Guerrero,César, Y1 - 2009/05/28/ PY - 2009/01/21/received PY - 2009/05/28/accepted PY - 2009/5/30/entrez PY - 2009/5/30/pubmed PY - 2009/8/7/medline SP - 54 EP - 54 JF - Reproductive biology and endocrinology : RB&E JO - Reprod. Biol. Endocrinol. VL - 7 N2 - BACKGROUND: Oxidative stress has been identified in the peritoneal fluid and peripheral blood of women with endometriosis. However, there is little information on the antioxidant intake for this group of women. The objectives of this work were 1) to compare the antioxidant intake among women with and without endometriosis and 2) to design and apply a high antioxidant diet to evaluate its capacity to reduce oxidative stress markers and improve antioxidant markers in the peripheral blood of women with endometriosis. METHODS: Women with (WEN, n = 83) and without endometriosis (WWE, n = 80) were interviewed using a Food Frequency Questionnaire to compare their antioxidant intake (of vitamins and minerals). Then, the WEN participated in the application of a control (n = 35) and high antioxidant diet (n = 37) for four months. The high antioxidant diet (HAD) guaranteed the intake of 150% of the suggested daily intake of vitamin A (1050 microg retinol equivalents), 660% of the recommended daily intake (RDI) of vitamin C (500 mg) and 133% of the RDI of vitamin E (20 mg). Oxidative stress and antioxidant markers (vitamins and antioxidant enzymatic activity) were determined in plasma every month. RESULTS: Comparison of antioxidant intake between WWE and WEN showed a lower intake of vitamins A, C, E, zinc, and copper by WEN (p < 0.05, Mann Whitney Rank test). The selenium intake was not statistically different between groups. During the study, the comparison of the 24-hour recalls between groups showed a higher intake of the three vitamins in the HAD group. An increase in the vitamin concentrations (serum retinol, alpha-tocopherol, leukocyte and plasma ascorbate) and antioxidant enzyme activity (superoxide dismutase and glutathione peroxidase) as well as a decrease in oxidative stress markers (malondialdehyde and lipid hydroperoxides) were observed in the HAD group after two months of intervention. These phenomena were not observed in the control group. CONCLUSION: WEN had a lower intake of antioxidants in comparison to WWE. Peripheral oxidative stress markers diminished, and antioxidant markers were enhanced, in WEN after the application of the HAD. SN - 1477-7827 UR - https://www.unboundmedicine.com/medline/citation/19476631/Women_with_endometriosis_improved_their_peripheral_antioxidant_markers_after_the_application_of_a_high_antioxidant_diet_ L2 - https://rbej.biomedcentral.com/articles/10.1186/1477-7827-7-54 DB - PRIME DP - Unbound Medicine ER -