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Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats.
Metabolism. 2009 Aug; 58(8):1170-7.M

Abstract

Ginseng has been reported to ameliorate hyperglycemia in experimental and clinical studies; however, its mechanism of action remains unclear. In this study, we investigated the metabolic effects and putative molecular mechanisms of Korean red ginseng (KRG, Panax ginseng) in animal models for type 2 diabetes mellitus (T2DM) and peripheral insulin-responsive cell lines. Korean red ginseng was administered orally at a dose of 200 mg/(kg d) to Otsuka Long-Evans Tokushima fatty rats for 40 weeks. Initially, chronic administration of KRG reduced weight gain and visceral fat mass in the early period without altering food intake. The KRG-treated Otsuka Long-Evans Tokushima fatty rats showed improved insulin sensitivity and significantly preserved glucose tolerance compared with untreated control animals up to 50 weeks of age, implying that KRG attenuated the development of overt diabetes. KRG promoted fatty acid oxidation by the activation of adenosine monophosphate-activated protein kinase (AMPK) and phosphorylation of acetyl-coenzyme A carboxylase in skeletal muscle and cultured C2C12 muscle cells. Increased expression of peroxisome proliferator-activated receptor-gamma coactivator-1alpha, nuclear respiratory factor-1, cytochrome c, cytochrome c oxidase-4, and glucose transporter 4 by KRG treatment indicates that activated AMPK also enhanced mitochondrial biogenesis and glucose utilization in skeletal muscle. Although these findings suggest that KRG is likely to have beneficial effects on the amelioration of insulin resistance and the prevention of T2DM through the activation of AMPK, further clinical studies are required to evaluate the use of KRG as a supplementary agent for T2DM.

Authors+Show Affiliations

Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120-752, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19477471

Citation

Lee, Hyun Joo, et al. "Korean Red Ginseng (Panax Ginseng) Improves Insulin Sensitivity and Attenuates the Development of Diabetes in Otsuka Long-Evans Tokushima Fatty Rats." Metabolism: Clinical and Experimental, vol. 58, no. 8, 2009, pp. 1170-7.
Lee HJ, Lee YH, Park SK, et al. Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats. Metab Clin Exp. 2009;58(8):1170-7.
Lee, H. J., Lee, Y. H., Park, S. K., Kang, E. S., Kim, H. J., Lee, Y. C., Choi, C. S., Park, S. E., Ahn, C. W., Cha, B. S., Lee, K. W., Kim, K. S., Lim, S. K., & Lee, H. C. (2009). Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats. Metabolism: Clinical and Experimental, 58(8), 1170-7. https://doi.org/10.1016/j.metabol.2009.03.015
Lee HJ, et al. Korean Red Ginseng (Panax Ginseng) Improves Insulin Sensitivity and Attenuates the Development of Diabetes in Otsuka Long-Evans Tokushima Fatty Rats. Metab Clin Exp. 2009;58(8):1170-7. PubMed PMID: 19477471.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats. AU - Lee,Hyun Joo, AU - Lee,Yong-ho, AU - Park,Sang Kyu, AU - Kang,Eun Seok, AU - Kim,Hyo-Jeong, AU - Lee,Young Chul, AU - Choi,Cheol Soo, AU - Park,Se Eun, AU - Ahn,Chul Woo, AU - Cha,Bong Soo, AU - Lee,Kwan Woo, AU - Kim,Kyung-Sup, AU - Lim,Sung Kil, AU - Lee,Hyun Chul, Y1 - 2009/06/18/ PY - 2008/07/31/received PY - 2009/03/04/accepted PY - 2009/5/30/entrez PY - 2009/5/30/pubmed PY - 2009/8/12/medline SP - 1170 EP - 7 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 58 IS - 8 N2 - Ginseng has been reported to ameliorate hyperglycemia in experimental and clinical studies; however, its mechanism of action remains unclear. In this study, we investigated the metabolic effects and putative molecular mechanisms of Korean red ginseng (KRG, Panax ginseng) in animal models for type 2 diabetes mellitus (T2DM) and peripheral insulin-responsive cell lines. Korean red ginseng was administered orally at a dose of 200 mg/(kg d) to Otsuka Long-Evans Tokushima fatty rats for 40 weeks. Initially, chronic administration of KRG reduced weight gain and visceral fat mass in the early period without altering food intake. The KRG-treated Otsuka Long-Evans Tokushima fatty rats showed improved insulin sensitivity and significantly preserved glucose tolerance compared with untreated control animals up to 50 weeks of age, implying that KRG attenuated the development of overt diabetes. KRG promoted fatty acid oxidation by the activation of adenosine monophosphate-activated protein kinase (AMPK) and phosphorylation of acetyl-coenzyme A carboxylase in skeletal muscle and cultured C2C12 muscle cells. Increased expression of peroxisome proliferator-activated receptor-gamma coactivator-1alpha, nuclear respiratory factor-1, cytochrome c, cytochrome c oxidase-4, and glucose transporter 4 by KRG treatment indicates that activated AMPK also enhanced mitochondrial biogenesis and glucose utilization in skeletal muscle. Although these findings suggest that KRG is likely to have beneficial effects on the amelioration of insulin resistance and the prevention of T2DM through the activation of AMPK, further clinical studies are required to evaluate the use of KRG as a supplementary agent for T2DM. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/19477471/Korean_red_ginseng__Panax_ginseng__improves_insulin_sensitivity_and_attenuates_the_development_of_diabetes_in_Otsuka_Long_Evans_Tokushima_fatty_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(09)00125-5 DB - PRIME DP - Unbound Medicine ER -