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Changes in body mass index are associated with changes in inflammatory and endothelial dysfunction biomarkers in obese prepubertal children after 9 months of body mass index SD score loss.
Metabolism. 2009 Aug; 58(8):1153-60.M

Abstract

The metabolic syndrome is associated with insulin resistance, a systemic low-grade inflammatory state, and endothelial dysfunction. These disorders may arise at a very early age in obese children. The aim of this study was to confirm changes in endothelial dysfunction and inflammatory biomarkers in obese prepubertal children and to evaluate the effect of body mass index (BMI) modification on these biomarkers. Biomarkers for inflammation, endothelial dysfunction, and insulin resistance were measured in obese children (47) and healthy controls (47). Baseline pretreatment levels of insulin (P = .019), homeostasis model assessment of insulin resistance (P = .004), soluble intercellular adhesion molecule (sICAM) (P = .003), and C-reactive protein (CRP) (P < .001) were significantly higher in obese children than in controls. After 9 months of treatment, obese children with lowered BMI SD score (SDS-BMI) displayed a significant decrease in insulin (P = .011), homeostasis model assessment of insulin resistance (P = .012), CRP (P = .006), and interleukin-6 (IL-6) (P = .045) levels compared with obese children with stable SDS-BMI; they also displayed a nonsignificant drop in sICAM levels. Similarly, obese children with lowered SDS-BMI displayed a decrease in CRP (P = .005) and IL-6 (P = .065) compared with baseline levels before treatment. In the total obese group, changes in SDS-BMI correlated positively with changes in CRP (P = .035), IL-6 (P = .027), and sICAM-1 (P = .038) levels. Only SDS-BMI was an independent predictive factor for CRP (P = .031), IL-6 (P = .027), and sICAM-1 (P = .033). Prepubertal obese children displayed alterations indicative of endothelial dysfunction, insulin resistance, and inflammatory state. Lowering of the SDS-BMI after 9 months of treatment was associated with an improvement in these variables compared with those in obese children with stable SDS-BMI status.

Authors+Show Affiliations

Health Center of Pozoblanco, Avda. Doctor Vicente Pérez s/n, 14400 Pozoblanco, Córdoba, Spain. rosariomartos90@yahoo.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19477472

Citation

Martos, Rosario, et al. "Changes in Body Mass Index Are Associated With Changes in Inflammatory and Endothelial Dysfunction Biomarkers in Obese Prepubertal Children After 9 Months of Body Mass Index SD Score Loss." Metabolism: Clinical and Experimental, vol. 58, no. 8, 2009, pp. 1153-60.
Martos R, Valle M, Morales RM, et al. Changes in body mass index are associated with changes in inflammatory and endothelial dysfunction biomarkers in obese prepubertal children after 9 months of body mass index SD score loss. Metab Clin Exp. 2009;58(8):1153-60.
Martos, R., Valle, M., Morales, R. M., Cañete, R., Gascón, F., & Urbano, M. M. (2009). Changes in body mass index are associated with changes in inflammatory and endothelial dysfunction biomarkers in obese prepubertal children after 9 months of body mass index SD score loss. Metabolism: Clinical and Experimental, 58(8), 1153-60. https://doi.org/10.1016/j.metabol.2009.03.017
Martos R, et al. Changes in Body Mass Index Are Associated With Changes in Inflammatory and Endothelial Dysfunction Biomarkers in Obese Prepubertal Children After 9 Months of Body Mass Index SD Score Loss. Metab Clin Exp. 2009;58(8):1153-60. PubMed PMID: 19477472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in body mass index are associated with changes in inflammatory and endothelial dysfunction biomarkers in obese prepubertal children after 9 months of body mass index SD score loss. AU - Martos,Rosario, AU - Valle,Miguel, AU - Morales,Rosario M, AU - Cañete,Ramón, AU - Gascón,Félix, AU - Urbano,Maria M, Y1 - 2009/06/18/ PY - 2008/06/26/received PY - 2009/03/31/accepted PY - 2009/5/30/entrez PY - 2009/5/30/pubmed PY - 2009/8/12/medline SP - 1153 EP - 60 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 58 IS - 8 N2 - The metabolic syndrome is associated with insulin resistance, a systemic low-grade inflammatory state, and endothelial dysfunction. These disorders may arise at a very early age in obese children. The aim of this study was to confirm changes in endothelial dysfunction and inflammatory biomarkers in obese prepubertal children and to evaluate the effect of body mass index (BMI) modification on these biomarkers. Biomarkers for inflammation, endothelial dysfunction, and insulin resistance were measured in obese children (47) and healthy controls (47). Baseline pretreatment levels of insulin (P = .019), homeostasis model assessment of insulin resistance (P = .004), soluble intercellular adhesion molecule (sICAM) (P = .003), and C-reactive protein (CRP) (P < .001) were significantly higher in obese children than in controls. After 9 months of treatment, obese children with lowered BMI SD score (SDS-BMI) displayed a significant decrease in insulin (P = .011), homeostasis model assessment of insulin resistance (P = .012), CRP (P = .006), and interleukin-6 (IL-6) (P = .045) levels compared with obese children with stable SDS-BMI; they also displayed a nonsignificant drop in sICAM levels. Similarly, obese children with lowered SDS-BMI displayed a decrease in CRP (P = .005) and IL-6 (P = .065) compared with baseline levels before treatment. In the total obese group, changes in SDS-BMI correlated positively with changes in CRP (P = .035), IL-6 (P = .027), and sICAM-1 (P = .038) levels. Only SDS-BMI was an independent predictive factor for CRP (P = .031), IL-6 (P = .027), and sICAM-1 (P = .033). Prepubertal obese children displayed alterations indicative of endothelial dysfunction, insulin resistance, and inflammatory state. Lowering of the SDS-BMI after 9 months of treatment was associated with an improvement in these variables compared with those in obese children with stable SDS-BMI status. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/19477472/Changes_in_body_mass_index_are_associated_with_changes_in_inflammatory_and_endothelial_dysfunction_biomarkers_in_obese_prepubertal_children_after_9_months_of_body_mass_index_SD_score_loss_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(09)00123-1 DB - PRIME DP - Unbound Medicine ER -