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Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis: histological diagnostic criteria and scoring systems.
Eur J Gastroenterol Hepatol. 2010 Jun; 22(6):643-50.EJ

Abstract

Nonalcoholic fatty liver disease (NAFLD) is recognized as the most common cause of chronic liver disease in western countries. NAFLD is etiologically associated with systemic and hepatic insulin resistance and is considered by many as the hepatic manifestation of the metabolic syndrome. NAFLD has a wide histological spectrum ranging from 'simple' steatosis to nonalcoholic steatohepatitis (NASH), which may progress to cirrhosis. Hepatocellular carcinoma may occur in NASH-related cirrhosis. The diagnosis of NAFLD/NASH is based on clinico-pathological criteria. Currently available noninvasive tests for the diagnosis of NASH lack specificity and sensitivity, so liver biopsy, despite its limitations, still remains the 'golden standard' for confirming or excluding NASH in a patient with chronically-elevated liver enzymes and image-detected steatosis. This review examines the currently used criteria for the histopathological diagnosis of NAFLD/NASH in adults and children and the relevant histological scoring systems.

Authors+Show Affiliations

Laboratory of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Greece. dtiniak@med.uoa.gr

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19478676

Citation

Tiniakos, Dina G.. "Nonalcoholic Fatty Liver Disease/nonalcoholic Steatohepatitis: Histological Diagnostic Criteria and Scoring Systems." European Journal of Gastroenterology & Hepatology, vol. 22, no. 6, 2010, pp. 643-50.
Tiniakos DG. Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis: histological diagnostic criteria and scoring systems. Eur J Gastroenterol Hepatol. 2010;22(6):643-50.
Tiniakos, D. G. (2010). Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis: histological diagnostic criteria and scoring systems. European Journal of Gastroenterology & Hepatology, 22(6), 643-50. https://doi.org/10.1097/MEG.0b013e32832ca0cb
Tiniakos DG. Nonalcoholic Fatty Liver Disease/nonalcoholic Steatohepatitis: Histological Diagnostic Criteria and Scoring Systems. Eur J Gastroenterol Hepatol. 2010;22(6):643-50. PubMed PMID: 19478676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis: histological diagnostic criteria and scoring systems. A1 - Tiniakos,Dina G, PY - 2009/5/30/entrez PY - 2009/5/30/pubmed PY - 2010/7/30/medline SP - 643 EP - 50 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 22 IS - 6 N2 - Nonalcoholic fatty liver disease (NAFLD) is recognized as the most common cause of chronic liver disease in western countries. NAFLD is etiologically associated with systemic and hepatic insulin resistance and is considered by many as the hepatic manifestation of the metabolic syndrome. NAFLD has a wide histological spectrum ranging from 'simple' steatosis to nonalcoholic steatohepatitis (NASH), which may progress to cirrhosis. Hepatocellular carcinoma may occur in NASH-related cirrhosis. The diagnosis of NAFLD/NASH is based on clinico-pathological criteria. Currently available noninvasive tests for the diagnosis of NASH lack specificity and sensitivity, so liver biopsy, despite its limitations, still remains the 'golden standard' for confirming or excluding NASH in a patient with chronically-elevated liver enzymes and image-detected steatosis. This review examines the currently used criteria for the histopathological diagnosis of NAFLD/NASH in adults and children and the relevant histological scoring systems. SN - 1473-5687 UR - https://www.unboundmedicine.com/medline/citation/19478676/Nonalcoholic_fatty_liver_disease/nonalcoholic_steatohepatitis:_histological_diagnostic_criteria_and_scoring_systems_ L2 - http://dx.doi.org/10.1097/MEG.0b013e32832ca0cb DB - PRIME DP - Unbound Medicine ER -