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Relationships between fibrosis amounts assessed by morphometry and liver stiffness measurements in chronic hepatitis or steatohepatitis.
Eur J Gastroenterol Hepatol. 2009 Nov; 21(11):1261-8.EJ

Abstract

OBJECTIVES

To examine the relationships between fibrosis amounts evaluated by morphometric analysis and liver stiffness measurement (LSM) as well as the influence of steatosis, of activity grade and of the type of chronic liver injury.

METHODS

One hundred and fifty-two consecutive patients were selected from a prospective cohort of patients with concurrent liver biopsy and LSM on the basis of a more than 25 mm long liver biopsy. Morphometric quantification of collagen deposition was expressed as fibrosis area fraction (FAF). Steatosis, activity grade, and predominant type of liver injury (chronic hepatitis or steatohepatitis) were assessed.

RESULTS

In the whole population (chronic viral hepatitis n = 96, alcoholic or nonalcoholic steatohepatitis n = 56), FAF was significantly correlated to LSM (rho = 0.6, P<0.0001). Steatosis independently influenced LSM in patients without cirrhosis, but not activity grade. In the absence of cirrhosis, LSM and FAF were correlated in patients with chronic hepatitis (rho = 0.49, P<0.0001) but not in those with steatohepatitis (rho = 0.22, P = 0.16). In cirrhotic patients, LSM was correlated with fibrosis amount. (rho = 0.43, P = 0.006). The area under the receiver operating characteristics curve of LSM was 0.75 for separating no or minor fibrosis from significant fibrosis and 0.9 for the diagnosis of cirrhosis.

CONCLUSION

LSM was significantly correlated with collagen deposition. However, the relationships between LSM and fibrosis amount seems to differ according to steatosis and to the pattern of liver fibrosis below the cirrhotic stage. Its performances are fair for segregating patients with no or minor fibrosis from those with significant fibrosis and high for the diagnosis of cirrhosis.

Authors+Show Affiliations

Department of Pathology, CHU Jean Verdier Hospital, AP-HP, Av du 14 juillet, Bondy, France. marianne.ziol@jvr.aphp.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19478678

Citation

Ziol, Marianne, et al. "Relationships Between Fibrosis Amounts Assessed By Morphometry and Liver Stiffness Measurements in Chronic Hepatitis or Steatohepatitis." European Journal of Gastroenterology & Hepatology, vol. 21, no. 11, 2009, pp. 1261-8.
Ziol M, Kettaneh A, Ganne-Carrié N, et al. Relationships between fibrosis amounts assessed by morphometry and liver stiffness measurements in chronic hepatitis or steatohepatitis. Eur J Gastroenterol Hepatol. 2009;21(11):1261-8.
Ziol, M., Kettaneh, A., Ganne-Carrié, N., Barget, N., Tengher-Barna, I., & Beaugrand, M. (2009). Relationships between fibrosis amounts assessed by morphometry and liver stiffness measurements in chronic hepatitis or steatohepatitis. European Journal of Gastroenterology & Hepatology, 21(11), 1261-8. https://doi.org/10.1097/MEG.0b013e32832a20f5
Ziol M, et al. Relationships Between Fibrosis Amounts Assessed By Morphometry and Liver Stiffness Measurements in Chronic Hepatitis or Steatohepatitis. Eur J Gastroenterol Hepatol. 2009;21(11):1261-8. PubMed PMID: 19478678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships between fibrosis amounts assessed by morphometry and liver stiffness measurements in chronic hepatitis or steatohepatitis. AU - Ziol,Marianne, AU - Kettaneh,Adrien, AU - Ganne-Carrié,Nathalie, AU - Barget,Nathalie, AU - Tengher-Barna,Iulia, AU - Beaugrand,Michel, PY - 2009/5/30/entrez PY - 2009/5/30/pubmed PY - 2010/12/14/medline SP - 1261 EP - 8 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 21 IS - 11 N2 - OBJECTIVES: To examine the relationships between fibrosis amounts evaluated by morphometric analysis and liver stiffness measurement (LSM) as well as the influence of steatosis, of activity grade and of the type of chronic liver injury. METHODS: One hundred and fifty-two consecutive patients were selected from a prospective cohort of patients with concurrent liver biopsy and LSM on the basis of a more than 25 mm long liver biopsy. Morphometric quantification of collagen deposition was expressed as fibrosis area fraction (FAF). Steatosis, activity grade, and predominant type of liver injury (chronic hepatitis or steatohepatitis) were assessed. RESULTS: In the whole population (chronic viral hepatitis n = 96, alcoholic or nonalcoholic steatohepatitis n = 56), FAF was significantly correlated to LSM (rho = 0.6, P<0.0001). Steatosis independently influenced LSM in patients without cirrhosis, but not activity grade. In the absence of cirrhosis, LSM and FAF were correlated in patients with chronic hepatitis (rho = 0.49, P<0.0001) but not in those with steatohepatitis (rho = 0.22, P = 0.16). In cirrhotic patients, LSM was correlated with fibrosis amount. (rho = 0.43, P = 0.006). The area under the receiver operating characteristics curve of LSM was 0.75 for separating no or minor fibrosis from significant fibrosis and 0.9 for the diagnosis of cirrhosis. CONCLUSION: LSM was significantly correlated with collagen deposition. However, the relationships between LSM and fibrosis amount seems to differ according to steatosis and to the pattern of liver fibrosis below the cirrhotic stage. Its performances are fair for segregating patients with no or minor fibrosis from those with significant fibrosis and high for the diagnosis of cirrhosis. SN - 1473-5687 UR - https://www.unboundmedicine.com/medline/citation/19478678/Relationships_between_fibrosis_amounts_assessed_by_morphometry_and_liver_stiffness_measurements_in_chronic_hepatitis_or_steatohepatitis_ L2 - http://dx.doi.org/10.1097/MEG.0b013e32832a20f5 DB - PRIME DP - Unbound Medicine ER -