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Long-term traffic-related exposures and asthma onset in schoolchildren in oslo, norway.
Environ Health Perspect. 2009 May; 117(5):839-44.EH

Abstract

BACKGROUND

Whether there is a causal relation between long-term exposure to traffic and asthma development is so far not clear. This may be explained by inaccurate exposure assessment.

OBJECTIVE

We investigated the associations of long-term traffic-related exposures with asthma onset assessed retrospectively and respiratory symptoms in 9- to 10-year-old children.

METHODS

We collected information on respiratory outcomes and potential confounding variables by parental questionnaire in 2,871 children in Oslo. Nitrogen dioxide exposure was assessed by the EPISODE dispersion model and assigned at updated individual addresses during lifetime. Distance to major road was assigned at birth address and address by date of questionnaire. Cox proportional hazard regression and logistic regression were used.

RESULTS

We did not find positive associations between any long-term traffic-related exposure and onset of doctor-diagnosed asthma. An interquartile range (IQR) increase of NO(2) exposure before asthma onset was associated with an adjusted risk ratio of 0.82 [95% confidence interval (CI), 0.67-1.02]. Handling early asthma cases (children < 4 years of age) with recovery during follow-up as noncases gave a less negative association. The associations for late asthma onset (>/= 4 years of age) were positive but not statistically significant. For current symptoms, an IQR increase of previous year's NO(2) exposure was associated with adjusted odds ratios of 1.01 (95% CI, 0.83-1.23) for wheeze, 1.10 (95% CI, 0.79-1.51) for severe wheeze, and 1.01 (95% CI, 0.84-1.21) for dry cough.

CONCLUSIONS

We were not able to find positive associations of long-term traffic-related exposures with asthma onset or with current respiratory symptoms in 9- to 10-year-old children in Oslo.

Authors+Show Affiliations

Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway. bente.oftedal@fhi.noNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19478970

Citation

Oftedal, Bente, et al. "Long-term Traffic-related Exposures and Asthma Onset in Schoolchildren in Oslo, Norway." Environmental Health Perspectives, vol. 117, no. 5, 2009, pp. 839-44.
Oftedal B, Nystad W, Brunekreef B, et al. Long-term traffic-related exposures and asthma onset in schoolchildren in oslo, norway. Environ Health Perspect. 2009;117(5):839-44.
Oftedal, B., Nystad, W., Brunekreef, B., & Nafstad, P. (2009). Long-term traffic-related exposures and asthma onset in schoolchildren in oslo, norway. Environmental Health Perspectives, 117(5), 839-44. https://doi.org/10.1289/ehp.11491
Oftedal B, et al. Long-term Traffic-related Exposures and Asthma Onset in Schoolchildren in Oslo, Norway. Environ Health Perspect. 2009;117(5):839-44. PubMed PMID: 19478970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term traffic-related exposures and asthma onset in schoolchildren in oslo, norway. AU - Oftedal,Bente, AU - Nystad,Wenche, AU - Brunekreef,Bert, AU - Nafstad,Per, Y1 - 2009/01/30/ PY - 2008/03/19/received PY - 2009/01/30/accepted PY - 2009/5/30/entrez PY - 2009/5/30/pubmed PY - 2009/9/10/medline KW - NO2 KW - asthma KW - children KW - long-term exposure KW - nitrogen dioxide KW - respiratory symptoms KW - traffic SP - 839 EP - 44 JF - Environmental health perspectives JO - Environ Health Perspect VL - 117 IS - 5 N2 - BACKGROUND: Whether there is a causal relation between long-term exposure to traffic and asthma development is so far not clear. This may be explained by inaccurate exposure assessment. OBJECTIVE: We investigated the associations of long-term traffic-related exposures with asthma onset assessed retrospectively and respiratory symptoms in 9- to 10-year-old children. METHODS: We collected information on respiratory outcomes and potential confounding variables by parental questionnaire in 2,871 children in Oslo. Nitrogen dioxide exposure was assessed by the EPISODE dispersion model and assigned at updated individual addresses during lifetime. Distance to major road was assigned at birth address and address by date of questionnaire. Cox proportional hazard regression and logistic regression were used. RESULTS: We did not find positive associations between any long-term traffic-related exposure and onset of doctor-diagnosed asthma. An interquartile range (IQR) increase of NO(2) exposure before asthma onset was associated with an adjusted risk ratio of 0.82 [95% confidence interval (CI), 0.67-1.02]. Handling early asthma cases (children < 4 years of age) with recovery during follow-up as noncases gave a less negative association. The associations for late asthma onset (>/= 4 years of age) were positive but not statistically significant. For current symptoms, an IQR increase of previous year's NO(2) exposure was associated with adjusted odds ratios of 1.01 (95% CI, 0.83-1.23) for wheeze, 1.10 (95% CI, 0.79-1.51) for severe wheeze, and 1.01 (95% CI, 0.84-1.21) for dry cough. CONCLUSIONS: We were not able to find positive associations of long-term traffic-related exposures with asthma onset or with current respiratory symptoms in 9- to 10-year-old children in Oslo. SN - 1552-9924 UR - https://www.unboundmedicine.com/medline/citation/19478970/Long_term_traffic_related_exposures_and_asthma_onset_in_schoolchildren_in_oslo_norway_ L2 - https://ehp.niehs.nih.gov/doi/10.1289/ehp.11491?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -