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Does a single session of theta-burst transcranial magnetic stimulation of inferior temporal cortex affect tinnitus perception?
BMC Neurosci. 2009 May 29; 10:54.BN

Abstract

BACKGROUND

Cortical excitability changes as well as imbalances in excitatory and inhibitory circuits play a distinct pathophysiological role in chronic tinnitus. Repetitive transcranial magnetic stimulation (rTMS) over the temporoparietal cortex was recently introduced to modulate tinnitus perception. In the current study, the effect of theta-burst stimulation (TBS), a novel rTMS paradigm was investigated in chronic tinnitus. Twenty patients with chronic tinnitus completed the study. Tinnitus severity and loudness were monitored using a tinnitus questionnaire (TQ) and a visual analogue scale (VAS) before each session. Patients received 600 pulses of continuous TBS (cTBS), intermittent TBS (iTBS) and intermediate TBS (imTBS) over left inferior temporal cortex with an intensity of 80% of the individual active or resting motor threshold. Changes in subjective tinnitus perception were measured with a numerical rating scale (NRS).

RESULTS

TBS applied to inferior temporal cortex appeared to be safe. Although half of the patients reported a slight attenuation of tinnitus perception, group analysis resulted in no significant difference when comparing the three specific types of TBS. Converting the NRS into the VAS allowed us to compare the time-course of aftereffects. Only cTBS resulted in a significant short-lasting improvement of the symptoms. In addition there was no significant difference when comparing the responder and non-responder groups regarding their anamnestic and audiological data. The TQ score correlated significantly with the VAS, lower loudness indicating less tinnitus distress.

CONCLUSION

TBS does not offer a promising outcome for patients with tinnitus in the presented study.

Authors+Show Affiliations

Department of Clinical Neurophysiology Georg-August University, Göttingen, Germany. csaba.poreisz@med.uni-goettingen.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19480651

Citation

Poreisz, Csaba, et al. "Does a Single Session of Theta-burst Transcranial Magnetic Stimulation of Inferior Temporal Cortex Affect Tinnitus Perception?" BMC Neuroscience, vol. 10, 2009, p. 54.
Poreisz C, Paulus W, Moser T, et al. Does a single session of theta-burst transcranial magnetic stimulation of inferior temporal cortex affect tinnitus perception? BMC Neurosci. 2009;10:54.
Poreisz, C., Paulus, W., Moser, T., & Lang, N. (2009). Does a single session of theta-burst transcranial magnetic stimulation of inferior temporal cortex affect tinnitus perception? BMC Neuroscience, 10, 54. https://doi.org/10.1186/1471-2202-10-54
Poreisz C, et al. Does a Single Session of Theta-burst Transcranial Magnetic Stimulation of Inferior Temporal Cortex Affect Tinnitus Perception. BMC Neurosci. 2009 May 29;10:54. PubMed PMID: 19480651.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does a single session of theta-burst transcranial magnetic stimulation of inferior temporal cortex affect tinnitus perception? AU - Poreisz,Csaba, AU - Paulus,Walter, AU - Moser,Tobias, AU - Lang,Nicolas, Y1 - 2009/05/29/ PY - 2008/09/17/received PY - 2009/05/29/accepted PY - 2009/6/2/entrez PY - 2009/6/2/pubmed PY - 2009/8/18/medline SP - 54 EP - 54 JF - BMC neuroscience JO - BMC Neurosci VL - 10 N2 - BACKGROUND: Cortical excitability changes as well as imbalances in excitatory and inhibitory circuits play a distinct pathophysiological role in chronic tinnitus. Repetitive transcranial magnetic stimulation (rTMS) over the temporoparietal cortex was recently introduced to modulate tinnitus perception. In the current study, the effect of theta-burst stimulation (TBS), a novel rTMS paradigm was investigated in chronic tinnitus. Twenty patients with chronic tinnitus completed the study. Tinnitus severity and loudness were monitored using a tinnitus questionnaire (TQ) and a visual analogue scale (VAS) before each session. Patients received 600 pulses of continuous TBS (cTBS), intermittent TBS (iTBS) and intermediate TBS (imTBS) over left inferior temporal cortex with an intensity of 80% of the individual active or resting motor threshold. Changes in subjective tinnitus perception were measured with a numerical rating scale (NRS). RESULTS: TBS applied to inferior temporal cortex appeared to be safe. Although half of the patients reported a slight attenuation of tinnitus perception, group analysis resulted in no significant difference when comparing the three specific types of TBS. Converting the NRS into the VAS allowed us to compare the time-course of aftereffects. Only cTBS resulted in a significant short-lasting improvement of the symptoms. In addition there was no significant difference when comparing the responder and non-responder groups regarding their anamnestic and audiological data. The TQ score correlated significantly with the VAS, lower loudness indicating less tinnitus distress. CONCLUSION: TBS does not offer a promising outcome for patients with tinnitus in the presented study. SN - 1471-2202 UR - https://www.unboundmedicine.com/medline/citation/19480651/Does_a_single_session_of_theta_burst_transcranial_magnetic_stimulation_of_inferior_temporal_cortex_affect_tinnitus_perception DB - PRIME DP - Unbound Medicine ER -