Tags

Type your tag names separated by a space and hit enter

Dietary polyunsaturated fatty acids and adaptation to chronic hypoxia alter acyl composition of serum and heart lipids.
Br J Nutr. 2009 Nov; 102(9):1297-307.BJ

Abstract

The effects of dietary supplementation with fat of different fatty acid profile and chronic intermittent hypoxia (CIH) on the fatty acid composition of serum and heart lipids were analysed. Adult male Wistar rats were fed a standard non-fat diet enriched with 10 % of lard, fish oil (n-3 PUFA) or maize oil (n-6 PUFA) for 10 weeks. After 4 weeks on the diets, each group was divided in two subgroups, either exposed to CIH in a barochamber (7000 m, twenty-five exposures) or kept at normoxia. In normoxic rats, the fish oil diet increased the level of conjugated dienes. The n-6:n-3 PUFA ratio in serum TAG, phospholipids (PL), cholesteryl esters (CE) and heart TAG, PL and diacylglycerols (DAG) followed the ratio in the fed diet (in the sequence maize oil>lard>fish oil). In heart TAG, PL and DAG, 20 : 4n-6 and 18 : 2n-6 were replaced by 22 : 6n-3 in the fish oil group. The main fatty acid in CE was 20 : 4n-6 in the lard and maize oil groups whereas in the fish oil group, half of 20 : 4n-6 was replaced by 20 : 5n-3. CIH further increased 20 : 5n-3 in CE in the fish oil group. CIH decreased the n-6:n-3 PUFA ratio in serum CE, heart TAG, PL and DAG in all dietary groups and stimulated the activity of catalase in the maize and fish oil groups. In conclusion, PUFA diets and CIH, both interventions considered to be cardioprotective, distinctly modified the fatty acid profile in serum and heart lipids with specific effects on conjugated diene production and catalase activity.

Authors+Show Affiliations

Department of Cell Biology, Faculty of Science, Charles University, Prague 2, Czech Republic.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19480730

Citation

Balková, Patricie, et al. "Dietary Polyunsaturated Fatty Acids and Adaptation to Chronic Hypoxia Alter Acyl Composition of Serum and Heart Lipids." The British Journal of Nutrition, vol. 102, no. 9, 2009, pp. 1297-307.
Balková P, Jezková J, Hlavácková M, et al. Dietary polyunsaturated fatty acids and adaptation to chronic hypoxia alter acyl composition of serum and heart lipids. Br J Nutr. 2009;102(9):1297-307.
Balková, P., Jezková, J., Hlavácková, M., Neckár, J., Stanková, B., Kolár, F., Novák, F., & Nováková, O. (2009). Dietary polyunsaturated fatty acids and adaptation to chronic hypoxia alter acyl composition of serum and heart lipids. The British Journal of Nutrition, 102(9), 1297-307. https://doi.org/10.1017/S0007114509389242
Balková P, et al. Dietary Polyunsaturated Fatty Acids and Adaptation to Chronic Hypoxia Alter Acyl Composition of Serum and Heart Lipids. Br J Nutr. 2009;102(9):1297-307. PubMed PMID: 19480730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary polyunsaturated fatty acids and adaptation to chronic hypoxia alter acyl composition of serum and heart lipids. AU - Balková,Patricie, AU - Jezková,Jana, AU - Hlavácková,Markéta, AU - Neckár,Jan, AU - Stanková,Barbora, AU - Kolár,Frantisek, AU - Novák,Frantisek, AU - Nováková,Olga, Y1 - 2009/06/01/ PY - 2009/6/2/entrez PY - 2009/6/2/pubmed PY - 2009/12/22/medline SP - 1297 EP - 307 JF - The British journal of nutrition JO - Br J Nutr VL - 102 IS - 9 N2 - The effects of dietary supplementation with fat of different fatty acid profile and chronic intermittent hypoxia (CIH) on the fatty acid composition of serum and heart lipids were analysed. Adult male Wistar rats were fed a standard non-fat diet enriched with 10 % of lard, fish oil (n-3 PUFA) or maize oil (n-6 PUFA) for 10 weeks. After 4 weeks on the diets, each group was divided in two subgroups, either exposed to CIH in a barochamber (7000 m, twenty-five exposures) or kept at normoxia. In normoxic rats, the fish oil diet increased the level of conjugated dienes. The n-6:n-3 PUFA ratio in serum TAG, phospholipids (PL), cholesteryl esters (CE) and heart TAG, PL and diacylglycerols (DAG) followed the ratio in the fed diet (in the sequence maize oil>lard>fish oil). In heart TAG, PL and DAG, 20 : 4n-6 and 18 : 2n-6 were replaced by 22 : 6n-3 in the fish oil group. The main fatty acid in CE was 20 : 4n-6 in the lard and maize oil groups whereas in the fish oil group, half of 20 : 4n-6 was replaced by 20 : 5n-3. CIH further increased 20 : 5n-3 in CE in the fish oil group. CIH decreased the n-6:n-3 PUFA ratio in serum CE, heart TAG, PL and DAG in all dietary groups and stimulated the activity of catalase in the maize and fish oil groups. In conclusion, PUFA diets and CIH, both interventions considered to be cardioprotective, distinctly modified the fatty acid profile in serum and heart lipids with specific effects on conjugated diene production and catalase activity. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/19480730/Dietary_polyunsaturated_fatty_acids_and_adaptation_to_chronic_hypoxia_alter_acyl_composition_of_serum_and_heart_lipids_ L2 - https://www.cambridge.org/core/product/identifier/S0007114509389242/type/journal_article DB - PRIME DP - Unbound Medicine ER -