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Antibacterial and antifungal activity of Flindersine isolated from the traditional medicinal plant, Toddalia asiatica (L.) Lam.
J Ethnopharmacol. 2009 Jun 25; 123(3):494-8.JE

Abstract

AIM OF THE STUDY

The leaves and root of Toddalia asiatica (L.) Lam. (Rutaceae) are widely used as a folk medicine in India. Hexane, chloroform, ethyl acetate, methanol and water extracts of Toddalia asiatica leaves and isolated compound Flindersine were tested against bacteria and fungi.

MATERIALS AND METHODS

Antibacterial and antifungal activities were tested against bacteria and fungi using disc-diffusion method and minimum inhibitory concentrations (MICs). The compound was confirmed using X-ray crystallography technique.

RESULTS

Antibacterial and antifungal activities were observed in ethyl acetate extract. One active principle Flindersine (2,6-dihydro-2,2-dimethyl-5H-pyrano [3,2-c] quinoline-5-one-9cl) was isolated from the ethyl acetate extract. The MIC values of the compound against bacteria Bacillus subtilis (31.25 microg/ml), Staphylococcus aureus (62.5 microg/ml), Staphylococcus epidermidis (62.5 microg/ml), Enterococcus faecalis (31.25 microg/ml), Pseudomonas aeruginosa (250 microg/ml), Acinetobacter baumannii (125 microg/ml) and fungi Trichophyton rubrum 57 (62.5 microg/ml), Trichophyton mentagrophytes (62.5 microg/ml), Trichophyton simii (62.5 microg/ml), Epidermophyton floccosum (62.5 microg/ml), Magnaporthe grisea (250 microg/ml) and Candida albicans (250 microg/ml) were determined.

CONCLUSIONS

Ethyl acetate extract showed promising antibacterial and antifungal activity and isolated compound Flindersine showed moderate activity against bacteria and fungi.

Authors+Show Affiliations

Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600034, Tamil Nadu, India.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19481384

Citation

Duraipandiyan, V, and S Ignacimuthu. "Antibacterial and Antifungal Activity of Flindersine Isolated From the Traditional Medicinal Plant, Toddalia Asiatica (L.) Lam." Journal of Ethnopharmacology, vol. 123, no. 3, 2009, pp. 494-8.
Duraipandiyan V, Ignacimuthu S. Antibacterial and antifungal activity of Flindersine isolated from the traditional medicinal plant, Toddalia asiatica (L.) Lam. J Ethnopharmacol. 2009;123(3):494-8.
Duraipandiyan, V., & Ignacimuthu, S. (2009). Antibacterial and antifungal activity of Flindersine isolated from the traditional medicinal plant, Toddalia asiatica (L.) Lam. Journal of Ethnopharmacology, 123(3), 494-8. https://doi.org/10.1016/j.jep.2009.02.020
Duraipandiyan V, Ignacimuthu S. Antibacterial and Antifungal Activity of Flindersine Isolated From the Traditional Medicinal Plant, Toddalia Asiatica (L.) Lam. J Ethnopharmacol. 2009 Jun 25;123(3):494-8. PubMed PMID: 19481384.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibacterial and antifungal activity of Flindersine isolated from the traditional medicinal plant, Toddalia asiatica (L.) Lam. AU - Duraipandiyan,V, AU - Ignacimuthu,S, Y1 - 2009/02/25/ PY - 2007/11/18/received PY - 2008/09/08/revised PY - 2009/02/12/accepted PY - 2009/6/2/entrez PY - 2009/6/2/pubmed PY - 2009/10/9/medline SP - 494 EP - 8 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 123 IS - 3 N2 - AIM OF THE STUDY: The leaves and root of Toddalia asiatica (L.) Lam. (Rutaceae) are widely used as a folk medicine in India. Hexane, chloroform, ethyl acetate, methanol and water extracts of Toddalia asiatica leaves and isolated compound Flindersine were tested against bacteria and fungi. MATERIALS AND METHODS: Antibacterial and antifungal activities were tested against bacteria and fungi using disc-diffusion method and minimum inhibitory concentrations (MICs). The compound was confirmed using X-ray crystallography technique. RESULTS: Antibacterial and antifungal activities were observed in ethyl acetate extract. One active principle Flindersine (2,6-dihydro-2,2-dimethyl-5H-pyrano [3,2-c] quinoline-5-one-9cl) was isolated from the ethyl acetate extract. The MIC values of the compound against bacteria Bacillus subtilis (31.25 microg/ml), Staphylococcus aureus (62.5 microg/ml), Staphylococcus epidermidis (62.5 microg/ml), Enterococcus faecalis (31.25 microg/ml), Pseudomonas aeruginosa (250 microg/ml), Acinetobacter baumannii (125 microg/ml) and fungi Trichophyton rubrum 57 (62.5 microg/ml), Trichophyton mentagrophytes (62.5 microg/ml), Trichophyton simii (62.5 microg/ml), Epidermophyton floccosum (62.5 microg/ml), Magnaporthe grisea (250 microg/ml) and Candida albicans (250 microg/ml) were determined. CONCLUSIONS: Ethyl acetate extract showed promising antibacterial and antifungal activity and isolated compound Flindersine showed moderate activity against bacteria and fungi. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/19481384/Antibacterial_and_antifungal_activity_of_Flindersine_isolated_from_the_traditional_medicinal_plant_Toddalia_asiatica__L___Lam_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(09)00095-6 DB - PRIME DP - Unbound Medicine ER -