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Relationship of retinal vascular caliber with optic disc and macular structure.
Am J Ophthalmol. 2009 Sep; 148(3):368-75.AJ

Abstract

PURPOSE

To examine the relationships of retinal vascular caliber with optic disc, macular, and retinal nerve fiber layer (RNFL) characteristics as measured with optical coherence tomography (OCT).

DESIGN

Observational cross-sectional study.

METHODS

This study included a subset of healthy children enrolled in the Singapore Cohort Study of the Risk Factors of Myopia (SCORM). Optic disc, macular, and RNFL morphology were measured with Stratus OCT 3. Digital retinal photography was performed and retinal arteriolar and venular caliber measured using validated imaging software.

RESULTS

One hundred and four children (mean age 11.51 +/- 0.52 years; 50% male) were included. In multivariate analyses, smaller horizontal integrated rim width and rim area were associated with narrower retinal arterioles and venules (all P < .05), and shorter horizontal rim length was associated with narrower venules (P = .04). Optic disc diameter was not associated with arteriolar or venular caliber. Larger vertical cup-to-disc ratios and cup-to-disc-area ratios were associated with narrower venules but not arterioles (P = .01 and P = .003, respectively). A thinner average RNFL measurement was associated with narrower arterioles and venules, and smaller total macular volume was associated with narrower venules.

CONCLUSIONS

Thinner optic disc rims and RNFL measurements were associated with narrower retinal arterioles and venules, and larger cup-to-disc ratios with narrower venules. These findings suggest that retinal vessel caliber varies systematically with morphologic differences in the optic nerve head, retina, and macula.

Authors+Show Affiliations

Singapore National Eye Centre, Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19481730

Citation

Lim, Laurence S., et al. "Relationship of Retinal Vascular Caliber With Optic Disc and Macular Structure." American Journal of Ophthalmology, vol. 148, no. 3, 2009, pp. 368-75.
Lim LS, Saw SM, Cheung N, et al. Relationship of retinal vascular caliber with optic disc and macular structure. Am J Ophthalmol. 2009;148(3):368-75.
Lim, L. S., Saw, S. M., Cheung, N., Mitchell, P., & Wong, T. Y. (2009). Relationship of retinal vascular caliber with optic disc and macular structure. American Journal of Ophthalmology, 148(3), 368-75. https://doi.org/10.1016/j.ajo.2009.04.006
Lim LS, et al. Relationship of Retinal Vascular Caliber With Optic Disc and Macular Structure. Am J Ophthalmol. 2009;148(3):368-75. PubMed PMID: 19481730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of retinal vascular caliber with optic disc and macular structure. AU - Lim,Laurence S, AU - Saw,Seang Mei, AU - Cheung,Ning, AU - Mitchell,Paul, AU - Wong,Tien Y, Y1 - 2009/05/30/ PY - 2009/01/29/received PY - 2009/04/07/revised PY - 2009/04/08/accepted PY - 2009/6/2/entrez PY - 2009/6/2/pubmed PY - 2009/9/3/medline SP - 368 EP - 75 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 148 IS - 3 N2 - PURPOSE: To examine the relationships of retinal vascular caliber with optic disc, macular, and retinal nerve fiber layer (RNFL) characteristics as measured with optical coherence tomography (OCT). DESIGN: Observational cross-sectional study. METHODS: This study included a subset of healthy children enrolled in the Singapore Cohort Study of the Risk Factors of Myopia (SCORM). Optic disc, macular, and RNFL morphology were measured with Stratus OCT 3. Digital retinal photography was performed and retinal arteriolar and venular caliber measured using validated imaging software. RESULTS: One hundred and four children (mean age 11.51 +/- 0.52 years; 50% male) were included. In multivariate analyses, smaller horizontal integrated rim width and rim area were associated with narrower retinal arterioles and venules (all P < .05), and shorter horizontal rim length was associated with narrower venules (P = .04). Optic disc diameter was not associated with arteriolar or venular caliber. Larger vertical cup-to-disc ratios and cup-to-disc-area ratios were associated with narrower venules but not arterioles (P = .01 and P = .003, respectively). A thinner average RNFL measurement was associated with narrower arterioles and venules, and smaller total macular volume was associated with narrower venules. CONCLUSIONS: Thinner optic disc rims and RNFL measurements were associated with narrower retinal arterioles and venules, and larger cup-to-disc ratios with narrower venules. These findings suggest that retinal vessel caliber varies systematically with morphologic differences in the optic nerve head, retina, and macula. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/19481730/Relationship_of_retinal_vascular_caliber_with_optic_disc_and_macular_structure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(09)00280-3 DB - PRIME DP - Unbound Medicine ER -