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Insights into endometriosis-associated endometrial dysfunctions: a review.
Front Biosci (Elite Ed). 2009 Jun 01; 1:415-28.FB

Abstract

Endometriosis is defined as the presence of ectopic endometrial-like tissue outside the uterus cavity. This disease, afflicting women during their reproductive age, is mainly associated with pelvic pain and infertility. Sampson's theory which supports the ability of endometrial fragments from retrograde menstruations to slough through fallopian tubes and reach peritoneal environment has been recognized as the most plausible explanation for endometriosis during many years. However, further studies provided evidence that fundamental abnormal changes may occur within the eutopic endometrium of women with endometriosis compared to that of women without endometriosis. These dysfunctions included genetic predisposition, genes aberrantly expressed such as matrix metalloproteinases, Hox genes, integrins, anti-apoptotic genes Bcl-2, but also steroid hormones, immuno-inflammatory factors and angiogenesis. This review aims at summarizing and emphasizing a non exhaustive panel of biochemical and molecular factors abnormally expressed in the eutopic endometrium and related to the pathogenesis of endometriosis.

Authors+Show Affiliations

Centre de Recherche, Hopital Saint-Francois d'Assise, Centre Hospitalier Universitaire de Quebec (CHUQ), Universite Laval, 10, rue de l'Espinay, local D0-711, Quebec, G1L 3L5 Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19482656

Citation

Bondza, Patrick Kibangou, et al. "Insights Into Endometriosis-associated Endometrial Dysfunctions: a Review." Frontiers in Bioscience (Elite Edition), vol. 1, 2009, pp. 415-28.
Bondza PK, Maheux R, Akoum A. Insights into endometriosis-associated endometrial dysfunctions: a review. Front Biosci (Elite Ed). 2009;1:415-28.
Bondza, P. K., Maheux, R., & Akoum, A. (2009). Insights into endometriosis-associated endometrial dysfunctions: a review. Frontiers in Bioscience (Elite Edition), 1, 415-28.
Bondza PK, Maheux R, Akoum A. Insights Into Endometriosis-associated Endometrial Dysfunctions: a Review. Front Biosci (Elite Ed). 2009 Jun 1;1:415-28. PubMed PMID: 19482656.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insights into endometriosis-associated endometrial dysfunctions: a review. AU - Bondza,Patrick Kibangou, AU - Maheux,Rodolphe, AU - Akoum,Ali, Y1 - 2009/06/01/ PY - 2009/6/2/entrez PY - 2009/6/2/pubmed PY - 2010/6/17/medline SP - 415 EP - 28 JF - Frontiers in bioscience (Elite edition) JO - Front Biosci (Elite Ed) VL - 1 N2 - Endometriosis is defined as the presence of ectopic endometrial-like tissue outside the uterus cavity. This disease, afflicting women during their reproductive age, is mainly associated with pelvic pain and infertility. Sampson's theory which supports the ability of endometrial fragments from retrograde menstruations to slough through fallopian tubes and reach peritoneal environment has been recognized as the most plausible explanation for endometriosis during many years. However, further studies provided evidence that fundamental abnormal changes may occur within the eutopic endometrium of women with endometriosis compared to that of women without endometriosis. These dysfunctions included genetic predisposition, genes aberrantly expressed such as matrix metalloproteinases, Hox genes, integrins, anti-apoptotic genes Bcl-2, but also steroid hormones, immuno-inflammatory factors and angiogenesis. This review aims at summarizing and emphasizing a non exhaustive panel of biochemical and molecular factors abnormally expressed in the eutopic endometrium and related to the pathogenesis of endometriosis. SN - 1945-0508 UR - https://www.unboundmedicine.com/medline/citation/19482656/Insights_into_endometriosis_associated_endometrial_dysfunctions:_a_review_ L2 - https://www.bioscience.org/2009/v1e/af/38/fulltext.htm DB - PRIME DP - Unbound Medicine ER -