Tags

Type your tag names separated by a space and hit enter

Immune-endocrine interactions in endometriosis.
Front Biosci (Elite Ed). 2009 Jun 01; 1:429-43.FB

Abstract

Endocrine and immune systems are among the most essential regulators of endometrial physiology, and immune-endocrine interactions are likely to be involved in the pathogenesis of endometriosis. Endometriosis is an inflammatory, estrogen-dependent disease defined by the presence of viable endometrial tissue outside the uterine cavity. Impaired immune response that results in inadequate removal of refluxed menstrual debris has been proposed as a possible causative factor in the development of endometriosis. Moreover, decrease in spontaneous apoptosis of endometrium is the other theory proposed for the development of endometriosis. Endometriotic tissues respond to sex steroids aberrantly and behave differently compared to endometrium in addition to their ability to produce local estrogen. The effects of estrogen on distinct intracellular signaling pathways including MAPK, PI3K/AKT and NF-kappa B may take a role in enhanced endometrial cell survival, altered immune response, and differential cytokine and chemokine expression in endometriosis. Better understanding of immune-endocrine interactions will set the stage for effective immune-targeted therapies not only for endometriosis but also for other endometrial diseases such as adenomyosis, recurrent reproductive failure and implantation-related infertility.

Authors+Show Affiliations

Yale University School of Medicine, Department of Obstetrics, Gynecology & Reproductive Sciences, New Haven, CT 06510, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19482657

Citation

Cakmak, Hakan, et al. "Immune-endocrine Interactions in Endometriosis." Frontiers in Bioscience (Elite Edition), vol. 1, 2009, pp. 429-43.
Cakmak H, Guzeloglu-Kayisli O, Kayisli UA, et al. Immune-endocrine interactions in endometriosis. Front Biosci (Elite Ed). 2009;1:429-43.
Cakmak, H., Guzeloglu-Kayisli, O., Kayisli, U. A., & Arici, A. (2009). Immune-endocrine interactions in endometriosis. Frontiers in Bioscience (Elite Edition), 1, 429-43.
Cakmak H, et al. Immune-endocrine Interactions in Endometriosis. Front Biosci (Elite Ed). 2009 Jun 1;1:429-43. PubMed PMID: 19482657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immune-endocrine interactions in endometriosis. AU - Cakmak,Hakan, AU - Guzeloglu-Kayisli,Ozlem, AU - Kayisli,Umit Ali, AU - Arici,Aydin, Y1 - 2009/06/01/ PY - 2009/6/2/entrez PY - 2009/6/2/pubmed PY - 2010/6/17/medline SP - 429 EP - 43 JF - Frontiers in bioscience (Elite edition) JO - Front Biosci (Elite Ed) VL - 1 N2 - Endocrine and immune systems are among the most essential regulators of endometrial physiology, and immune-endocrine interactions are likely to be involved in the pathogenesis of endometriosis. Endometriosis is an inflammatory, estrogen-dependent disease defined by the presence of viable endometrial tissue outside the uterine cavity. Impaired immune response that results in inadequate removal of refluxed menstrual debris has been proposed as a possible causative factor in the development of endometriosis. Moreover, decrease in spontaneous apoptosis of endometrium is the other theory proposed for the development of endometriosis. Endometriotic tissues respond to sex steroids aberrantly and behave differently compared to endometrium in addition to their ability to produce local estrogen. The effects of estrogen on distinct intracellular signaling pathways including MAPK, PI3K/AKT and NF-kappa B may take a role in enhanced endometrial cell survival, altered immune response, and differential cytokine and chemokine expression in endometriosis. Better understanding of immune-endocrine interactions will set the stage for effective immune-targeted therapies not only for endometriosis but also for other endometrial diseases such as adenomyosis, recurrent reproductive failure and implantation-related infertility. SN - 1945-0508 UR - https://www.unboundmedicine.com/medline/citation/19482657/Immune_endocrine_interactions_in_endometriosis_ L2 - https://www.bioscience.org/2009/v1e/af/39/fulltext.htm DB - PRIME DP - Unbound Medicine ER -