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Targeting the adiponectin:leptin ratio for postmenopausal breast cancer prevention.
Front Biosci (Schol Ed) 2009; 1:329-57FB

Abstract

Obesity is a risk factor for postmenopausal breast cancer. Elevated estrogen levels are thought to be a growth factor associated with this relationship. However, there is increasing evidence that factors produced directly in adipose tissue, adipokines, specifically adiponectin and leptin, impact breast cancer development. Serum adiponectin levels are reduced in women diagnosed with breast cancer and in vitro studies using human breast cancer cell lines have shown antiproliferative action of adiponectin. In contrast, elevated serum leptin levels were associated with breast cancer in some studies. In mice which lack the leptin receptor or are leptin deficient oncogene-induced mammary tumors were not detected while leptin enhanced proliferation of breast cancer cell lines, particularly those that express estrogen receptors. Of particular interest, one recent study reported that the adiponectin:leptin ratio was reduced in women with breast cancer. Here we speculate that the ratio of these adipokines may be more important in breast cancer than their absolute concentrations. Additionally, we propose strategies to alter this ratio and thus provide protection against the development of breast cancer.

Authors+Show Affiliations

The Hormel Institute, University of Minnesota, Austin, MN 55912, USA. mpcleary@smig.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19482706

Citation

Cleary, Margot P., et al. "Targeting the Adiponectin:leptin Ratio for Postmenopausal Breast Cancer Prevention." Frontiers in Bioscience (Scholar Edition), vol. 1, 2009, pp. 329-57.
Cleary MP, Ray A, Rogozina OP, et al. Targeting the adiponectin:leptin ratio for postmenopausal breast cancer prevention. Front Biosci (Schol Ed). 2009;1:329-57.
Cleary, M. P., Ray, A., Rogozina, O. P., Dogan, S., & Grossmann, M. E. (2009). Targeting the adiponectin:leptin ratio for postmenopausal breast cancer prevention. Frontiers in Bioscience (Scholar Edition), 1, pp. 329-57.
Cleary MP, et al. Targeting the Adiponectin:leptin Ratio for Postmenopausal Breast Cancer Prevention. Front Biosci (Schol Ed). 2009 Jun 1;1:329-57. PubMed PMID: 19482706.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Targeting the adiponectin:leptin ratio for postmenopausal breast cancer prevention. AU - Cleary,Margot P, AU - Ray,Amitabha, AU - Rogozina,Olga P, AU - Dogan,Soner, AU - Grossmann,Michael E, Y1 - 2009/06/01/ PY - 2009/6/2/entrez PY - 2009/6/2/pubmed PY - 2010/7/2/medline SP - 329 EP - 57 JF - Frontiers in bioscience (Scholar edition) JO - Front Biosci (Schol Ed) VL - 1 N2 - Obesity is a risk factor for postmenopausal breast cancer. Elevated estrogen levels are thought to be a growth factor associated with this relationship. However, there is increasing evidence that factors produced directly in adipose tissue, adipokines, specifically adiponectin and leptin, impact breast cancer development. Serum adiponectin levels are reduced in women diagnosed with breast cancer and in vitro studies using human breast cancer cell lines have shown antiproliferative action of adiponectin. In contrast, elevated serum leptin levels were associated with breast cancer in some studies. In mice which lack the leptin receptor or are leptin deficient oncogene-induced mammary tumors were not detected while leptin enhanced proliferation of breast cancer cell lines, particularly those that express estrogen receptors. Of particular interest, one recent study reported that the adiponectin:leptin ratio was reduced in women with breast cancer. Here we speculate that the ratio of these adipokines may be more important in breast cancer than their absolute concentrations. Additionally, we propose strategies to alter this ratio and thus provide protection against the development of breast cancer. SN - 1945-0524 UR - https://www.unboundmedicine.com/medline/citation/19482706/Targeting_the_adiponectin:leptin_ratio_for_postmenopausal_breast_cancer_prevention_ L2 - https://www.bioscience.org/2009/v1s/af/30/fulltext.htm DB - PRIME DP - Unbound Medicine ER -