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Condensin function in dosage compensation.
Epigenetics. 2009 May 16; 4(4):212-5.E

Abstract

Dosage compensation is an essential process that equalizes X-linked gene dosage between the sexes. In the worm Caenorhabditis elegans, a complex of proteins called the dosage compensation complex (DCC) binds both X chromosomes in hermaphrodites to downregulate gene expression two-fold and hence to reduce X-linked gene expression levels equal to that in males. Five subunits of the DCC form the condensin I(DC) complex, a homolog of the evolutionarily conserved condensin complex required for chromosome segregation and compaction during mitosis and meiosis. How related complexes can perform such diverse functions remains a mystery. Nevertheless, it is believed that the mitotic and interphase functions of condensin are mechanistically related and understanding one process will reveal new insights into the other. We discuss how during worm dosage compensation a condensin-mediated function may guide the organization of the interphase chromatin fibers, leading to the formation of a repressive nuclear compartment.

Authors+Show Affiliations

Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-1048, USA. gyorgyi@umich.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

19483464

Citation

Csankovszki, Györgyi. "Condensin Function in Dosage Compensation." Epigenetics, vol. 4, no. 4, 2009, pp. 212-5.
Csankovszki G. Condensin function in dosage compensation. Epigenetics. 2009;4(4):212-5.
Csankovszki, G. (2009). Condensin function in dosage compensation. Epigenetics, 4(4), 212-5.
Csankovszki G. Condensin Function in Dosage Compensation. Epigenetics. 2009 May 16;4(4):212-5. PubMed PMID: 19483464.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Condensin function in dosage compensation. A1 - Csankovszki,Györgyi, Y1 - 2009/05/07/ PY - 2009/6/2/entrez PY - 2009/6/2/pubmed PY - 2009/10/10/medline SP - 212 EP - 5 JF - Epigenetics JO - Epigenetics VL - 4 IS - 4 N2 - Dosage compensation is an essential process that equalizes X-linked gene dosage between the sexes. In the worm Caenorhabditis elegans, a complex of proteins called the dosage compensation complex (DCC) binds both X chromosomes in hermaphrodites to downregulate gene expression two-fold and hence to reduce X-linked gene expression levels equal to that in males. Five subunits of the DCC form the condensin I(DC) complex, a homolog of the evolutionarily conserved condensin complex required for chromosome segregation and compaction during mitosis and meiosis. How related complexes can perform such diverse functions remains a mystery. Nevertheless, it is believed that the mitotic and interphase functions of condensin are mechanistically related and understanding one process will reveal new insights into the other. We discuss how during worm dosage compensation a condensin-mediated function may guide the organization of the interphase chromatin fibers, leading to the formation of a repressive nuclear compartment. SN - 1559-2308 UR - https://www.unboundmedicine.com/medline/citation/19483464/Condensin_function_in_dosage_compensation_ L2 - http://www.tandfonline.com/doi/full/10.4161/epi.8957 DB - PRIME DP - Unbound Medicine ER -