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Metastatic lymph node ratio as an independent prognostic variable in colorectal cancer: study of 113 patients.
Tech Coloproctol. 2009 Jun; 13(2):113-21.TC

Abstract

BACKGROUND

In patients with colorectal cancer, involvement of the lymph nodes is one of the most important prognostic factors. The aim of this study was to determine the independent prognostic value of the lymph node ratio (LNR), that is the relationship between the involved and examined lymph nodes, in patients with colorectal cancer.

METHODS

Included in the study were 113 patients with colorectal adenocarcinoma. The patients were divided into three groups according to the proportion of involved lymph nodes: LNR-0, when there was no lymph node involvement; LNR-1, when there was involvement of up to 20% of the examined lymph nodes, and LNR-2, when there was involvement of 21% or more of the examined nodes. The relationship between lymph node ratio, the number of lymph nodes removed, and the number of lymph nodes involved by cancer was determined. The 5-year survival was evaluated using the Kaplan-Meier test.

RESULTS

There was a significant difference in 5-year overall between patients in the different LNR groups (p=0.009). Patients in the LNR-0 group had a 5-year overall survival greater than 80%, while those in the LNR-1 and LNR-2 groups had 5-year overall survival rates less than 60% and 40%, respectively. Multivariate analysis demonstrated that the LNR is an independent prognostic variable in 5-year overall survival (p=0.009).

CONCLUSION

The results showed that the LNR can be considered an independent prognostic variable in overall survival of patients with colorectal cancer.

Authors+Show Affiliations

São Francisco University Medical School, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19484349

Citation

Priolli, D G., et al. "Metastatic Lymph Node Ratio as an Independent Prognostic Variable in Colorectal Cancer: Study of 113 Patients." Techniques in Coloproctology, vol. 13, no. 2, 2009, pp. 113-21.
Priolli DG, Cardinalli IA, Pereira JA, et al. Metastatic lymph node ratio as an independent prognostic variable in colorectal cancer: study of 113 patients. Tech Coloproctol. 2009;13(2):113-21.
Priolli, D. G., Cardinalli, I. A., Pereira, J. A., Alfredo, C. H., Margarido, N. F., & Martinez, C. A. (2009). Metastatic lymph node ratio as an independent prognostic variable in colorectal cancer: study of 113 patients. Techniques in Coloproctology, 13(2), 113-21. https://doi.org/10.1007/s10151-009-0467-5
Priolli DG, et al. Metastatic Lymph Node Ratio as an Independent Prognostic Variable in Colorectal Cancer: Study of 113 Patients. Tech Coloproctol. 2009;13(2):113-21. PubMed PMID: 19484349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metastatic lymph node ratio as an independent prognostic variable in colorectal cancer: study of 113 patients. AU - Priolli,D G, AU - Cardinalli,I Aparecida, AU - Pereira,J Aires, AU - Alfredo,C Helaehil, AU - Margarido,N Fontana, AU - Martinez,C A Real, Y1 - 2009/05/29/ PY - 2008/05/24/received PY - 2009/03/04/accepted PY - 2009/6/2/entrez PY - 2009/6/2/pubmed PY - 2009/10/23/medline SP - 113 EP - 21 JF - Techniques in coloproctology JO - Tech Coloproctol VL - 13 IS - 2 N2 - BACKGROUND: In patients with colorectal cancer, involvement of the lymph nodes is one of the most important prognostic factors. The aim of this study was to determine the independent prognostic value of the lymph node ratio (LNR), that is the relationship between the involved and examined lymph nodes, in patients with colorectal cancer. METHODS: Included in the study were 113 patients with colorectal adenocarcinoma. The patients were divided into three groups according to the proportion of involved lymph nodes: LNR-0, when there was no lymph node involvement; LNR-1, when there was involvement of up to 20% of the examined lymph nodes, and LNR-2, when there was involvement of 21% or more of the examined nodes. The relationship between lymph node ratio, the number of lymph nodes removed, and the number of lymph nodes involved by cancer was determined. The 5-year survival was evaluated using the Kaplan-Meier test. RESULTS: There was a significant difference in 5-year overall between patients in the different LNR groups (p=0.009). Patients in the LNR-0 group had a 5-year overall survival greater than 80%, while those in the LNR-1 and LNR-2 groups had 5-year overall survival rates less than 60% and 40%, respectively. Multivariate analysis demonstrated that the LNR is an independent prognostic variable in 5-year overall survival (p=0.009). CONCLUSION: The results showed that the LNR can be considered an independent prognostic variable in overall survival of patients with colorectal cancer. SN - 1128-045X UR - https://www.unboundmedicine.com/medline/citation/19484349/Metastatic_lymph_node_ratio_as_an_independent_prognostic_variable_in_colorectal_cancer:_study_of_113_patients_ L2 - https://dx.doi.org/10.1007/s10151-009-0467-5 DB - PRIME DP - Unbound Medicine ER -