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Diphenyl diselenide protects against glycerol-induced renal damage in rats.
J Appl Toxicol. 2009 Oct; 29(7):612-8.JA

Abstract

In this study we evaluated the effect of diphenyl diselenide (PhSe)(2) on glycerol-induced acute renal failure in rats. Rats were pre-treated by gavage every day with (PhSe)(2)(7.14 mg kg(-1)) for 7 days. On the eighth day, rats received an intramuscular injection of glycerol (8 mL kg(-1)). Twenty-four hours afterwards, rats were euthanized and the levels of urea and creatinine were measured in plasma. Catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), delta-aminolevulinate dehydratase (delta-ALA-D) and Na(+), K(+)-ATPase activities and ascorbic acid levels were evaluated in renal homogenates. Histopathological evaluations were also performed. The results demonstrated that (PhSe)(2) was able to protect against the increase in urea and creatinine levels and histological alterations in kidney induced by glycerol. (PhSe)(2) protected against the inhibition in delta-ALA-D, CAT and GPx activities and the reduction in ascorbic acid levels induced by glycerol in kidneys of rats. In conclusion, the present results indicate that (PhSe)(2) was effective in protecting against acute renal failure induced by glycerol.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19484701

Citation

Brandão, Ricardo, et al. "Diphenyl Diselenide Protects Against Glycerol-induced Renal Damage in Rats." Journal of Applied Toxicology : JAT, vol. 29, no. 7, 2009, pp. 612-8.
Brandão R, Acker CI, Leite MR, et al. Diphenyl diselenide protects against glycerol-induced renal damage in rats. J Appl Toxicol. 2009;29(7):612-8.
Brandão, R., Acker, C. I., Leite, M. R., Barbosa, N. B., & Nogueira, C. W. (2009). Diphenyl diselenide protects against glycerol-induced renal damage in rats. Journal of Applied Toxicology : JAT, 29(7), 612-8. https://doi.org/10.1002/jat.1449
Brandão R, et al. Diphenyl Diselenide Protects Against Glycerol-induced Renal Damage in Rats. J Appl Toxicol. 2009;29(7):612-8. PubMed PMID: 19484701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diphenyl diselenide protects against glycerol-induced renal damage in rats. AU - Brandão,Ricardo, AU - Acker,Carmine I, AU - Leite,Marlon R, AU - Barbosa,Nilda B V, AU - Nogueira,Cristina W, PY - 2009/6/2/entrez PY - 2009/6/2/pubmed PY - 2010/1/22/medline SP - 612 EP - 8 JF - Journal of applied toxicology : JAT JO - J Appl Toxicol VL - 29 IS - 7 N2 - In this study we evaluated the effect of diphenyl diselenide (PhSe)(2) on glycerol-induced acute renal failure in rats. Rats were pre-treated by gavage every day with (PhSe)(2)(7.14 mg kg(-1)) for 7 days. On the eighth day, rats received an intramuscular injection of glycerol (8 mL kg(-1)). Twenty-four hours afterwards, rats were euthanized and the levels of urea and creatinine were measured in plasma. Catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), delta-aminolevulinate dehydratase (delta-ALA-D) and Na(+), K(+)-ATPase activities and ascorbic acid levels were evaluated in renal homogenates. Histopathological evaluations were also performed. The results demonstrated that (PhSe)(2) was able to protect against the increase in urea and creatinine levels and histological alterations in kidney induced by glycerol. (PhSe)(2) protected against the inhibition in delta-ALA-D, CAT and GPx activities and the reduction in ascorbic acid levels induced by glycerol in kidneys of rats. In conclusion, the present results indicate that (PhSe)(2) was effective in protecting against acute renal failure induced by glycerol. SN - 1099-1263 UR - https://www.unboundmedicine.com/medline/citation/19484701/Diphenyl_diselenide_protects_against_glycerol_induced_renal_damage_in_rats_ L2 - https://doi.org/10.1002/jat.1449 DB - PRIME DP - Unbound Medicine ER -