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Infections caused by Candida krusei in five transplant and two surgical patients.
Surg Infect (Larchmt). 2009 Jun; 10(3):265-71.SI

Abstract

BACKGROUND

Candida krusei (Ck) may cause severe infections in immunocompromised hosts and is innately resistant to fluconazole.

PATIENTS AND METHODS

During an 18-month period, seven patients with Ck infection were identified at our center. All were treated in the transplant intensive care unit. Candida isolates were grown on Sabouraud agar, and chromosomal DNA was extracted; clonality was investigated using random amplified polymorphic DNA-polymerase chain reaction with primers M13, OPA-18, and OPE-18.

RESULTS

Among the patients with Ck infection, there were three pancreas recipients with intra-abdominal infection, one liver recipient with cholangitis, one lung recipient with pleural empyema, one patient with pleural empyema after esophageal perforation, and one case of pneumonia in a patient with a ventricular assist device. Treatment consisted of caspofungin (n = 3), voriconazole (n = 1), or a combination of the two (n = 2) together with surgery (n = 3) or pigtail catheter drainage (n = 3). One patient underwent drainage without antifungal treatment, and one patient did not have drainage. The infection was controlled in all cases. The patient with the assist device died from multiple organ dysfunction, the lung recipient died after four months from graft failure, and one pancreas graft was lost. Four patients (57%) harbored the same Ck strain.

CONCLUSION

Solid organ recipients seem to be at particular risk for Ck infections; clonal outbreaks may occur in intensive care units.

Authors+Show Affiliations

Department of General and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria. Hugo.Bonatti@dr.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19485782

Citation

Bonatti, Hugo, et al. "Infections Caused By Candida Krusei in Five Transplant and Two Surgical Patients." Surgical Infections, vol. 10, no. 3, 2009, pp. 265-71.
Bonatti H, Stelzmueller I, Berger N, et al. Infections caused by Candida krusei in five transplant and two surgical patients. Surg Infect (Larchmt). 2009;10(3):265-71.
Bonatti, H., Stelzmueller, I., Berger, N., Lechner, M., Lechner, M., Grif, K., Geltner, C., Margreiter, R., & Lass-Flörl, C. (2009). Infections caused by Candida krusei in five transplant and two surgical patients. Surgical Infections, 10(3), 265-71. https://doi.org/10.1089/sur.2008.073
Bonatti H, et al. Infections Caused By Candida Krusei in Five Transplant and Two Surgical Patients. Surg Infect (Larchmt). 2009;10(3):265-71. PubMed PMID: 19485782.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Infections caused by Candida krusei in five transplant and two surgical patients. AU - Bonatti,Hugo, AU - Stelzmueller,Ingrid, AU - Berger,Natalie, AU - Lechner,Matthias, AU - Lechner,Mathias, AU - Grif,Katharina, AU - Geltner,Christian, AU - Margreiter,Raimund, AU - Lass-Flörl,Cornelia, PY - 2009/6/3/entrez PY - 2009/6/3/pubmed PY - 2009/8/28/medline SP - 265 EP - 71 JF - Surgical infections JO - Surg Infect (Larchmt) VL - 10 IS - 3 N2 - BACKGROUND: Candida krusei (Ck) may cause severe infections in immunocompromised hosts and is innately resistant to fluconazole. PATIENTS AND METHODS: During an 18-month period, seven patients with Ck infection were identified at our center. All were treated in the transplant intensive care unit. Candida isolates were grown on Sabouraud agar, and chromosomal DNA was extracted; clonality was investigated using random amplified polymorphic DNA-polymerase chain reaction with primers M13, OPA-18, and OPE-18. RESULTS: Among the patients with Ck infection, there were three pancreas recipients with intra-abdominal infection, one liver recipient with cholangitis, one lung recipient with pleural empyema, one patient with pleural empyema after esophageal perforation, and one case of pneumonia in a patient with a ventricular assist device. Treatment consisted of caspofungin (n = 3), voriconazole (n = 1), or a combination of the two (n = 2) together with surgery (n = 3) or pigtail catheter drainage (n = 3). One patient underwent drainage without antifungal treatment, and one patient did not have drainage. The infection was controlled in all cases. The patient with the assist device died from multiple organ dysfunction, the lung recipient died after four months from graft failure, and one pancreas graft was lost. Four patients (57%) harbored the same Ck strain. CONCLUSION: Solid organ recipients seem to be at particular risk for Ck infections; clonal outbreaks may occur in intensive care units. SN - 1557-8674 UR - https://www.unboundmedicine.com/medline/citation/19485782/Infections_caused_by_Candida_krusei_in_five_transplant_and_two_surgical_patients_ L2 - https://www.liebertpub.com/doi/10.1089/sur.2008.073?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -