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Response of cutaneous microcirculation to treatment with mometasone furoate in patients with psoriasis.
Clin Exp Dermatol. 2009 Dec; 34(8):915-9.CE

Abstract

BACKGROUND

In patients with psoriasis, videocapillaroscopy has been used to visualize the typical modifications in the microcirculatory architecture.

AIM

To evaluate the modifications of the superficial capillary bed in a psoriatic plaque and healthy perilesional skin during treatment with a topical steroid.

METHODS

In total, 24 patients affected with psoriasis vulgaris were enrolled. Each patient was instructed to apply mometasone furoate cream 0.1% once daily to a selected psoriatic lesion for 12 weeks. At baseline (T0) and after 4 (T1), 8 (T2) and 12 (T3) weeks, clinical and capillaroscopic examination was made of the psoriatic plaque and the surrounding skin.

RESULTS

At the end of the study, the diameters of dilated and convoluted capillaries in the psoriatic plaque were significantly reduced (baseline, 69.2 microm; after 12 weeks, 29.3 microm; P < 0.0001) in all subjects. A marked clinical improvement was also noted (plaque score: baseline, 7.4; after 12 weeks, 0.5; P < 0.0001). The perilesional skin also showed improvement in capillaroscopic alterations, even if the drug had not been applied to those areas. Of the 24 patients, 12 were clinically healed at the end of the treatment period, although the capillaroscopic picture returned to normal in only 2 of them.

CONCLUSIONS

Mometasone furoate cream proved to be effective in reducing the clinical and capillaroscopic alterations of the psoriatic plaque, but there was no association between clinical improvement and microcirculatory alterations noted. The action of mometasone furoate action on the microcirculation was not limited only to the area of application, but also extended to the surrounding areas.

Authors+Show Affiliations

Department of Clinical and Experimental Pathology and Medicine, Institute of Dermatology, University of Udine School of Medicine, Udine, Italy. giuseppe.stinco@uniud.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

19486040

Citation

Stinco, G, et al. "Response of Cutaneous Microcirculation to Treatment With Mometasone Furoate in Patients With Psoriasis." Clinical and Experimental Dermatology, vol. 34, no. 8, 2009, pp. 915-9.
Stinco G, Lautieri S, Piccirillo F, et al. Response of cutaneous microcirculation to treatment with mometasone furoate in patients with psoriasis. Clin Exp Dermatol. 2009;34(8):915-9.
Stinco, G., Lautieri, S., Piccirillo, F., Valent, F., & Patrone, P. (2009). Response of cutaneous microcirculation to treatment with mometasone furoate in patients with psoriasis. Clinical and Experimental Dermatology, 34(8), 915-9. https://doi.org/10.1111/j.1365-2230.2009.03298.x
Stinco G, et al. Response of Cutaneous Microcirculation to Treatment With Mometasone Furoate in Patients With Psoriasis. Clin Exp Dermatol. 2009;34(8):915-9. PubMed PMID: 19486040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Response of cutaneous microcirculation to treatment with mometasone furoate in patients with psoriasis. AU - Stinco,G, AU - Lautieri,S, AU - Piccirillo,F, AU - Valent,F, AU - Patrone,P, Y1 - 2009/05/22/ PY - 2009/6/3/entrez PY - 2009/6/3/pubmed PY - 2010/8/19/medline SP - 915 EP - 9 JF - Clinical and experimental dermatology JO - Clin Exp Dermatol VL - 34 IS - 8 N2 - BACKGROUND: In patients with psoriasis, videocapillaroscopy has been used to visualize the typical modifications in the microcirculatory architecture. AIM: To evaluate the modifications of the superficial capillary bed in a psoriatic plaque and healthy perilesional skin during treatment with a topical steroid. METHODS: In total, 24 patients affected with psoriasis vulgaris were enrolled. Each patient was instructed to apply mometasone furoate cream 0.1% once daily to a selected psoriatic lesion for 12 weeks. At baseline (T0) and after 4 (T1), 8 (T2) and 12 (T3) weeks, clinical and capillaroscopic examination was made of the psoriatic plaque and the surrounding skin. RESULTS: At the end of the study, the diameters of dilated and convoluted capillaries in the psoriatic plaque were significantly reduced (baseline, 69.2 microm; after 12 weeks, 29.3 microm; P < 0.0001) in all subjects. A marked clinical improvement was also noted (plaque score: baseline, 7.4; after 12 weeks, 0.5; P < 0.0001). The perilesional skin also showed improvement in capillaroscopic alterations, even if the drug had not been applied to those areas. Of the 24 patients, 12 were clinically healed at the end of the treatment period, although the capillaroscopic picture returned to normal in only 2 of them. CONCLUSIONS: Mometasone furoate cream proved to be effective in reducing the clinical and capillaroscopic alterations of the psoriatic plaque, but there was no association between clinical improvement and microcirculatory alterations noted. The action of mometasone furoate action on the microcirculation was not limited only to the area of application, but also extended to the surrounding areas. SN - 1365-2230 UR - https://www.unboundmedicine.com/medline/citation/19486040/Response_of_cutaneous_microcirculation_to_treatment_with_mometasone_furoate_in_patients_with_psoriasis_ L2 - https://doi.org/10.1111/j.1365-2230.2009.03298.x DB - PRIME DP - Unbound Medicine ER -