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Genetic diversity and geographic distribution of hantaviruses in Russia.
Zoonoses Public Health. 2009 Aug; 56(6-7):297-309.ZP

Abstract

Haemorrhagic fever with renal syndrome (HFRS) is the most prevalent zoonotic disease in Russia. It is caused by several hantavirus species hosted by small rodents. We describe spatial and temporal patterns of HFRS incidence in the Russian Federation, and the geographic distribution of prevalent hantavirus species: Puumala (PUUV) and Dobrava (DOBV). Partial sequencing of nucleocapsid and glycoprotein genes of 117 PUUV strains and 78 DOBV strains revealed several distinct genetic subgroups. The RNA of Volga PUUV subgroup was detected in patients with HFRS and bank voles Myodes glareolus in the Volga Federal District, where the highest HFRS incidence rate has been registered yearly. The RNA of Siberian PUUV subgroup was found in M. glareolus in the trans-Ural Tyumen and Omsk Provinces, where human HFRS cases have been rare. During an HFRS outbreak in 2007 in the Central Federal District, when more than 1000 patients were affected, specific subgroups of DOBV were discovered in patients and rodents, mainly in the striped field mouse Apodemus agrarius. DOBV strains might have 8–9% of nucleotide difference although they were collected at places separated by 30–100 km. The RNA of a unique DOBV subgroup was discovered in the southern semi-desert Astrakhan Province, mainly in A. agrarius and tamarisk jird Meriones tamariscinus. No human HFRS cases were diagnosed in this province. Russian PUUV and DOBV strains have no close homologues among European strains. Our DOBV strains might be genetically grouped together with Central European DOBV strains isolated from A. agrarius, but not from Apodemus flavicollis. The Volga PUUV subgroup is to some extent similar to Baltic PUUV strain, and Finnish PUUV strains resemble the strains from the Siberian PUUV subgroup. Thus, PCRbased monitoring and typing provided the opportunity to delineate and expand the area of hantaviruses in Russia and to identify their new genetic variants.

Authors+Show Affiliations

Central Research Institute of Epidemiology, Moscow, Russia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19486318

Citation

Garanina, S B., et al. "Genetic Diversity and Geographic Distribution of Hantaviruses in Russia." Zoonoses and Public Health, vol. 56, no. 6-7, 2009, pp. 297-309.
Garanina SB, Platonov AE, Zhuravlev VI, et al. Genetic diversity and geographic distribution of hantaviruses in Russia. Zoonoses Public Health. 2009;56(6-7):297-309.
Garanina, S. B., Platonov, A. E., Zhuravlev, V. I., Murashkina, A. N., Yakimenko, V. V., Korneev, A. G., & Shipulin, G. A. (2009). Genetic diversity and geographic distribution of hantaviruses in Russia. Zoonoses and Public Health, 56(6-7), 297-309. https://doi.org/10.1111/j.1863-2378.2008.01210.x
Garanina SB, et al. Genetic Diversity and Geographic Distribution of Hantaviruses in Russia. Zoonoses Public Health. 2009;56(6-7):297-309. PubMed PMID: 19486318.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic diversity and geographic distribution of hantaviruses in Russia. AU - Garanina,S B, AU - Platonov,A E, AU - Zhuravlev,V I, AU - Murashkina,A N, AU - Yakimenko,V V, AU - Korneev,A G, AU - Shipulin,G A, PY - 2009/6/3/entrez PY - 2009/6/3/pubmed PY - 2011/4/8/medline SP - 297 EP - 309 JF - Zoonoses and public health JO - Zoonoses Public Health VL - 56 IS - 6-7 N2 - Haemorrhagic fever with renal syndrome (HFRS) is the most prevalent zoonotic disease in Russia. It is caused by several hantavirus species hosted by small rodents. We describe spatial and temporal patterns of HFRS incidence in the Russian Federation, and the geographic distribution of prevalent hantavirus species: Puumala (PUUV) and Dobrava (DOBV). Partial sequencing of nucleocapsid and glycoprotein genes of 117 PUUV strains and 78 DOBV strains revealed several distinct genetic subgroups. The RNA of Volga PUUV subgroup was detected in patients with HFRS and bank voles Myodes glareolus in the Volga Federal District, where the highest HFRS incidence rate has been registered yearly. The RNA of Siberian PUUV subgroup was found in M. glareolus in the trans-Ural Tyumen and Omsk Provinces, where human HFRS cases have been rare. During an HFRS outbreak in 2007 in the Central Federal District, when more than 1000 patients were affected, specific subgroups of DOBV were discovered in patients and rodents, mainly in the striped field mouse Apodemus agrarius. DOBV strains might have 8–9% of nucleotide difference although they were collected at places separated by 30–100 km. The RNA of a unique DOBV subgroup was discovered in the southern semi-desert Astrakhan Province, mainly in A. agrarius and tamarisk jird Meriones tamariscinus. No human HFRS cases were diagnosed in this province. Russian PUUV and DOBV strains have no close homologues among European strains. Our DOBV strains might be genetically grouped together with Central European DOBV strains isolated from A. agrarius, but not from Apodemus flavicollis. The Volga PUUV subgroup is to some extent similar to Baltic PUUV strain, and Finnish PUUV strains resemble the strains from the Siberian PUUV subgroup. Thus, PCRbased monitoring and typing provided the opportunity to delineate and expand the area of hantaviruses in Russia and to identify their new genetic variants. SN - 1863-2378 UR - https://www.unboundmedicine.com/medline/citation/19486318/Genetic_diversity_and_geographic_distribution_of_hantaviruses_in_Russia_ L2 - https://doi.org/10.1111/j.1863-2378.2008.01210.x DB - PRIME DP - Unbound Medicine ER -