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Sensitization to amphetamine occurs simultaneously at immune level and in met-enkephalin of the nucleus accumbens and spleen: an involved NMDA glutamatergic mechanism.
Brain Behav Immun. 2009 May; 23(4):464-73.BB

Abstract

Administration of psychostimulants can elicit a sensitized response to the stimulating and reinforcing properties of the drugs, although there is scarce information regarding their effects at immune level. We previously demonstrated that an acute exposure to amphetamine (5 mg/kg, i.p.) induced an inhibitory effect on the splenic T-cell proliferative response, along with an increase in met-enkephalin at limbic and immune levels, 4 days following drug administration. In this study, we evaluated the amphetamine-induced effects at weeks one and three after the same single dose treatment (5 mg/kg, i.p.) on the lymphoproliferative response and on the met-enkephalin in the nucleus accumbens (NAc), prefrontal cortex (PfC), spleen and thymus. It was demonstrated that these effects disappeared completely after three weeks, although re-exposure to an amphetamine challenge induced the expression of sensitization to the effects of amphetamine on the lymphoproliferative response and on the met-enkephalin from NAc, spleen and thymus, but not in the PfC. Pre-treatment with MK-801 (0.1 mg/kg, i.p.), an N-methyl-d-aspartate (NMDA) glutamatergic receptor antagonist, blocked the effects of a single amphetamine exposure on the lymphoproliferative response and on met-enkephalin in the NAc and spleen. Furthermore, the NMDA receptor antagonist administered prior to amphetamine challenge also blocked the expression of sensitization in both parameters evaluated. These findings show a long-lasting amphetamine-induced sensitization phenomenon at the immune level in a parallel way to that occurring in the limbic and immune enkephalineric system. A glutamate mechanism is implied in the long-term amphetamine-induced effects at immune level and in the met-enkephalin from NAc and spleen.

Authors+Show Affiliations

National University of Córdoba, School of Chemical Sciences, Department of Pharmacology, Instituto de Farmacología Experimental de Córdoba-CONICET, Medina Allende y Haya de la Torre, Ciudad Universitaria, X5000HUA Córdoba, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19486656

Citation

Assis, María Amparo, et al. "Sensitization to Amphetamine Occurs Simultaneously at Immune Level and in Met-enkephalin of the Nucleus Accumbens and Spleen: an Involved NMDA Glutamatergic Mechanism." Brain, Behavior, and Immunity, vol. 23, no. 4, 2009, pp. 464-73.
Assis MA, Hansen C, Lux-Lantos V, et al. Sensitization to amphetamine occurs simultaneously at immune level and in met-enkephalin of the nucleus accumbens and spleen: an involved NMDA glutamatergic mechanism. Brain Behav Immun. 2009;23(4):464-73.
Assis, M. A., Hansen, C., Lux-Lantos, V., & Cancela, L. M. (2009). Sensitization to amphetamine occurs simultaneously at immune level and in met-enkephalin of the nucleus accumbens and spleen: an involved NMDA glutamatergic mechanism. Brain, Behavior, and Immunity, 23(4), 464-73. https://doi.org/10.1016/j.bbi.2009.01.003
Assis MA, et al. Sensitization to Amphetamine Occurs Simultaneously at Immune Level and in Met-enkephalin of the Nucleus Accumbens and Spleen: an Involved NMDA Glutamatergic Mechanism. Brain Behav Immun. 2009;23(4):464-73. PubMed PMID: 19486656.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sensitization to amphetamine occurs simultaneously at immune level and in met-enkephalin of the nucleus accumbens and spleen: an involved NMDA glutamatergic mechanism. AU - Assis,María Amparo, AU - Hansen,Cristian, AU - Lux-Lantos,Victoria, AU - Cancela,Liliana Marina, Y1 - 2009/01/14/ PY - 2008/09/02/received PY - 2009/01/06/revised PY - 2009/01/06/accepted PY - 2009/6/3/entrez PY - 2009/6/3/pubmed PY - 2009/12/16/medline SP - 464 EP - 73 JF - Brain, behavior, and immunity JO - Brain Behav Immun VL - 23 IS - 4 N2 - Administration of psychostimulants can elicit a sensitized response to the stimulating and reinforcing properties of the drugs, although there is scarce information regarding their effects at immune level. We previously demonstrated that an acute exposure to amphetamine (5 mg/kg, i.p.) induced an inhibitory effect on the splenic T-cell proliferative response, along with an increase in met-enkephalin at limbic and immune levels, 4 days following drug administration. In this study, we evaluated the amphetamine-induced effects at weeks one and three after the same single dose treatment (5 mg/kg, i.p.) on the lymphoproliferative response and on the met-enkephalin in the nucleus accumbens (NAc), prefrontal cortex (PfC), spleen and thymus. It was demonstrated that these effects disappeared completely after three weeks, although re-exposure to an amphetamine challenge induced the expression of sensitization to the effects of amphetamine on the lymphoproliferative response and on the met-enkephalin from NAc, spleen and thymus, but not in the PfC. Pre-treatment with MK-801 (0.1 mg/kg, i.p.), an N-methyl-d-aspartate (NMDA) glutamatergic receptor antagonist, blocked the effects of a single amphetamine exposure on the lymphoproliferative response and on met-enkephalin in the NAc and spleen. Furthermore, the NMDA receptor antagonist administered prior to amphetamine challenge also blocked the expression of sensitization in both parameters evaluated. These findings show a long-lasting amphetamine-induced sensitization phenomenon at the immune level in a parallel way to that occurring in the limbic and immune enkephalineric system. A glutamate mechanism is implied in the long-term amphetamine-induced effects at immune level and in the met-enkephalin from NAc and spleen. SN - 1090-2139 UR - https://www.unboundmedicine.com/medline/citation/19486656/Sensitization_to_amphetamine_occurs_simultaneously_at_immune_level_and_in_met_enkephalin_of_the_nucleus_accumbens_and_spleen:_an_involved_NMDA_glutamatergic_mechanism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-1591(09)00006-3 DB - PRIME DP - Unbound Medicine ER -