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Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells.
J Exp Med. 2009 Jun 08; 206(6):1303-16.JE

Abstract

We describe new T cell receptor (TCR) transgenic mice (relapsing-remitting [RR] mice) carrying a TCR specific for myelin oligodendrocyte glycoprotein (MOG) peptide 92-106 in the context of I-A(s). Backcrossed to the SJL/J background, most RR mice spontaneously develop RR experimental autoimmune encephalomyelitis (EAE) with episodes often altering between different central nervous system tissues like the cerebellum, optic nerve, and spinal cord. Development of spontaneous EAE depends on the presence of an intact B cell compartment and on the expression of MOG autoantigen. There is no spontaneous EAE development in B cell-depleted mice or in transgenic mice lacking MOG. Transgenic T cells seem to expand MOG autoreactive B cells from the endogenous repertoire. The expanded autoreactive B cells produce autoantibodies binding to a conformational epitope on the native MOG protein while ignoring the T cell target peptide. The secreted autoantibodies are pathogenic, enhancing demyelinating EAE episodes. RR mice constitute the first spontaneous animal model for the most common form of multiple sclerosis (MS), RR MS.

Authors+Show Affiliations

Department of Neuroimmunology, Max Planck Institute of Neurobiology, D-82152 Martinsried, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19487416

Citation

Pöllinger, Bernadette, et al. "Spontaneous Relapsing-remitting EAE in the SJL/J Mouse: MOG-reactive Transgenic T Cells Recruit Endogenous MOG-specific B Cells." The Journal of Experimental Medicine, vol. 206, no. 6, 2009, pp. 1303-16.
Pöllinger B, Krishnamoorthy G, Berer K, et al. Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. J Exp Med. 2009;206(6):1303-16.
Pöllinger, B., Krishnamoorthy, G., Berer, K., Lassmann, H., Bösl, M. R., Dunn, R., Domingues, H. S., Holz, A., Kurschus, F. C., & Wekerle, H. (2009). Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. The Journal of Experimental Medicine, 206(6), 1303-16. https://doi.org/10.1084/jem.20090299
Pöllinger B, et al. Spontaneous Relapsing-remitting EAE in the SJL/J Mouse: MOG-reactive Transgenic T Cells Recruit Endogenous MOG-specific B Cells. J Exp Med. 2009 Jun 8;206(6):1303-16. PubMed PMID: 19487416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. AU - Pöllinger,Bernadette, AU - Krishnamoorthy,Gurumoorthy, AU - Berer,Kerstin, AU - Lassmann,Hans, AU - Bösl,Michael R, AU - Dunn,Robert, AU - Domingues,Helena S, AU - Holz,Andreas, AU - Kurschus,Florian C, AU - Wekerle,Hartmut, Y1 - 2009/06/01/ PY - 2009/6/3/entrez PY - 2009/6/3/pubmed PY - 2009/7/8/medline SP - 1303 EP - 16 JF - The Journal of experimental medicine JO - J Exp Med VL - 206 IS - 6 N2 - We describe new T cell receptor (TCR) transgenic mice (relapsing-remitting [RR] mice) carrying a TCR specific for myelin oligodendrocyte glycoprotein (MOG) peptide 92-106 in the context of I-A(s). Backcrossed to the SJL/J background, most RR mice spontaneously develop RR experimental autoimmune encephalomyelitis (EAE) with episodes often altering between different central nervous system tissues like the cerebellum, optic nerve, and spinal cord. Development of spontaneous EAE depends on the presence of an intact B cell compartment and on the expression of MOG autoantigen. There is no spontaneous EAE development in B cell-depleted mice or in transgenic mice lacking MOG. Transgenic T cells seem to expand MOG autoreactive B cells from the endogenous repertoire. The expanded autoreactive B cells produce autoantibodies binding to a conformational epitope on the native MOG protein while ignoring the T cell target peptide. The secreted autoantibodies are pathogenic, enhancing demyelinating EAE episodes. RR mice constitute the first spontaneous animal model for the most common form of multiple sclerosis (MS), RR MS. SN - 1540-9538 UR - https://www.unboundmedicine.com/medline/citation/19487416/Spontaneous_relapsing_remitting_EAE_in_the_SJL/J_mouse:_MOG_reactive_transgenic_T_cells_recruit_endogenous_MOG_specific_B_cells_ L2 - https://rupress.org/jem/article-lookup/doi/10.1084/jem.20090299 DB - PRIME DP - Unbound Medicine ER -