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Clinical, histological and electron microscopic aspects of vocal fold granulomas.
Braz J Otorhinolaryngol. 2009 Jan-Feb; 75(1):116-22.BJ

Abstract

Granulomas are bilateral and pediculated lesions of the vocal apophysis. Etiologies: intubation, reflux, trauma, vocal abuse, idiopathic origin.

AIM

To analyze the clinical and morphological aspects of post intubation granulomas.

METHODS

retrospective study of patients submitted to microsurgery for post intubation laryngeal granulomas seen at our Medical School starting in 2002. We analyzed: age, gender, indication and time of intubation, symptoms, videolaryngoscopic diagnosis and biopsy findings. Light microscopy was performed on all specimens, and electron microscopy on three of them.

RESULTS

ten patients (7 females and 3 males), between the ages of 2 and 72 years, intubation time between 4h and 21 days. Hoarseness was a frequent symptom, starting in the first week following extubation. Histology shows mild epithelial hyperplasia, severe inflammation and vessel proliferation in the corion. Under SEM, the epithelium presented mild superficial desquamation. Under TEM, intracellular junctions showed widening with structural changes in the desmosomes. In the corion there were vessel proliferations, inflammation and fibroblasts with structural alterations.

CONCLUSIONS

post intubation granulomas appear in any age and hoarseness is a frequent symptom. Morphological alterations occur in the corion as vessel proliferations, inflammation, and intracytoplasmatic alterations in fibroblasts suggesting cellular dysfunction and damage.

Authors+Show Affiliations

Faculdade de Medicina de Botucatu, Unesp.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19488571

Citation

Martins, Regina Helena Garcia, et al. "Clinical, Histological and Electron Microscopic Aspects of Vocal Fold Granulomas." Brazilian Journal of Otorhinolaryngology, vol. 75, no. 1, 2009, pp. 116-22.
Martins RH, Dias NH, Santos DC, et al. Clinical, histological and electron microscopic aspects of vocal fold granulomas. Braz J Otorhinolaryngol. 2009;75(1):116-22.
Martins, R. H., Dias, N. H., Santos, D. C., Fabro, A. T., & Braz, J. R. (2009). Clinical, histological and electron microscopic aspects of vocal fold granulomas. Brazilian Journal of Otorhinolaryngology, 75(1), 116-22.
Martins RH, et al. Clinical, Histological and Electron Microscopic Aspects of Vocal Fold Granulomas. Braz J Otorhinolaryngol. 2009 Jan-Feb;75(1):116-22. PubMed PMID: 19488571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical, histological and electron microscopic aspects of vocal fold granulomas. AU - Martins,Regina Helena Garcia, AU - Dias,Norimar Hernandes, AU - Santos,Daniela Carvalho Dos, AU - Fabro,Alexandre Todorovic, AU - Braz,José Reinaldo Cerqueira, PY - 2007/09/21/received PY - 2008/01/02/accepted PY - 2009/6/3/entrez PY - 2009/6/3/pubmed PY - 2010/2/5/medline SP - 116 EP - 22 JF - Brazilian journal of otorhinolaryngology JO - Braz J Otorhinolaryngol VL - 75 IS - 1 N2 - UNLABELLED: Granulomas are bilateral and pediculated lesions of the vocal apophysis. Etiologies: intubation, reflux, trauma, vocal abuse, idiopathic origin. AIM: To analyze the clinical and morphological aspects of post intubation granulomas. METHODS: retrospective study of patients submitted to microsurgery for post intubation laryngeal granulomas seen at our Medical School starting in 2002. We analyzed: age, gender, indication and time of intubation, symptoms, videolaryngoscopic diagnosis and biopsy findings. Light microscopy was performed on all specimens, and electron microscopy on three of them. RESULTS: ten patients (7 females and 3 males), between the ages of 2 and 72 years, intubation time between 4h and 21 days. Hoarseness was a frequent symptom, starting in the first week following extubation. Histology shows mild epithelial hyperplasia, severe inflammation and vessel proliferation in the corion. Under SEM, the epithelium presented mild superficial desquamation. Under TEM, intracellular junctions showed widening with structural changes in the desmosomes. In the corion there were vessel proliferations, inflammation and fibroblasts with structural alterations. CONCLUSIONS: post intubation granulomas appear in any age and hoarseness is a frequent symptom. Morphological alterations occur in the corion as vessel proliferations, inflammation, and intracytoplasmatic alterations in fibroblasts suggesting cellular dysfunction and damage. SN - 1808-8694 UR - https://www.unboundmedicine.com/medline/citation/19488571/Clinical_histological_and_electron_microscopic_aspects_of_vocal_fold_granulomas_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1808-8694(15)30842-9 DB - PRIME DP - Unbound Medicine ER -