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Effect of individualized weight-loss programmes on adiponectin, leptin and resistin levels in obese adolescent boys.
Acta Paediatr. 2009 Sep; 98(9):1487-93.AP

Abstract

AIM

We investigate the effects of a 2-month weight-loss programme on plasma levels of adiponectin, leptin and resistin in obese adolescent boys.

METHODS

Twenty-one obese adolescent boys (BMI = 30.8 +/- 3.2 kg/m(2)) completed the weight-loss programme including: 1/ either energy restriction (R), 2/ or individualized exercise training at the point of maximum lipid oxidation (Lipox(max)) (E), 3/ or energy restriction and training (RE). Body composition, lipid oxidation and plasma levels of adiponectin, leptin and resistin were measured before and after intervention.

RESULTS

Following the weight-loss programme, adolescents of the RE group showed an improvement of their body composition (p < 0.01), an increase in plasma adiponectin (+73.7%, p < 0.01) and a decrease in plasma leptin (-38.8%, p < 0.01) leading to an increase in adiponectine/leptin ratio (ALR, +144.4%, p < 0.01) higher than the R or E groups. E and RE groups only showed a similar significant increase in plasma resistin (p < 0.05) and a significant improvement of lipid oxidation rate at Lipox(max) (p < 0.01 and p < 0.001). In addition, in RE group, ALR is correlated with waist/hip and waist/height ratios, resistin level, homoeostasis mode assessment (HOMA-IR) index and Lipox(max).

CONCLUSION

In obese adolescents boys, moderate exercise training completed at Lipox(max) and combined with energy restriction improves their ability to oxidize lipids, which is associated with a normalization of their adiponectin, leptin and resistin levels resulting in an improved insulin sensitivity, as attested by a higher ALR and a lower HOMA-IR.

Authors+Show Affiliations

Laboratory of Exercise Biology (BAPS), Blaise Pascal University, Bat Biologie B, Aubière, France. elloumimed@yahoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19489770

Citation

Elloumi, M, et al. "Effect of Individualized Weight-loss Programmes On Adiponectin, Leptin and Resistin Levels in Obese Adolescent Boys." Acta Paediatrica (Oslo, Norway : 1992), vol. 98, no. 9, 2009, pp. 1487-93.
Elloumi M, Ben Ounis O, Makni E, et al. Effect of individualized weight-loss programmes on adiponectin, leptin and resistin levels in obese adolescent boys. Acta Paediatr. 2009;98(9):1487-93.
Elloumi, M., Ben Ounis, O., Makni, E., Van Praagh, E., Tabka, Z., & Lac, G. (2009). Effect of individualized weight-loss programmes on adiponectin, leptin and resistin levels in obese adolescent boys. Acta Paediatrica (Oslo, Norway : 1992), 98(9), 1487-93. https://doi.org/10.1111/j.1651-2227.2009.01365.x
Elloumi M, et al. Effect of Individualized Weight-loss Programmes On Adiponectin, Leptin and Resistin Levels in Obese Adolescent Boys. Acta Paediatr. 2009;98(9):1487-93. PubMed PMID: 19489770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of individualized weight-loss programmes on adiponectin, leptin and resistin levels in obese adolescent boys. AU - Elloumi,M, AU - Ben Ounis,O, AU - Makni,E, AU - Van Praagh,E, AU - Tabka,Z, AU - Lac,G, Y1 - 2009/06/01/ PY - 2009/6/4/entrez PY - 2009/6/6/pubmed PY - 2009/10/21/medline SP - 1487 EP - 93 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr VL - 98 IS - 9 N2 - AIM: We investigate the effects of a 2-month weight-loss programme on plasma levels of adiponectin, leptin and resistin in obese adolescent boys. METHODS: Twenty-one obese adolescent boys (BMI = 30.8 +/- 3.2 kg/m(2)) completed the weight-loss programme including: 1/ either energy restriction (R), 2/ or individualized exercise training at the point of maximum lipid oxidation (Lipox(max)) (E), 3/ or energy restriction and training (RE). Body composition, lipid oxidation and plasma levels of adiponectin, leptin and resistin were measured before and after intervention. RESULTS: Following the weight-loss programme, adolescents of the RE group showed an improvement of their body composition (p < 0.01), an increase in plasma adiponectin (+73.7%, p < 0.01) and a decrease in plasma leptin (-38.8%, p < 0.01) leading to an increase in adiponectine/leptin ratio (ALR, +144.4%, p < 0.01) higher than the R or E groups. E and RE groups only showed a similar significant increase in plasma resistin (p < 0.05) and a significant improvement of lipid oxidation rate at Lipox(max) (p < 0.01 and p < 0.001). In addition, in RE group, ALR is correlated with waist/hip and waist/height ratios, resistin level, homoeostasis mode assessment (HOMA-IR) index and Lipox(max). CONCLUSION: In obese adolescents boys, moderate exercise training completed at Lipox(max) and combined with energy restriction improves their ability to oxidize lipids, which is associated with a normalization of their adiponectin, leptin and resistin levels resulting in an improved insulin sensitivity, as attested by a higher ALR and a lower HOMA-IR. SN - 1651-2227 UR - https://www.unboundmedicine.com/medline/citation/19489770/Effect_of_individualized_weight_loss_programmes_on_adiponectin_leptin_and_resistin_levels_in_obese_adolescent_boys_ DB - PRIME DP - Unbound Medicine ER -