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Persistently normal alanine aminotransferase levels in HIV/HCV-coinfected patients: the role of steatosis.
HIV Med. 2009 Aug; 10(7):417-21.HM

Abstract

OBJECTIVE

The frequency and significance of, and liver biopsy findings associated with, a persistently normal alanine aminotransferase (ALT) level in HIV/hepatitis C virus (HCV)-coinfected patients are poorly characterized. We analysed factors associated with persistently normal ALT levels, defined as at least three consecutive normal ALT values over a 6-month period, in a group of 381 HIV/HCV-coinfected patients.

METHODS

Patients were categorized into two groups according to ALT values: group 1, patients with persistently normal ALT levels; and group 2, patients with elevated ALT values. Possible interactions with host factors, HIV and HCV viral factors, antiretroviral treatment and histological features were examined.

RESULTS

Thirty-six patients (9.4%) had persistently normal ALT levels. None of the 36 patients had cirrhosis. Seven patients (19.4%) had a METAVIR fibrosis score of F3. In multivariate analysis, a lower mean METAVIR inflammation score [odds ratio (OR) 0.50, 95% confidence interval (CI) 0.28-0.89; P=0.017], the absence of steatosis (OR 0.43, 95% CI 0.20-0.90; P=0.026) and HCV genotype 4 infection (OR 2.81, 95% CI 1.15-6.68; P=0.023) were associated with persistently normal ALT levels.

CONCLUSION

The slower progression of chronic hepatitis in patients with persistently normal ALT levels could be related, in part, to a lower frequency of steatosis.

Authors+Show Affiliations

Groupe Hospitalier Universitaire Est, INSERM U 707, Université Pierre et Marie Curie, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19490173

Citation

Bani-Sadr, F, et al. "Persistently Normal Alanine Aminotransferase Levels in HIV/HCV-coinfected Patients: the Role of Steatosis." HIV Medicine, vol. 10, no. 7, 2009, pp. 417-21.
Bani-Sadr F, Barange K, Daoud F, et al. Persistently normal alanine aminotransferase levels in HIV/HCV-coinfected patients: the role of steatosis. HIV Med. 2009;10(7):417-21.
Bani-Sadr, F., Barange, K., Daoud, F., Jacomet, C., Bicart-See, A., Rosenthal, E., Cacoub, P., Pol, S., Perronne, C., & Carrat, F. (2009). Persistently normal alanine aminotransferase levels in HIV/HCV-coinfected patients: the role of steatosis. HIV Medicine, 10(7), 417-21. https://doi.org/10.1111/j.1468-1293.2009.00702.x
Bani-Sadr F, et al. Persistently Normal Alanine Aminotransferase Levels in HIV/HCV-coinfected Patients: the Role of Steatosis. HIV Med. 2009;10(7):417-21. PubMed PMID: 19490173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Persistently normal alanine aminotransferase levels in HIV/HCV-coinfected patients: the role of steatosis. AU - Bani-Sadr,F, AU - Barange,K, AU - Daoud,F, AU - Jacomet,C, AU - Bicart-See,A, AU - Rosenthal,E, AU - Cacoub,P, AU - Pol,S, AU - Perronne,C, AU - Carrat,F, AU - ,, Y1 - 2009/03/26/ PY - 2009/6/4/entrez PY - 2009/6/6/pubmed PY - 2010/7/21/medline SP - 417 EP - 21 JF - HIV medicine JO - HIV Med VL - 10 IS - 7 N2 - OBJECTIVE: The frequency and significance of, and liver biopsy findings associated with, a persistently normal alanine aminotransferase (ALT) level in HIV/hepatitis C virus (HCV)-coinfected patients are poorly characterized. We analysed factors associated with persistently normal ALT levels, defined as at least three consecutive normal ALT values over a 6-month period, in a group of 381 HIV/HCV-coinfected patients. METHODS: Patients were categorized into two groups according to ALT values: group 1, patients with persistently normal ALT levels; and group 2, patients with elevated ALT values. Possible interactions with host factors, HIV and HCV viral factors, antiretroviral treatment and histological features were examined. RESULTS: Thirty-six patients (9.4%) had persistently normal ALT levels. None of the 36 patients had cirrhosis. Seven patients (19.4%) had a METAVIR fibrosis score of F3. In multivariate analysis, a lower mean METAVIR inflammation score [odds ratio (OR) 0.50, 95% confidence interval (CI) 0.28-0.89; P=0.017], the absence of steatosis (OR 0.43, 95% CI 0.20-0.90; P=0.026) and HCV genotype 4 infection (OR 2.81, 95% CI 1.15-6.68; P=0.023) were associated with persistently normal ALT levels. CONCLUSION: The slower progression of chronic hepatitis in patients with persistently normal ALT levels could be related, in part, to a lower frequency of steatosis. SN - 1468-1293 UR - https://www.unboundmedicine.com/medline/citation/19490173/Persistently_normal_alanine_aminotransferase_levels_in_HIV/HCV_coinfected_patients:_the_role_of_steatosis_ L2 - https://doi.org/10.1111/j.1468-1293.2009.00702.x DB - PRIME DP - Unbound Medicine ER -