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The influence of transmission season on parasitological cure rates and intensity of infection after praziquantel treatment of Schistosoma haematobium-infected schoolchildren in Mozambique.
Parasitology. 2009 Nov; 136(13):1771-9.P

Abstract

Schistosoma haematobium is refractory to praziquantel (PZQ) during the prepatent period of infection. A hypothesis based on this observation is that in areas where S. haematobium transmission is seasonal, the outcome of chemotherapy depends on the timing of the treatment relative to the annual transmission pattern. To examine this hypothesis, a study was carried out in southern Mozambique. Following demonstration of seasonal transmission, PZQ was administered separately to two cohorts of S. haematobium-infected schoolchildren in (1) the high and (2) the low transmission seasons and followed up after two months when levels of infection and intensities were measured. The prevalence of infection decreased from 54.2% and 51.7% in cohorts 1 and 2 to 30.3% and 1.8%, respectively. The geometric mean intensity of infection decreased from 23.3 eggs/10 ml of urine at baseline to 15.6 eggs/10 ml of urine in cohort 1 (treated during high transmission season), and from 23.5 eggs/10 ml urine to 7.3 eggs/10 ml of urine in cohort 2 (treated during low transmission season). The observed cure rates in cohorts 1 and 2 were 69.7% and 98.2%, respectively. Differences in infection between the cohorts in terms of cure rate and level of infection two months post-treatment were statistically significant and indicate that in areas with a seasonal transmission pattern, the effect of PZQ can be enhanced if treatment takes place during the low transmission season. We conclude that appropriately timed PZQ administration will increase the impact of schistosomiasis control programmes.

Authors+Show Affiliations

Instituto Nacional de Saúde - Ministério da Saúde, Av. Eduardo Mondlane No. 1008 Caixa Postal 264, Maputo, Moçambique. geritoaugusto@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19490727

Citation

Augusto, G, et al. "The Influence of Transmission Season On Parasitological Cure Rates and Intensity of Infection After Praziquantel Treatment of Schistosoma Haematobium-infected Schoolchildren in Mozambique." Parasitology, vol. 136, no. 13, 2009, pp. 1771-9.
Augusto G, Magnussen P, Kristensen TK, et al. The influence of transmission season on parasitological cure rates and intensity of infection after praziquantel treatment of Schistosoma haematobium-infected schoolchildren in Mozambique. Parasitology. 2009;136(13):1771-9.
Augusto, G., Magnussen, P., Kristensen, T. K., Appleton, C. C., & Vennervald, B. J. (2009). The influence of transmission season on parasitological cure rates and intensity of infection after praziquantel treatment of Schistosoma haematobium-infected schoolchildren in Mozambique. Parasitology, 136(13), 1771-9. https://doi.org/10.1017/S0031182009006210
Augusto G, et al. The Influence of Transmission Season On Parasitological Cure Rates and Intensity of Infection After Praziquantel Treatment of Schistosoma Haematobium-infected Schoolchildren in Mozambique. Parasitology. 2009;136(13):1771-9. PubMed PMID: 19490727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of transmission season on parasitological cure rates and intensity of infection after praziquantel treatment of Schistosoma haematobium-infected schoolchildren in Mozambique. AU - Augusto,G, AU - Magnussen,P, AU - Kristensen,T K, AU - Appleton,C C, AU - Vennervald,B J, Y1 - 2009/06/02/ PY - 2009/6/4/entrez PY - 2009/6/6/pubmed PY - 2010/2/6/medline SP - 1771 EP - 9 JF - Parasitology JO - Parasitology VL - 136 IS - 13 N2 - Schistosoma haematobium is refractory to praziquantel (PZQ) during the prepatent period of infection. A hypothesis based on this observation is that in areas where S. haematobium transmission is seasonal, the outcome of chemotherapy depends on the timing of the treatment relative to the annual transmission pattern. To examine this hypothesis, a study was carried out in southern Mozambique. Following demonstration of seasonal transmission, PZQ was administered separately to two cohorts of S. haematobium-infected schoolchildren in (1) the high and (2) the low transmission seasons and followed up after two months when levels of infection and intensities were measured. The prevalence of infection decreased from 54.2% and 51.7% in cohorts 1 and 2 to 30.3% and 1.8%, respectively. The geometric mean intensity of infection decreased from 23.3 eggs/10 ml of urine at baseline to 15.6 eggs/10 ml of urine in cohort 1 (treated during high transmission season), and from 23.5 eggs/10 ml urine to 7.3 eggs/10 ml of urine in cohort 2 (treated during low transmission season). The observed cure rates in cohorts 1 and 2 were 69.7% and 98.2%, respectively. Differences in infection between the cohorts in terms of cure rate and level of infection two months post-treatment were statistically significant and indicate that in areas with a seasonal transmission pattern, the effect of PZQ can be enhanced if treatment takes place during the low transmission season. We conclude that appropriately timed PZQ administration will increase the impact of schistosomiasis control programmes. SN - 1469-8161 UR - https://www.unboundmedicine.com/medline/citation/19490727/The_influence_of_transmission_season_on_parasitological_cure_rates_and_intensity_of_infection_after_praziquantel_treatment_of_Schistosoma_haematobium_infected_schoolchildren_in_Mozambique_ L2 - https://www.cambridge.org/core/product/identifier/S0031182009006210/type/journal_article DB - PRIME DP - Unbound Medicine ER -