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Protective efficacy of heat-inactivated B. thailandensis, B. mallei or B. pseudomallei against experimental melioidosis and glanders.
Vaccine. 2009 Jul 16; 27(33):4447-51.V

Abstract

Burkholderia pseudomallei and Burkholderia mallei are gram-negative bacilli that are the causative agents of melioidosis and glanders, respectively. Both humans and animals are susceptible to both diseases. There is currently no vaccine available for the prevention of disease. We report the protective efficacy of heat-inactivated Burkholderia thailandensis, B. mallei or B. pseudomallei cells as vaccines against murine melioidosis and glanders. Immunisation with heat-inactivated B. pseudomallei cells provided the highest levels of protection against either melioidosis or glanders. These studies indicate the longer term potential for heat-inactivated bacteria to be developed as vaccines against melioidosis and glanders.

Authors+Show Affiliations

Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, SP4 OJQ, UK. mstyson@dstl.gov.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19490962

Citation

Sarkar-Tyson, Mitali, et al. "Protective Efficacy of Heat-inactivated B. Thailandensis, B. Mallei or B. Pseudomallei Against Experimental Melioidosis and Glanders." Vaccine, vol. 27, no. 33, 2009, pp. 4447-51.
Sarkar-Tyson M, Smither SJ, Harding SV, et al. Protective efficacy of heat-inactivated B. thailandensis, B. mallei or B. pseudomallei against experimental melioidosis and glanders. Vaccine. 2009;27(33):4447-51.
Sarkar-Tyson, M., Smither, S. J., Harding, S. V., Atkins, T. P., & Titball, R. W. (2009). Protective efficacy of heat-inactivated B. thailandensis, B. mallei or B. pseudomallei against experimental melioidosis and glanders. Vaccine, 27(33), 4447-51. https://doi.org/10.1016/j.vaccine.2009.05.040
Sarkar-Tyson M, et al. Protective Efficacy of Heat-inactivated B. Thailandensis, B. Mallei or B. Pseudomallei Against Experimental Melioidosis and Glanders. Vaccine. 2009 Jul 16;27(33):4447-51. PubMed PMID: 19490962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective efficacy of heat-inactivated B. thailandensis, B. mallei or B. pseudomallei against experimental melioidosis and glanders. AU - Sarkar-Tyson,Mitali, AU - Smither,Sophie J, AU - Harding,S V, AU - Atkins,Timothy P, AU - Titball,Richard W, Y1 - 2009/05/31/ PY - 2009/01/21/received PY - 2009/05/05/revised PY - 2009/05/11/accepted PY - 2009/6/4/entrez PY - 2009/6/6/pubmed PY - 2009/8/14/medline SP - 4447 EP - 51 JF - Vaccine JO - Vaccine VL - 27 IS - 33 N2 - Burkholderia pseudomallei and Burkholderia mallei are gram-negative bacilli that are the causative agents of melioidosis and glanders, respectively. Both humans and animals are susceptible to both diseases. There is currently no vaccine available for the prevention of disease. We report the protective efficacy of heat-inactivated Burkholderia thailandensis, B. mallei or B. pseudomallei cells as vaccines against murine melioidosis and glanders. Immunisation with heat-inactivated B. pseudomallei cells provided the highest levels of protection against either melioidosis or glanders. These studies indicate the longer term potential for heat-inactivated bacteria to be developed as vaccines against melioidosis and glanders. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/19490962/Protective_efficacy_of_heat_inactivated_B__thailandensis_B__mallei_or_B__pseudomallei_against_experimental_melioidosis_and_glanders_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(09)00744-0 DB - PRIME DP - Unbound Medicine ER -