TY - JOUR T1 - Inhibitory effects of quercetin 3-rhamnoside on influenza A virus replication. AU - Choi,Hwa Jung, AU - Song,Jae Hyoung, AU - Park,Kwi Sung, AU - Kwon,Dur Han, Y1 - 2009/03/14/ PY - 2009/01/16/received PY - 2009/03/02/accepted PY - 2009/6/4/entrez PY - 2009/6/6/pubmed PY - 2009/8/25/medline SP - 329 EP - 33 JF - European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences JO - Eur J Pharm Sci VL - 37 IS - 3-4 N2 - Influenza viruses cause significant morbidity and mortality in humans through epidemics or pandemics. The lack of effective therapeutical treatment underlines the importance of research for new antiviral compounds. Flavonoids widely exist in the plant kingdom, and their antiviral activities against various viruses have been recently reported. In this study, the anti-influenza A/WS/33 virus of quercetin 3-rhamnoside (Q3R) from Houttuynia cordata was evaluated using a cytopathic effect (CPE) reduction method, the assay results demonstrated that Q3R possessed strong anti-influenza A/WS/33 virus reducing the formation of a visible CPE. Q3R also did inhibit virus replication in the initial stage of virus infection by indirect interaction with virus particles. However, oseltamivir has relative weaker efficacy compared to Q3R. Therefore, these findings provide important information for the utilization of Q3R for influenza treatment. SN - 1879-0720 UR - https://www.unboundmedicine.com/medline/citation/19491023/Inhibitory_effects_of_quercetin_3_rhamnoside_on_influenza_A_virus_replication_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0928-0987(09)00076-1 DB - PRIME DP - Unbound Medicine ER -