Tags

Type your tag names separated by a space and hit enter

Cancer incidence among patients with alcohol use disorders--long-term follow-up.
Alcohol Alcohol. 2009 Jul-Aug; 44(4):387-91.AA

Abstract

AIMS

The aim of this study was to compare the cancer morbidity in a large cohort of patients with alcohol use disorders in the general Danish population.

METHODS

We included 15,258 men and 3552 women free of cancer when attending the Copenhagen Outpatient Clinic for Alcoholics in the period from 1954 to 1992. The cancer incidence until 1999 of the patients and the general Danish population was obtained through linkage with the Danish Cancer Registry. The incidence rates were standardized (SIR) according to sex, age and calendar time.

RESULTS

A total of 2145 men developed cancer compared to 1140.8 expected cases (SIR = 1.9; 95% confidence interval (CI) 1.8-2.0), while 601 women developed cancer compared to 239.1 expected cases (SIR = 2.5; 95% CI 2.3-2.7). Highly significant and strongly elevated incidence rates were found for cancer of the tongue, mouth, pharynx, oesophagus, liver, larynx and lung. A higher incidence rate was seen for renal cancer for both men (1.4; 1.1-1.8) and women (2.1; 1.0-3.8). The incidence of breast cancer in women was non-significantly elevated, but significantly elevated incidence rate was found for cervical cancer (1.8; 1.2-2.6). We did not observe increased incidence of colon, rectal or urinary bladder cancer.

CONCLUSIONS

In conclusion, this study confirms the well-established association between high alcohol intake and cancer of the upper digestive tract and liver. In addition, the results indicate a significantly elevated occurrence of renal cancer, but not of breast cancer and colorectal cancer, in patients with alcohol use disorders.

Authors+Show Affiliations

National Institute of Public Health, University of Southern Denmark, Øster Farimagsgade 5, DK-1399 Copenhagen. lct@niph.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19491282

Citation

Thygesen, Lau Caspar, et al. "Cancer Incidence Among Patients With Alcohol Use Disorders--long-term Follow-up." Alcohol and Alcoholism (Oxford, Oxfordshire), vol. 44, no. 4, 2009, pp. 387-91.
Thygesen LC, Mikkelsen P, Andersen TV, et al. Cancer incidence among patients with alcohol use disorders--long-term follow-up. Alcohol Alcohol. 2009;44(4):387-91.
Thygesen, L. C., Mikkelsen, P., Andersen, T. V., Tønnesen, H., Juel, K., Becker, U., & Grønbaek, M. (2009). Cancer incidence among patients with alcohol use disorders--long-term follow-up. Alcohol and Alcoholism (Oxford, Oxfordshire), 44(4), 387-91. https://doi.org/10.1093/alcalc/agp034
Thygesen LC, et al. Cancer Incidence Among Patients With Alcohol Use Disorders--long-term Follow-up. Alcohol Alcohol. 2009 Jul-Aug;44(4):387-91. PubMed PMID: 19491282.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cancer incidence among patients with alcohol use disorders--long-term follow-up. AU - Thygesen,Lau Caspar, AU - Mikkelsen,Pernille, AU - Andersen,Tina Veje, AU - Tønnesen,Hanne, AU - Juel,Knud, AU - Becker,Ulrik, AU - Grønbaek,Morten, Y1 - 2009/06/02/ PY - 2009/6/4/entrez PY - 2009/6/6/pubmed PY - 2009/9/3/medline SP - 387 EP - 91 JF - Alcohol and alcoholism (Oxford, Oxfordshire) JO - Alcohol Alcohol VL - 44 IS - 4 N2 - AIMS: The aim of this study was to compare the cancer morbidity in a large cohort of patients with alcohol use disorders in the general Danish population. METHODS: We included 15,258 men and 3552 women free of cancer when attending the Copenhagen Outpatient Clinic for Alcoholics in the period from 1954 to 1992. The cancer incidence until 1999 of the patients and the general Danish population was obtained through linkage with the Danish Cancer Registry. The incidence rates were standardized (SIR) according to sex, age and calendar time. RESULTS: A total of 2145 men developed cancer compared to 1140.8 expected cases (SIR = 1.9; 95% confidence interval (CI) 1.8-2.0), while 601 women developed cancer compared to 239.1 expected cases (SIR = 2.5; 95% CI 2.3-2.7). Highly significant and strongly elevated incidence rates were found for cancer of the tongue, mouth, pharynx, oesophagus, liver, larynx and lung. A higher incidence rate was seen for renal cancer for both men (1.4; 1.1-1.8) and women (2.1; 1.0-3.8). The incidence of breast cancer in women was non-significantly elevated, but significantly elevated incidence rate was found for cervical cancer (1.8; 1.2-2.6). We did not observe increased incidence of colon, rectal or urinary bladder cancer. CONCLUSIONS: In conclusion, this study confirms the well-established association between high alcohol intake and cancer of the upper digestive tract and liver. In addition, the results indicate a significantly elevated occurrence of renal cancer, but not of breast cancer and colorectal cancer, in patients with alcohol use disorders. SN - 1464-3502 UR - https://www.unboundmedicine.com/medline/citation/19491282/Cancer_incidence_among_patients_with_alcohol_use_disorders__long_term_follow_up_ L2 - https://academic.oup.com/alcalc/article-lookup/doi/10.1093/alcalc/agp034 DB - PRIME DP - Unbound Medicine ER -