Tags

Type your tag names separated by a space and hit enter

Age at onset of anorexia nervosa and breast cancer risk.
Eur J Cancer Prev. 2009 Jun; 18(3):207-11.EJ

Abstract

The objective of this study was to investigate breast cancer occurrence among women treated for anorexia nervosa (AN), with emphasis on age at the onset of this disorder. We conducted a register-based retrospective cohort with a total of 6009 women with at least one admission with an AN diagnosis during the period 1973-2003 in Sweden. During a mean follow-up of 13.4 years, information on 80 057 women-years was generated. The standardized incidence ratio (SIR)--the ratio of observed-to-expected number of cases--was used as the measure of relative risk. Overall, 16 women developed breast cancer versus 25.5 expected cases [SIR: 0.6, 95% confidence interval (CI): 0.4-0.9]. Among women who were first admitted for AN between the age of 10 and 24 years, four developed breast cancer versus 11.3 expected (SIR: 0.4, 95% CI: 0.1-0.9). In this group of women with early onset AN, only one parous woman developed breast cancer versus 6.3 expected (SIR: 0.2, 95% CI: 0-0.9). Among women first hospitalized for AN between the age of 25 and 40 years, 12 developed breast cancer, whereas the expected number was 14.2, a nonsignificant deficit. Our results suggest that early onset AN may play an important role in the development of breast cancer, possibly because of the extreme restriction of energy intake at a crucial period for mammary gland development. Late onset AN is likely to play a relatively less important role.

Authors+Show Affiliations

Department of Neuroscience, Psychiatry, Uppsala University Hospital, Uppsala, Sweden. fotis.papadopoulos@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19491607

Citation

Papadopoulos, Fotios C., et al. "Age at Onset of Anorexia Nervosa and Breast Cancer Risk." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 18, no. 3, 2009, pp. 207-11.
Papadopoulos FC, Pantziaras I, Lagiou P, et al. Age at onset of anorexia nervosa and breast cancer risk. Eur J Cancer Prev. 2009;18(3):207-11.
Papadopoulos, F. C., Pantziaras, I., Lagiou, P., Brandt, L., Ekselius, L., & Ekbom, A. (2009). Age at onset of anorexia nervosa and breast cancer risk. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 18(3), 207-11. https://doi.org/10.1097/CEJ.0b013e32831bc558
Papadopoulos FC, et al. Age at Onset of Anorexia Nervosa and Breast Cancer Risk. Eur J Cancer Prev. 2009;18(3):207-11. PubMed PMID: 19491607.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age at onset of anorexia nervosa and breast cancer risk. AU - Papadopoulos,Fotios C, AU - Pantziaras,Ioannis, AU - Lagiou,Pagona, AU - Brandt,Lena, AU - Ekselius,Lisa, AU - Ekbom,Anders, PY - 2009/6/4/entrez PY - 2009/6/6/pubmed PY - 2009/8/12/medline SP - 207 EP - 11 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur J Cancer Prev VL - 18 IS - 3 N2 - The objective of this study was to investigate breast cancer occurrence among women treated for anorexia nervosa (AN), with emphasis on age at the onset of this disorder. We conducted a register-based retrospective cohort with a total of 6009 women with at least one admission with an AN diagnosis during the period 1973-2003 in Sweden. During a mean follow-up of 13.4 years, information on 80 057 women-years was generated. The standardized incidence ratio (SIR)--the ratio of observed-to-expected number of cases--was used as the measure of relative risk. Overall, 16 women developed breast cancer versus 25.5 expected cases [SIR: 0.6, 95% confidence interval (CI): 0.4-0.9]. Among women who were first admitted for AN between the age of 10 and 24 years, four developed breast cancer versus 11.3 expected (SIR: 0.4, 95% CI: 0.1-0.9). In this group of women with early onset AN, only one parous woman developed breast cancer versus 6.3 expected (SIR: 0.2, 95% CI: 0-0.9). Among women first hospitalized for AN between the age of 25 and 40 years, 12 developed breast cancer, whereas the expected number was 14.2, a nonsignificant deficit. Our results suggest that early onset AN may play an important role in the development of breast cancer, possibly because of the extreme restriction of energy intake at a crucial period for mammary gland development. Late onset AN is likely to play a relatively less important role. SN - 1473-5709 UR - https://www.unboundmedicine.com/medline/citation/19491607/Age_at_onset_of_anorexia_nervosa_and_breast_cancer_risk_ L2 - https://doi.org/10.1097/CEJ.0b013e32831bc558 DB - PRIME DP - Unbound Medicine ER -